Cerebral sinus venous thrombosis during childhood acute lymphoblastic leukemia therapy: Risk factors and management

2017 ◽  
Vol 64 (12) ◽  
pp. e26694 ◽  
Author(s):  
Khaled M. Ghanem ◽  
Raghida M. Dhayni ◽  
Carol Al-Aridi ◽  
Nidale Tarek ◽  
Hani Tamim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lymphoblastic Leukemia ◽  
Venous Thrombosis ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis

scholarly journals Anticoagulation treatment and prophylactic edoxaban for cerebral sinus venous thrombosis in an adolescent with acute lymphoblastic leukemia

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110132
Author(s):  
Masaya Koganesawa ◽  
Ryosuke Matsuno ◽  
Yumiko Sugishita ◽  
Ryota Kaneko ◽  
Naoko Kawabata ◽  
...  
Keyword(s):  
Young Adults ◽  
Acute Lymphoblastic Leukemia ◽  
Venous Thrombosis ◽  
Induction Therapy ◽  
Lymphoblastic Leukemia ◽  
Adolescents And Young Adults ◽  
Increased Risk ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis

Pediatric acute lymphoblastic leukemia regimens include large L-asparaginase dosages and steroids, which are associated with an increased risk of venous thromboemboli in adolescents and young adults. Herein, we report the case of an 18-year-old male with acute lymphoblastic leukemia, who was treated with the pediatric regimen, in which edoxaban was employed as a prophylaxis against cerebral sinus venous thrombosis. The event happened on day 20 of induction therapy, when brain magnetic resonance imaging demonstrated a cerebral sinus venous thrombosis in the superior sagittal sinus. Anticoagulation therapy was initiated, and the patient’s symptoms disappeared 3 days later. The induction therapy was restarted after an interruption of 16 days, and the consolidation therapies, which included L-asparaginase and steroids, were completed. Edoxaban was administered as a prophylaxis during the consolidation therapy. There were no further adverse events. Edoxaban could be an effective prophylaxis for coagulation complications in adolescents and young adults with acute lymphoblastic leukemia.

scholarly journals Treatment Induced Cerebral Sinus Venous Thrombosis in Childhood Acute Lymphoblastic Leukemia: New Risk Factors to Consider

2021 ◽  
Author(s):  
Habib El-Khoury ◽  
Omran Saifi ◽  
Mohamad Chahrour ◽  
Salame Haddad ◽  
Khaled Ghanem ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Lymphoblastic Leukemia ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Mediastinal Mass ◽  
Lymphoblastic Leukemia ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis

Background: Cerebral Sinus Venous Thrombosis (CSVT) is one of many side effects encountered during acute lymphoblastic leukemia (ALL) therapy. Due to the rarity of cases, lack of data, consensus management, no recommendations exist to target the population at risk. Methods: This is a retrospective chart review of 229 consecutive patients diagnosed with ALL and aged 1–21 years, treated at the Children’s Cancer Institute (CCI) between October 2007 and February 2017. Results: The incidence of CSVT was 10.5%. Using univariate analysis, increased risk of CSVT was observed with male gender, age >10 years, T-cell immunophenotype, intermediate/high risk disease, maximum Triglyceride (TG) level of > 615 mg/dL, presence of mediastinal mass, and larger body surface area. With multivariate analysis, the only statistically significant risk factors were maximum TG level, body surface area (BSA), presence of mediastinal mass, and risk stratification (intermediate/high risk). Conclusion: Our study was able to unveil TG level of > 615 mg/dL, mediastinal mass, and a larger body surface area as novel risk factors that have not been previously discussed in the literature.

Cerebral Sinus Venous Thrombosis and Prothrombotic Risk Factors in Children

2018 ◽  
Vol 40 (6) ◽  
pp. e369-e372 ◽  
Author(s):  
Alper Ozcan ◽  
Mehmet Canpolat ◽  
Selim Doganay ◽  
Ekrem Unal ◽  
Musa Karakukcu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Cerebral Sinus Venous Thrombosis ◽  
Prothrombotic Risk Factors ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis

Treatment‐induced cerebral sinus venous thrombosis in childhood acute lymphoblastic malignancies: New risk factors to consider

2021 ◽  
Author(s):  
Habib El‐Khoury ◽  
Omran Saifi ◽  
Salame Haddad ◽  
Mohamad Chahrour ◽  
Khaled M. Ghanem ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis

Risk factors, clinical profile, and long-term outcome of 428 patients of cerebral sinus venous thrombosis: Insights from Nizam′s Institute Venous Stroke Registry, Hyderabad (India)

2012 ◽  
Vol 60 (2) ◽  
pp. 154 ◽  
Author(s):  
Subhash Kaul ◽  
AK Meena ◽  
KRukmini Mridula ◽  
Deekshanti Narayan ◽  
K Ravishankar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Stroke Registry ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis ◽  
Venous Stroke

scholarly journals Cerebral sinus venous thrombosis

2016 ◽  
Vol 5 (1) ◽  
pp. 177
Author(s):  
Sandhya Manorenj ◽  
Sudhaker Barla
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Venous Thrombosis ◽  
Protein S ◽  
Brain Parenchyma ◽  
Protein S Deficiency ◽  
S Deficiency ◽  
Cerebral Sinus Venous Thrombosis ◽  
Cerebral Sinus ◽  
Sinus Venous Thrombosis

Background: Intracranial Sino venous occlusive disease is an infrequent condition and accounts only 0.5-1% of all strokes. Objective of the study was to know the prevalence, pattern and risk factors involved in patients of cerebral sinus venous thrombosis (CSVT).Methods: Hospital databases were searched retrospectively and patients diagnosed with CSVT from December 2014 to February 2016 were identified. Data on clinical presentation, risk factor, cerebral sinus involved, hospital stay and outcome were analyzed.Results: Fifteen patients (3.4%) were identified as CSVT out of a total acute stroke case of 430. Mean age of patients was 31 years and 11 (73.3%) were males. The presenting symptoms included headache (n=14), altered sensorium (n=1) and seizures (n=5); signs included hemi paresis (n=4), papilledema (n=8) and bilateral VI nerve palsy (n=3). Majority had aseptic CSVT (n=14), and one patient had septic CSVT associated with tuberculous meningitis (TBM). Radiological findings included brain parenchyma involvement (n=8), subdural hematoma (SDH) (n=1), subarachnoid haemorrhage (SAH) (n=1) and normal brain parenchyma (n=5). Multiple cerebral sinuses were involved in seven patients. Most common site of CSVT was observed in sigmoid sinus. Risk factors included hyperhomocystenemia (n=3), protein S deficiency (n=8), protein C deficiency (n=6) and antithrombin III deficiency (n=3) as primary hypercoagulable state. ANA positive was observed in one patient and four had history of alcohol use. All fifteen patients received low molecular weight heparin (LMWH) for 1 week along with bridging oral anticoagulant. None of the patients required intrasinus thrombolysis and decompression surgery. Average hospital stay was 9 days. All had modified Rankin scale (MRS) ≤ 2 at 6 months follow up.Conclusions: Prevalence of CSVT is higher than that reported from Asian studies. Younger age and male predominance was observed. Protein S deficiency was the major risk factor for CSVT.

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