scholarly journals Effect of radiotherapy on the gut microbiome in pediatric cancer patients: a pilot study

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7683 ◽  
Author(s):  
Nourhan Sahly ◽  
Ahmed Moustafa ◽  
Mohamed Zaghloul ◽  
Tamer Z. Salem
Keyword(s):  
Pilot Study ◽  
Sample Size ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Gut Microbiome ◽  
Small Sample ◽  
Response To Treatment ◽  
Microbial Composition ◽  
Pediatric Cancer Patients ◽  
The Impact

The incidence of pediatric cancer is lower than that of adult cancer worldwide. However, the former has detrimental side effects on the health of individuals, even after the cancer is cured, due to the impact of treatment on development. Recently, correlations have been made between the gut microbiome and cancer in several studies but only on adult participants. There is always a complication of dealing with pediatric cancer treatment protocols because they usually include a combination of chemotherapy, radiotherapy, and intensive prophylactic antibiotics. In the current study, a pilot study was conducted to analyze ten fecal samples from three pediatric cancer patients, suffering from rhabdomyosarcoma near their pelvic region, and two healthy individuals. A correlation between microbial composition and response to treatment was reported, in which the responders had generally a lower microbial diversity compared to non-responders. In addition, nucleotide changes and deletions in the tested 16S rRNA sequences post radiotherapy were detected. Despite the small sample size used in the experiments due to the uncommon rhabdomyosarcoma in children, the results can help in understanding the influence of radiotherapy on the gut microbiome in pediatric cancer patients. More work with larger sample size and different cancer types need to be conducted to understand the influence of radiotherapy on gut microbiome to mitigate the deleterious impact of radiation on treated children.

scholarly journals Psychological Distress and the Impact of Social Support on Fathers and Mothers of Pediatric Cancer Patients: Long-Term Prospective Results

2005 ◽  
Vol 31 (8) ◽  
pp. 785-792 ◽  
Author(s):  
Barbara J. Wijnberg-Williams ◽  
Willem A. Kamps ◽  
Ed C. Klip ◽  
Josette E. H. M. Hoekstra-Weebers
Keyword(s):  
Social Support ◽  
Psychological Distress ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients ◽  
The Impact

scholarly journals Determining the prevalence of vestibular screening failures in pediatric cancer patients whose therapies include radiation to the head/neck and platin-based therapies: A pilot study

2018 ◽  
Vol 65 (6) ◽  
pp. e26992 ◽  
Author(s):  
Miranda L. Camet ◽  
Susan S. Hayashi ◽  
Belinda C. Sinks ◽  
Jennifer Henry ◽  
Katie Gettinger ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients ◽  
Head Neck

scholarly journals Real-time broad-range PCR versus blood culture. A prospective pilot study in pediatric cancer patients with fever and neutropenia

2007 ◽  
Vol 15 (6) ◽  
pp. 637-641 ◽  
Author(s):  
Roland A. Ammann ◽  
Franziska Zucol ◽  
Christoph Aebi ◽  
Felix K. Niggli ◽  
Thomas Kühne ◽  
...  
Keyword(s):  
Pilot Study ◽  
Blood Culture ◽  
Real Time ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Prospective Pilot Study ◽  
Pediatric Cancer Patients

Pre-COVID-19 food insecurity prevalence and risk factors in caregivers of pediatric cancer patients at a children’s cancer hospital.

2020 ◽  
Vol 38 (29_suppl) ◽  
pp. 205-205
Author(s):  
Stephanie J. Wells ◽  
Brandon Douglas Brown ◽  
Kris Michael Mahadeo ◽  
Keri L. Schadler ◽  
Joya Chandra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Food Insecurity ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Clinical Pathways ◽  
Education Level ◽  
Cancer Hospital ◽  
Pediatric Cancer Patients ◽  
The Impact

205 Background: Food insecurity (FI) affects 1 in 5 US households with children and is associated with malnutrition and poor diet quality in children. Malnutrition negatively impacts clinical trial outcomes, chemotherapy tolerance, and survival rate in cancer patients, who may be at higher FI risk given the financial toxicity of treatment. Thus, we aimed to assess FI prevalence and sociodemographics of pediatric patient caregivers at MD Anderson Cancer Center Children’s Cancer Hospital (MDACC-CCH) and to identify healthcare provider sociodemographics and FI practice considerations. Methods: We surveyed caregivers and providers at MDACC-CCH anonymously from December 2019 to January 2020. Caregiver surveys included sociodemographics and The Hunger Vital Sign FI screening tool. Oncologists and other providers were surveyed on FI-related practice considerations. Univariate relationships between known covariates and FI were explored using purposeful covariate selection and multivariable logistic regression to model variables associated with FI risk factors. Results: Baseline characteristics are listed in Table. Of 67 caregiver responses, 36% were positive for FI. Univariate analyses revealed that race, education level, spousal/child support, marital status, and household income were associated with FI status. Final logistic regression model indicated that race other than Non-Hispanic White and lower education level were positively associated with FI. Of 38 provider responses, 58% reported being knowledgeable about FI to some extent. No providers referred patients to community food access resources. Conclusions: In a small pilot study, FI is prevalent in families of pediatric cancer patients at MDACC-CCH and may be associated with race and education level. Further research is needed to assess the impact of the COVID-19 pandemic on FI in this population and to determine appropriate interventions and clinical pathways to improve FI status. [Table: see text]

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