scholarly journals From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions

2018 ◽  
Vol 246 (4) ◽  
pp. 395-404 ◽  
Author(s):  
Catherine G Fischer ◽  
Laura D Wood
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Molecular Characterization ◽  
Somatic Mutation ◽  
Precursor Lesions

scholarly journals Technical Insights into Highly Sensitive Isolation and Molecular Characterization of Fixed and Live Circulating Tumor Cells for Early Detection of Tumor Invasion

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169427 ◽  
Author(s):  
Sophie Laget ◽  
Lucile Broncy ◽  
Katia Hormigos ◽  
Dalia M. Dhingra ◽  
Fatima BenMohamed ◽  
...  
Keyword(s):  
Early Detection ◽  
Tumor Cells ◽  
Molecular Characterization ◽  
Circulating Tumor Cells ◽  
Tumor Invasion ◽  
Highly Sensitive

Molecular characterization of early precursor lesions of pancreatic ductal adenocarcinoma

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S4
Author(s):  
Lisa Frohn ◽  
Lena Häberle ◽  
Wolfgang Göring ◽  
Matthias Wirth ◽  
Irene Esposito
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Molecular Characterization ◽  
Ductal Adenocarcinoma ◽  
Precursor Lesions

Molecular Characterization of Advanced Mutants for Early Detection of High β-carotene Concetration in Pepper Breeding Programms

2013 ◽  
Vol 66 (2) ◽  
Author(s):  
Veselin Petrov ◽  
Iliya Denev ◽  
Marian Draganov ◽  
Oleg Timin ◽  
Ivelin Panchev ◽  
...  
Keyword(s):  
Early Detection ◽  
Molecular Characterization ◽  
Β Carotene ◽  
Pepper Breeding

Identification and Molecular Characterization of Mung Bean Yellow Mosaic Virus in French Bean through Coat Protein Gene

2020 ◽  
Author(s):  
T.C. Archith ◽  
V. Devappa ◽  
B. Manjunath ◽  
Chirag Reddy
Keyword(s):  
Coat Protein ◽  
Early Detection ◽  
Mosaic Virus ◽  
Molecular Characterization ◽  
Mung Bean ◽  
French Bean ◽  
Bean Yellow Mosaic Virus ◽  
Yellow Mosaic Virus ◽  
Cp Gene

Background: French bean (Phaseolus vulgaris L.), is one of the important legume vegetables grown in India. The disease mung bean yellow mosaic virus (MYMV) limits successful production of beans. MYMV has become an epidemic in bean growing regions, particularly in the tropical and subtropical countries. In summer, the disease is more serious and widely distributed and reported in various countries. The current study is aimed at identification of MYMV and molecular characterization of mung bean yellow mosaic virus in French bean. This study will be helpful for early detection of the virus, so that better preventive measures can be taken to control MYMV.Methods: The investigations were conducted during 2016-2017, all the agro climatic zones of Karnataka province were surveyed. The coat protein (CP) gene of MYMV was amplified using gene specific primer with DNA isolated from MYMV infected leaves samples in french bean. Polymerase chain reaction products were Sequenced and analysed using a bioinformatic tool. Result: The CP gene decrypt sequences analysis revealed that the identity and similarity in global alignment for all the obtained sequences ranging from 80.8 to 95.3% with reference to MYMV, whereas for horse gram yellow mosaic virus (HYMV) it ranges from 90.4 to 99.1%. Two distinct yellow mosaic viruses infecting french bean (MYMV and HYMV) were identified and it was observed that there exists considerable genetic variation among these species. Present work showed that the CP region is efficient enough to provide a simple, rapid and reliable method for early detection of MYMV infections in french bean, which would help to develop proper management strategies to control these viruses.

scholarly journals Can miRNA Biomarkers Be Utilized to Improve the Evaluation and Management of Pancreatic Cystic Lesions?

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Linda S. Lee ◽  
Anna E. Szafranska-Schwarzbach ◽  
Bernard F. Andruss ◽  
Darwin L. Conwell
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Molecular Characterization ◽  
Clinical Management ◽  
Cystic Lesions ◽  
Molecular Tools ◽  
Cystic Pancreatic Lesions ◽  
Novel Therapeutic

AbstractThis article reviews the current strategies and challenges of diagnosing pancreatic cystic lesions, and presents an overview of molecular tools that are available to enhance diagnostic accuracy. Specifically, we highlight the emergence of microRNAs (miRNAs) as diagnostic markers. miRNA signatures have been reported for both solid tissue and biofluid specimens, including cyst fluid, collected from patients with solid and cystic pancreatic lesions. These miRNA signatures offer the opportunity to improve molecular characterization of pancreatic lesions, to help guide clinical management through early diagnosis and informed prognosis, and to provide novel therapeutic targets for pancreatic cancer.

scholarly journals Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature

Oncotarget ◽  
2016 ◽  
Vol 7 (38) ◽  
pp. 62533-62546 ◽  
Author(s):  
Jaeyun Jung ◽  
Cue Hyunkyu Lee ◽  
Hyang Sook Seol ◽  
Yeon Sook Choi ◽  
Eunji Kim ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patient ◽  
Molecular Characterization ◽  
Pancreatic Cancer Patient
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