Role of Ag NORs in Improve Diagnosis of Breast Cancer with Different grades and Subtypes’ among Sudanese women

This study aimed to evaluate the role of Ag NORs in improves diagnosis of Breast cancer with different subtypes’ among Sudanese Patients. This study include tissue sections of breast cancer diagnosed women, they were 30, ductal and lobular invasive carcinoma were 10 for each, while ductal and lobular in-situ carcinoma were 5 each. Found correlation between subtypes of breast cancer and Ag NOR , Invasive ductal carcinoma had more NOR while the lobular carcinoma in situ was less one , Stage III most frequency than the other stage. Silver staining were performed and Ag-NOR were detected in ductal and lobular invasive carcinoma more than ductal and lobular in-situ carcinoma, grade III has more frequency of Ag-NOR than other stages, and no correlation found between Ag-NOR and age group

Bioinformatics as Emerging Tool and Pipeline Frameworks

In this article, we will discuss the areas of origin of bioinformatics in the human health care system. Due to the growing network of biological information databases such as human genomes, transcriptomics and proteomics, bioinformatics has become the approach of choosing forensic sciences. High-throughput bioinformatic analyses increasingly rely on pipeline frameworks to process sequence and metadata. Here we survey and compare the design philosophies of several current pipeline frameworks.

Phytochemical and Pharmacological Properties of Catharanthus roseus (Vinca)

Vinca alkaloids obtained from Madagascar are a subset of drugs. Generally, they are naturally extracted from the Vinca rosea plant, Catharanthus roseus G, Don and show hyperglycemia activity as well as cytotoxic effects. It is used to treat various diseases such as diabetes, hypertension, cancer, asthma, inflammation, malaria, angiogenesis, brain imbalance, dysentery, and is also used as a disinfectant that occurs due to potent microorganisms. The vinca alkaloids are played an essential role to fight cancer disease. There are some major vinca alkaloids in clinical use: Vinblastin, Vincristine, Vindesine, tabersonine, vinorelbine, and Vinpocetine, etc. The flowers juice of Vinca rosea is utilized to treat several skin problems e.g. acne, eczema, and dermatitis. According to our opinion that it may be help scientists, ayurvedic practitioners, pharmacognosists, botanists, researchers, and students who are active in the field of medicinal plants research.

Application of Artificial Intelligence in Magnetic Resonance Imaging to reduce Gadolinium accumulation in patients with multiple sclerosis: A Review

Gadolinium (Gd) is a based contrast agent is used for Magnetic Resonance Imaging (MRI). In India, gadobutrolhas been is approved for MRI of the Central Nervous System (CNS), liver, kidneys, and breast. It has been noted in several studies that the accumulation of gadolinium occurs in different structures in the brain. Patients with Multiple Sclerosis (MS) are regularly followed up with MRI scans and MRI with contrast enhancement is the most common method of distinguishing new-onset pathological changes. Developments in technology and methods in artificial intelligence have shown that there is reason to map out the X-ray technician’s work with examinations and medicines administered to patients may be altered to prevent the accumulation of gadolinium.

Conservation of Mahseer Fish in Madhya Pradesh by following M.I.R.A.C.L.E strategy

The endangered Mahseer species, especially Tor tor (Ham) is a state fish of Madhya Pradesh province of India. Ongoing construction of dams on the state’s rivers destroys the breeding and habitat ground of this fish species. To inspect the current situation, the conservation of Mahseer is commencing a big challenge for biodiversity developers. To conserve the fish from steady deterioration, a unique M.I.R.A.C.L.E strategy has been endorsed which includes mapping of habitat, involving people with this project, research and data collection, advocacy for policy and legal framework, conservation measures following the restoration of the wild species through ex-situ & in-situ conservation, livelihoods connections, extension and training of frontline foresters on this conservation issue. In the future, this M.I.R.A.C.L.E strategy could help to guide in the right way to protecting this valuable fish species from being extinct.

Non- Carious Cervical Lesions: A Review

Non-carious cervical lesions (NCCL) are characterized by a loss of hard dental tissue near the cement-enamel-junction. Commonly, their shape is like a wedge with the apex pointing inwards. Other times, they appear as regular depressions, like a dome or a cup. Their etiology seems to be related to different factors: hexogen and endogen acids, mechanical abrasive action, tooth flexion under axial and non-axial loads. Moreover, it seems that a fundamental role is ascribable to tooth bending phenomena due to the strength components parallel or oblique to the occlusal level, which occur during the normal function as well as during Para functions. The frequent therapeutic failures are probably due to the same factors causing the onset of the original lesion. Several materials have been proposed to restore NCCL: amalgam (abandoned) glass-ionomer cements, composers, and composite resins. Early failures of these restorations have often been reported in the literature, probably due to the same factors which originally caused the lesions. Further investigations are required to determine more reliable restorative therapies.

Uremic Stomatitis: A Case Report

Uremic stomatitis is a rarely reported oral mucosal disorder associated with renal disorder. It is mostly seen in cases of end stage renal disease or undiagnosed or untreated chronic renal failure. Its frequency has diminished due to the advent of renal dialysis. Clinically uremic stomatitis is characterised by the presence of painful plaques and crusts that are usually distributed on the buccal and labial mucosa, dorsal or ventral surface of the tongue, gingiva and the floor of the mouth. Ultimate treatment consists of improvement of blood urea concentration and underlying renal failure is supported by enhancement of oral hygiene with antiseptic mouthwashes and antimicrobial/ antifungal agents, if necessary. Here we report a case of a 50 year old Male patient who reported to the department with the complaint of inability to open mouth due to ulcers present intra-orally, who was a kidney patient undergoing dialysis, who was then treated with topical steroid and antifungal medications with follow up made once in a week.

Assessment of Hazard Index and Incremental Life Cancer Risk Associated with Heavy Metals in the Soils

The purpose of this review was to evaluate the hazard Index and Incremental life cancer risks associated with heavy metal contaminations of the soil for residents in the country. Many scientific articles have been accessible online in the Nigeria were evaluated for the estimation of [Hazard Index and Incremental Life Cancer Risk] for individual heavy metals. The heavy metals considered in this work are; [Lead (Pb), Copper (Cu), Iron (Fe), Manganese (Mn), Zinc (Zn), Chromium (Cr), and Cadmium (Cd)] The concentrations of these metals were obtained from the literature and modeled for, hazard index (HI), and carcinogenic risk (ILCR) via ingestion, inhalation, and dermal pathways for adults following the United State Environmental Protection Agency [USEPA] method. The hazard index for all the exposure pathways (ingestion, inhalation, and dermal contact) was found to be 21914, 1020.7, 580.8, 2.641, 0.272, 0.05165, 0.021, and 0.011[mg/kg/day], for Fe, Mn, Cr, Pb, Cu, Zn, Ni, and Cd respectively. United States EPA considered an overall hazard index value of 1.0 as an acceptable threshold below which no observable clinical effect was reported. In order of magnitude: Fe > Mn > Cr > Pb > Cu > Zn > Ni > Cd, Fe, Mn, and Cr have the highest Hazard Index in all the soil samples analyzed by different researchers in the country. In all the heavy metals reviewed, the Cd has the highest Incremental Life Cancer Risk followed by Cr, Pb, and Ni. This indicated that most of the areas are highly polluted with Cd, Cr, and Pb. Therefore, dwellers of the locations may likely be affected with cancer due to the ingestion, inhalation, and dermal contact with metals. The Overall results suggested that there is probable adverse health effects to an exposed population in all locations reviewed. Therefore, an effort will be made to prevent the transfer of heavy metals in the soil to the surrounding environment should be encouraged and soil remediation to further reduce the concentration of heavy metals needs to be effected immediately at root level.

Acute Pancreatitis Following Organophosphate Compound Poisoning: A Case Report

Organophosphate compounds are chemicals containing central phosphate molecules with alkyl or aromatic substituent’s. They occur in diverse forms and are used as pesticides, herbicides, nerve agents, etc. Organophosphate compounds are frequently used as pesticides in agrarian communities all across the world. South Asian countries such as Nepal use vast quantities of Organophosphate compounds for pest control in agriculture. Therefore, accidental and suicidal ingestion of Organophosphate compound poisoning has been common especially among the agricultural rural communities. Apart from muscarinic, nicotinic and central nervous system effects in rare instances, Organophosphate compounds are known to cause pancreatitis.

Chemical Analysis of Ground water in Hinganghat, District Wardha (Ms), India

Ground water is one of the most useful water sources found in earth. The importance of the chemical analysis underlies the fact that the chemistry of ground water can directly be rated with the source of water, climate and geology of the region. Contamination of such water is responsible for creating health hazards. In this paper chemical analysis of the ground water has been carried out for Hinganghat in Wardha district. The water sample collected from different location in Hinganghat, Wardha (India). The ground water samples were analyzed for the following chemical parameters; pH, Electrical Conductivity (EC), Total Alkalinity (TA), Total Hardness (TH), Chloride, Nitrate, Sulphate, Dissolved Oxygen (DO) and Total Dissolved Solid (TDS). The results Obtained shown that it is free from anomalies and suitable for human and cattle consumption as well as irrigation purpose in Hinganghat, Wardha districts, Maharashtra, India.