scholarly journals Real-time broad-range PCR versus blood culture. A prospective pilot study in pediatric cancer patients with fever and neutropenia

2007 ◽  
Vol 15 (6) ◽  
pp. 637-641 ◽  
Author(s):  
Roland A. Ammann ◽  
Franziska Zucol ◽  
Christoph Aebi ◽  
Felix K. Niggli ◽  
Thomas Kühne ◽  
...  
Keyword(s):  
Pilot Study ◽  
Blood Culture ◽  
Real Time ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Prospective Pilot Study ◽  
Pediatric Cancer Patients

scholarly journals Determining the prevalence of vestibular screening failures in pediatric cancer patients whose therapies include radiation to the head/neck and platin-based therapies: A pilot study

2018 ◽  
Vol 65 (6) ◽  
pp. e26992 ◽  
Author(s):  
Miranda L. Camet ◽  
Susan S. Hayashi ◽  
Belinda C. Sinks ◽  
Jennifer Henry ◽  
Katie Gettinger ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients ◽  
Head Neck

scholarly journals Effect of radiotherapy on the gut microbiome in pediatric cancer patients: a pilot study

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7683 ◽  
Author(s):  
Nourhan Sahly ◽  
Ahmed Moustafa ◽  
Mohamed Zaghloul ◽  
Tamer Z. Salem
Keyword(s):  
Pilot Study ◽  
Sample Size ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Gut Microbiome ◽  
Small Sample ◽  
Response To Treatment ◽  
Microbial Composition ◽  
Pediatric Cancer Patients ◽  
The Impact

The incidence of pediatric cancer is lower than that of adult cancer worldwide. However, the former has detrimental side effects on the health of individuals, even after the cancer is cured, due to the impact of treatment on development. Recently, correlations have been made between the gut microbiome and cancer in several studies but only on adult participants. There is always a complication of dealing with pediatric cancer treatment protocols because they usually include a combination of chemotherapy, radiotherapy, and intensive prophylactic antibiotics. In the current study, a pilot study was conducted to analyze ten fecal samples from three pediatric cancer patients, suffering from rhabdomyosarcoma near their pelvic region, and two healthy individuals. A correlation between microbial composition and response to treatment was reported, in which the responders had generally a lower microbial diversity compared to non-responders. In addition, nucleotide changes and deletions in the tested 16S rRNA sequences post radiotherapy were detected. Despite the small sample size used in the experiments due to the uncommon rhabdomyosarcoma in children, the results can help in understanding the influence of radiotherapy on the gut microbiome in pediatric cancer patients. More work with larger sample size and different cancer types need to be conducted to understand the influence of radiotherapy on gut microbiome to mitigate the deleterious impact of radiation on treated children.

Antibiotic Lock Therapy with Linezolid for the Treatment of Persistent Catheter-Related Infection in Children with Cancer

2020 ◽  
Vol 15 (05) ◽  
pp. 238-241
Author(s):  
Neriman Sarı ◽  
Nurettin Okur ◽  
Selma Çakmakcı ◽  
Tekin Aksu ◽  
İnci Ergürhan İlhan
Keyword(s):  
Blood Culture ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Blood Cultures ◽  
Line Treatment ◽  
First Line ◽  
Pediatric Cancer Patients ◽  
Lock Therapy ◽  
Antibiotic Lock ◽  
First Line Treatment

Abstract Objective Central venous catheter (CVC) colonization is a common problem in the pediatric oncology department. Initial colonization of CVC by coagulase-negative staphylococci (CoNS), Staphylococcus aureus, and enterococci is followed by the growth of intraluminal biofilm formation, and results in antibiotic therapy failure. The removal of the old CVC and insertion of new CVC is a difficult and expensive procedure in small children with cancer. The present article aimed to study our treatment results of antibiotic lock therapy (ALT) with linezolid in pediatric cancer patients. Methods This study was planned as retrospective presentation of case series with eight pediatric cancer patients treated with 11 courses of systemic and linezolid lock therapy. Demographic information, clinical findings, laboratory data, blood culture results, complications, and outcome were collected for each patient retrospectively and descriptive statistical methods were used. Results Prior to treatment, peripheral and CVC blood culture results showed Staphylococcus epidermidis in seven patients and Staphylococcus hominis in four patients. All pathogens were susceptible to vancomycin and teicoplanin; first-line treatment was vancomycin in six and teicoplanin in five patients. After first-line treatment, peripheral blood cultures of all patients were negative, whereas blood cultures from CVC remained positive. During second-line therapy with linezolid, microbiological eradication was achieved on the fourth day of treatment in each patient. Median catheter survival time for all patients was 14 (range: 8–30) months. No side effects were observed during the treatment and no resistant organisms were documented. Conclusion Although multicentric prospective controlled trials will be required to provide more generalizable results, we suggest that systemic antibiotics combined with linezolid lock therapy used in pediatric cancer patients may be an effective option in treating catheter-related bloodstream infection (CRBSI) and prolonging CVC survival when CoNS are identified.

Anthracyclines Cause Endothelial Injury in Pediatric Cancer Patients: A Pilot Study

2006 ◽  
Vol 24 (6) ◽  
pp. 925-928 ◽  
Author(s):  
Amy Y. Chow ◽  
Clifford Chin ◽  
Gary Dahl ◽  
David N. Rosenthal
Keyword(s):  
Blood Pressure ◽  
Pilot Study ◽  
Cancer Patients ◽  
Brachial Artery ◽  
Pediatric Cancer ◽  
Animal Studies ◽  
Treated Group ◽  
Early Event ◽  
Pediatric Cancer Patients

Purpose The vascular endothelium plays a central role in the regulation of arterial vasomotor tone, releasing nitric oxide for vasodilation. Endothelial-dependent vasodilation can be assessed in vivo, using high resolution ultrasound to measure changes in diameter of the brachial artery. Animal studies have demonstrated that anthracyclines can damage the endothelium and impair the vasodilatory response of arteries; however, there are no comparable data in humans. This is a pilot study assessing endothelial toxicity from anthracyclines in pediatric cancer patients. Patients and Methods Fourteen control patients and 14 cancer patients (4 to 21 years) were studied. Cancer patients had completed chemotherapy containing no less than 300 mg/m2 of anthracyclines 2 to 60 months before study. Brachial artery diameters were measured at rest and 1 minute after blood pressure cuff occlusion. Brachial artery reactivity (BAR) was calculated as percent change between baseline and after cuff deflation measurements. Results were compared using unpaired, two-tailed t-test. Results Baseline characteristics, including age, percentage of females, blood pressure, and resting vessel diameters were similar between the two groups. BAR in the controls averaged 6.7% with a standard deviation (SD) of 3.3%, while BAR in patients receiving anthracyclines averaged 3.8% with an SD of 3.4%, demonstrating a significant decrease (P < .05) in vasomotor reactivity in the treated group. Conclusion These results suggest that anthracyclines cause impaired endothelial function, an important and newly recognized toxicity. Since endothelial dysfunction is an early event in atherogenesis, there may be important clinical implications from these findings. Further study is required to confirm these preliminary results in a larger cohort.

Quality of life in school-age pediatric cancer patients

2013 ◽  
Author(s):  
Fransisca M. Sidabutar ◽  
Anggie Regia Anandari ◽  
Ingrid Karli ◽  
Yusnita Katagori ◽  
Henny E. Wirawan
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
School Age ◽  
Pediatric Cancer Patients

Psychosocial Needs of Pediatric Cancer Patients in the Bronx

2007 ◽  
Author(s):  
Margaret M. Mannix ◽  
Nicole Furnari ◽  
Adam Rudolph ◽  
Karen M. Moody
Keyword(s):  
Cancer Patients ◽  
Pediatric Cancer ◽  
Psychosocial Needs ◽  
Pediatric Cancer Patients
Sign in / Sign up

Export Citation Format

Share Document