Intraductal carcinoma of the prostate in the absence of high‐grade invasive carcinoma represents a molecularly distinct type of
            in situ
            carcinoma enriched with oncogenic driver mutations

Abstract Intraductal carcinoma of the prostate (IDC-P) gland represents an intraluminal neoplastic proliferation that is distinct from high-grade prostatic intraepithelial neoplasia (HG-PIN) and almost always coexists with large-volume, high-stage, and high-grade invasive carcinoma. We document an unusual presentation of apparently “early” IDC-P without an aggressive invasive element that, despite being confined to the acinar-ductal system, has gained access to the ejaculatory duct and seminal vesicle by transmucosal spread. This finding confirms that IDC-P, in contrast to HG-PIN, is inherently aggressive and has the ability to spread beyond the prostate gland. In this case, the absence of an aggressive invasive element suggests that IDC-P has most likely evolved within the lumens directly from HG-PIN.

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Role of Ag NORs in Improve Diagnosis of Breast Cancer with Different grades and Subtypes’ among Sudanese women

Science Progress and Research ◽

10.52152/spr/2021.166 ◽

2021 ◽

Vol 1 (4) ◽

pp. 443-448

Author(s):

Doaa Ibrahim Ahmed

Keyword(s):

Breast Cancer ◽

Invasive Carcinoma ◽

Ductal Carcinoma ◽

Lobular Carcinoma ◽

Age Group ◽

Lobular Carcinoma In Situ ◽

Tissue Sections ◽

In Situ Carcinoma

This study aimed to evaluate the role of Ag NORs in improves diagnosis of Breast cancer with different subtypes’ among Sudanese Patients. This study include tissue sections of breast cancer diagnosed women, they were 30, ductal and lobular invasive carcinoma were 10 for each, while ductal and lobular in-situ carcinoma were 5 each. Found correlation between subtypes of breast cancer and Ag NOR , Invasive ductal carcinoma had more NOR while the lobular carcinoma in situ was less one , Stage III most frequency than the other stage. Silver staining were performed and Ag-NOR were detected in ductal and lobular invasive carcinoma more than ductal and lobular in-situ carcinoma, grade III has more frequency of Ag-NOR than other stages, and no correlation found between Ag-NOR and age group

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The Intraductal Carcinoma of the Breast is Never a Carcinoma «In Situ».

Tumori Journal ◽

10.1177/030089166705300614 ◽

1967 ◽

Vol 53 (6) ◽

pp. 641-644 ◽

Cited By ~ 4

Author(s):

Carlo Sirtori ◽

Franco Talamazzi

Keyword(s):

Lymph Node ◽

Tumor Cells ◽

Lymph Node Metastases ◽

Carcinoma In Situ ◽

Intraductal Carcinoma ◽

Carcinoma Of The Breast ◽

In Situ Carcinoma ◽

Intraductal Cancer ◽

Node Metastases

Histological patterns of « intraductal carcinoma » were observed in lymph node metastases, in 16 of 69 intraductal carcinomas of the breast. The so-called intraductal cancer, generally considered a « in situ » carcinoma of the breast, is therefore an infiltrating tumor; its histological picture, present sometime also in the metastases, is related to a particular morphogenetic differentiative activity of the tumor cells.

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Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Pathology ◽

10.1016/j.pathol.2019.11.001 ◽

2020 ◽

Vol 52 (2) ◽

pp. 192-196 ◽

Cited By ~ 9

Author(s):

Hemamali Samaratunga ◽

Brett Delahunt ◽

Lars Egevad ◽

John R. Srigley ◽

Athanase Billis ◽

...

Keyword(s):

Invasive Carcinoma ◽

Intraductal Carcinoma ◽

Carcinoma Of The Prostate ◽

Aggressive Form

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Microglandular Adenosis: A Possible Non-Obligate Precursor to Breast Carcinoma With Potential to Either Luminal-Type or Basal-Type Differentiation

International Journal of Surgical Pathology ◽

10.1177/1066896919845493 ◽

2019 ◽

Vol 27 (7) ◽

pp. 781-787 ◽

Cited By ~ 1

Author(s):

Alexander T. Damron ◽

Katrina Korhonen ◽

Samantha Zuckerman ◽

Julia Tchou ◽

Kimberly L. Dumoff ◽

...

Keyword(s):

Breast Carcinoma ◽

Invasive Carcinoma ◽

Case Reports ◽

Unique Case ◽

Diagnostic Pitfall ◽

In Situ Carcinoma ◽

Luminal Type ◽

Basal Type ◽

Microglandular Adenosis

Microglandular adenosis (MGA) of the breast is exceedingly rare, with only a few case reports and series published to date. Previous studies have elegantly demonstrated the progression of benign MGA to atypical MGA to MGA-in situ carcinoma to invasive carcinoma and therefore suggest MGA as a possible non-obligate precursor lesion to a subset of breast carcinomas. Immunohistochemically, MGA is negative for estrogen receptor (ER), progesterone receptor (PR), and HER2-neu oncoprotein expression, and carcinomas arising in the setting of MGA are often reported to be triple negative. In this article, we present a unique case of an ER+/PR+/HER2− invasive carcinoma associated with MGA and atypical MGA. Our case highlights the diagnostic pitfall of MGA and suggests that MGA is a heterogeneous group of lesions with potential for either luminal-type or basal-type differentiation during progression to breast carcinoma.

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Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia

Modern Pathology ◽

10.1038/modpathol.2012.201 ◽

2012 ◽

Vol 26 (4) ◽

pp. 587-603 ◽

Cited By ~ 96

Author(s):

Tamara L Lotan ◽

Berrak Gumuskaya ◽

Hameed Rahimi ◽

Jessica L Hicks ◽

Tsuyoshi Iwata ◽

...

Keyword(s):

Intraepithelial Neoplasia ◽

Prostatic Intraepithelial Neoplasia ◽

Intraductal Carcinoma ◽

High Grade ◽

Protein Loss ◽

Pten Protein ◽

Carcinoma Of The Prostate

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Intraductal carcinoma of the prostate does not always represent invasive high‐grade carcinoma extending into ducts

Histopathology ◽

10.1111/his.14273 ◽

2020 ◽

Vol 78 (2) ◽

pp. 345-346

Author(s):

Jonathan I. Epstein

Keyword(s):

Intraductal Carcinoma ◽

High Grade ◽

Carcinoma Of The Prostate ◽

High Grade Carcinoma

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Is Ductal Carcinoma in Situ with “Possible Invasion” More Predictive of Invasive Carcinoma than Pure Ductal Carcinoma in Situ?

Canadian Association of Radiologists Journal ◽

10.1016/j.carj.2010.10.002 ◽

2012 ◽

Vol 63 (2) ◽

pp. 146-152 ◽

Cited By ~ 3

Author(s):

Tal Arazi-Kleinman ◽

Petrina A. Causer ◽

Sharon Nofech-Mozes ◽

Roberta A. Jong

Keyword(s):

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Invasive Carcinoma ◽

Breast Biopsy ◽

Ductal Carcinoma ◽

Clinical Indication ◽

Low Grade ◽

High Grade ◽

Sample Number

Objectives To compare the underestimation of ductal carcinoma in situ (DCIS) vs DCIS with “possible invasion” at breast biopsy and to determine if any factors related to clinical indication, imaging abnormality, biopsy, or DCIS-grade affected the likelihood of underestimation. Methods Of 3836 consecutive lesions that were biopsied by using a 14-gauge needle, 117 lesions revealed DCIS. Surgical pathology results of invasive carcinoma were compared with needle biopsy results of DCIS or DCIS with possible invasion. Clinical indication, imaging abnormality, biopsy guidance modality, sample number, and histologic grade were recorded. Yates corrected χ2 and Fisher exact tests were used to determine differences between groups. Results A total of 101 lesions were DCIS and 16 were DCIS with possible invasion at biopsy. Thirty-six of 117 lesions (31%) revealed invasive carcinoma at resection pathology. Invasive carcinoma was present more often when DCIS with possible invasion was diagnosed compared with pure DCIS (7/16 [44%] vs 29/101 [29%], P = .36). No factor, including clinical indication, imaging abnormality, biopsy guidance method, sample number, or grade, was found to significantly affect the likelihood of underestimation for lesions diagnosed as DCIS vs DCIS with “possible invasion.” The likelihood of pure DCIS underestimation significantly increased when lesions were high grade compared with either intermediate or low grade (18/44 [41%] vs 9/44 [21%] vs 2/10 [20%], P = .03). Conclusion For lesions biopsied by using a 14-gauge needle, there is a trend towards underestimation of the presence of invasive carcinoma when pathology reveals DCIS with possible invasion compared with pure DCIS. High-grade DCIS was significantly more likely to be underestimated.

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