Updated systematic review and meta-analysis of the predictive value of serum biomarkers in the assessment and management of fever during neutropenia in children with cancer

Background: For a woman with bleeding and threatened abortion, ultrasound scan is done to confirm the viability of the fetus; however, 10-15% of the embryos are eventually aborted. Distinguishing between women with good and poor prognosis can be a helpful approach. Objective: This study aimed to review the predictive value of Pregnancy-associated Plasma Protein A (PAPP-A) in relation to the diagnosis of fetal loss. Materials and Methods: The articles published in multiple databases including Web of Science, PubMed, MEDLINE, Scopus, and Persian databases such as ISC, Magiran, and IranMedx were searched for articles published until May 2019. MeSH terms was used for searching the databases including fetal loss OR pregnancy loss OR abortion OR miscarriage with the following word using AND; Pregnancy-Associated Plasma Protein- A OR PAPP-A. Two reviewers extracted data and recorded them in a pre-defined form and assessed the quality of articles using the Newcastle-Ottawa tool. Meta-analysis was done using the Comprehensive Meta-Analysis/2.0 software and MetaDisc. Results: A total number of 16 studies were eligible for the qualitative data synthesis, out of which 8 studies were included in the meta-analysis. All studies had high and medium quality. The forest plot analysis showed a sensitivity of 57% (95% CI: 53-63%), a specificity of 83% (95% CI: 80-85%), a positive likelihood ratio of 3.52 (95% CI: 2.44- 5.07), a negative likelihood ratio of 0.54 (95% CI: 0.37-0.79), and a diagnostic odds ratio of 6.95 (95% CI: 3.58-13.50). Conclusion: PAPP-A cannot be recommended on a routine basis for predicting fetal loss and still further research with a combination of other biomarkers is required. Key words: Pregnancy-associated plasma protein-A, Fetal loss, Pregnancy, Systematic review.

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Predictive value of neuron-specific enolase following moderate and severe traumatic brain injury: a systematic review and meta-analysis

Critical Care ◽

10.1186/cc10918 ◽

2012 ◽

Vol 16 (S1) ◽

Author(s):

E Mercier ◽

AF Turgeon ◽

A Boutin ◽

F Lauzier ◽

R Zarychanski ◽

...

Keyword(s):

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Severe Traumatic Brain Injury ◽

Predictive Value ◽

Meta Analysis ◽

Neuron Specific Enolase

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Adverse effects of chemotherapy on the teeth and surrounding tissues of children with cancer: A systematic review with meta-analysis

Oral Oncology ◽

10.1016/j.oraloncology.2018.06.001 ◽

2018 ◽

Vol 83 ◽

pp. 64-72 ◽

Cited By ~ 7

Author(s):

Dan Mike Busenhart ◽

Juliane Erb ◽

Georgios Rigakos ◽

Theodore Eliades ◽

Spyridon N. Papageorgiou

Keyword(s):

Systematic Review ◽

Adverse Effects ◽

Meta Analysis ◽

Children With Cancer

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Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis

Sarcoma ◽

10.1155/2020/7192347 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Marc El Beaino ◽

Daniel C. Jupiter ◽

Tarek Assi ◽

Elie Rassy ◽

Alexander J. Lazar ◽

...

Keyword(s):

Systematic Review ◽

Synovial Sarcoma ◽

Predictive Value ◽

Meta Analysis ◽

Diagnostic Value ◽

Cochrane Library ◽

Specific Marker ◽

Eligibility Criteria ◽

Depth Analysis ◽

The Mean

Background. Synovial sarcoma can present morphologically in multiple forms, including biphasic and monophasic subtypes. As a result, the histological diagnosis can sometimes be challenging. Transducin-Like Enhancer 1 (TLE1) is a transcriptional corepressor that normally is involved in embryogenesis and hematopoiesis but is also expressed in certain tumors. This systematic review examines the potential role of TLE1 as a diagnostic biomarker for the synovial sarcoma. Materials and Methods. A literature review and meta-analysis were conducted using the electronic databases Pubmed, the Cochrane Library, and Google Scholar. Thirteen studies met our eligibility criteria and were selected for in-depth analysis. Results. The mean sensitivity and specificity of TLE1 in detecting synovial sarcoma were 94% (95% CI 91%–97%) and 81% (95% CI 72%–91%), respectively, when all studies were aggregated together. The mean positive predictive value (PPV) of TLE1 was 75% (95% CI 62%–87%), whereas the negative predictive value (NPV) was 96% (95% CI 93%–98%). Conclusion. TLE1 is a sensitive and specific marker for synovial sarcoma that can aid in its diagnosis. Due to its involvement in several relevant signaling pathways, TLE1 might have direct relevance to the pathophysiology of the disease.

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