scholarly journals Determining the prevalence of vestibular screening failures in pediatric cancer patients whose therapies include radiation to the head/neck and platin-based therapies: A pilot study

2018 ◽  
Vol 65 (6) ◽  
pp. e26992 ◽  
Author(s):  
Miranda L. Camet ◽  
Susan S. Hayashi ◽  
Belinda C. Sinks ◽  
Jennifer Henry ◽  
Katie Gettinger ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients ◽  
Head Neck

scholarly journals Real-time broad-range PCR versus blood culture. A prospective pilot study in pediatric cancer patients with fever and neutropenia

2007 ◽  
Vol 15 (6) ◽  
pp. 637-641 ◽  
Author(s):  
Roland A. Ammann ◽  
Franziska Zucol ◽  
Christoph Aebi ◽  
Felix K. Niggli ◽  
Thomas Kühne ◽  
...  
Keyword(s):  
Pilot Study ◽  
Blood Culture ◽  
Real Time ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Prospective Pilot Study ◽  
Pediatric Cancer Patients

scholarly journals Effect of radiotherapy on the gut microbiome in pediatric cancer patients: a pilot study

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7683 ◽  
Author(s):  
Nourhan Sahly ◽  
Ahmed Moustafa ◽  
Mohamed Zaghloul ◽  
Tamer Z. Salem
Keyword(s):  
Pilot Study ◽  
Sample Size ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Gut Microbiome ◽  
Small Sample ◽  
Response To Treatment ◽  
Microbial Composition ◽  
Pediatric Cancer Patients ◽  
The Impact

The incidence of pediatric cancer is lower than that of adult cancer worldwide. However, the former has detrimental side effects on the health of individuals, even after the cancer is cured, due to the impact of treatment on development. Recently, correlations have been made between the gut microbiome and cancer in several studies but only on adult participants. There is always a complication of dealing with pediatric cancer treatment protocols because they usually include a combination of chemotherapy, radiotherapy, and intensive prophylactic antibiotics. In the current study, a pilot study was conducted to analyze ten fecal samples from three pediatric cancer patients, suffering from rhabdomyosarcoma near their pelvic region, and two healthy individuals. A correlation between microbial composition and response to treatment was reported, in which the responders had generally a lower microbial diversity compared to non-responders. In addition, nucleotide changes and deletions in the tested 16S rRNA sequences post radiotherapy were detected. Despite the small sample size used in the experiments due to the uncommon rhabdomyosarcoma in children, the results can help in understanding the influence of radiotherapy on the gut microbiome in pediatric cancer patients. More work with larger sample size and different cancer types need to be conducted to understand the influence of radiotherapy on gut microbiome to mitigate the deleterious impact of radiation on treated children.

Anthracyclines Cause Endothelial Injury in Pediatric Cancer Patients: A Pilot Study

2006 ◽  
Vol 24 (6) ◽  
pp. 925-928 ◽  
Author(s):  
Amy Y. Chow ◽  
Clifford Chin ◽  
Gary Dahl ◽  
David N. Rosenthal
Keyword(s):  
Blood Pressure ◽  
Pilot Study ◽  
Cancer Patients ◽  
Brachial Artery ◽  
Pediatric Cancer ◽  
Animal Studies ◽  
Treated Group ◽  
Early Event ◽  
Pediatric Cancer Patients

Purpose The vascular endothelium plays a central role in the regulation of arterial vasomotor tone, releasing nitric oxide for vasodilation. Endothelial-dependent vasodilation can be assessed in vivo, using high resolution ultrasound to measure changes in diameter of the brachial artery. Animal studies have demonstrated that anthracyclines can damage the endothelium and impair the vasodilatory response of arteries; however, there are no comparable data in humans. This is a pilot study assessing endothelial toxicity from anthracyclines in pediatric cancer patients. Patients and Methods Fourteen control patients and 14 cancer patients (4 to 21 years) were studied. Cancer patients had completed chemotherapy containing no less than 300 mg/m2 of anthracyclines 2 to 60 months before study. Brachial artery diameters were measured at rest and 1 minute after blood pressure cuff occlusion. Brachial artery reactivity (BAR) was calculated as percent change between baseline and after cuff deflation measurements. Results were compared using unpaired, two-tailed t-test. Results Baseline characteristics, including age, percentage of females, blood pressure, and resting vessel diameters were similar between the two groups. BAR in the controls averaged 6.7% with a standard deviation (SD) of 3.3%, while BAR in patients receiving anthracyclines averaged 3.8% with an SD of 3.4%, demonstrating a significant decrease (P < .05) in vasomotor reactivity in the treated group. Conclusion These results suggest that anthracyclines cause impaired endothelial function, an important and newly recognized toxicity. Since endothelial dysfunction is an early event in atherogenesis, there may be important clinical implications from these findings. Further study is required to confirm these preliminary results in a larger cohort.

Quality of life in school-age pediatric cancer patients

2013 ◽  
Author(s):  
Fransisca M. Sidabutar ◽  
Anggie Regia Anandari ◽  
Ingrid Karli ◽  
Yusnita Katagori ◽  
Henny E. Wirawan
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
School Age ◽  
Pediatric Cancer Patients

Psychosocial Needs of Pediatric Cancer Patients in the Bronx

2007 ◽  
Author(s):  
Margaret M. Mannix ◽  
Nicole Furnari ◽  
Adam Rudolph ◽  
Karen M. Moody
Keyword(s):  
Cancer Patients ◽  
Pediatric Cancer ◽  
Psychosocial Needs ◽  
Pediatric Cancer Patients

Use of virtual reality as a distractor for painful procedures in pediatric cancer patients

2001 ◽  
Author(s):  
Barbara O. Rothbaum ◽  
Larry F. Hodges ◽  
Jonathan Gershon ◽  
Michael Briones ◽  
Melissa Pickering
Keyword(s):  
Virtual Reality ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients
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