The influence of maternal opiate use in pregnancy on second trimester biochemical markers for Down syndrome

Abstract Objective: This study aims to determine whether it is possible to predict preeclampsia by comparing postpartum results and test results of the pregnant women diagnosed with preeclampsia, whose first and/or second trimester screening tests were accessible, and to demonstrate the predictability of severity and week of onset.Background: 204 patients underwent renal transplantation in our center and 84 of them were female. Five of our patients (one of them had two births) gave birth to a total of 6 pregnancies.Method: 135 patients were diagnosed with preeclampsia and their first and/or second trimester screening tests were accessible, and 366 control participants gave birth to a healthy baby between 37-41 weeks after standard follow-up period for pregnancy and their screening tests were also accessible.Results: The study results show that the first trimester maternal serum PAPP-A level is significantly low in preeclamptic pregnant women, and that the second trimester maternal serum AFP and hCG levels are significantly high and uE3 levels are significantly low The results also suggest that the first and second trimester Down syndrome biochemical markers can be used in preeclampsia screening.Conclusion: Among these markers, uE3 is the parameter which affects the possibility of preeclampsia the most. However, the first and second trimester Down syndrome biochemical markers are not effective in predicting the severity and onset week of preeclampsia.

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Down syndrome biochemical markers and screening for preeclampsia at first and second trimester: correlation with the week of onset and the severity

Prenatal Diagnosis ◽

10.1002/pd.1997 ◽

2008 ◽

Vol 28 (8) ◽

pp. 704-709 ◽

Cited By ~ 40

Author(s):

Jin Hee Kang ◽

Antonio Farina ◽

Ji Hyeon Park ◽

Sung Han Kim ◽

Ji Yeon Kim ◽

...

Keyword(s):

Down Syndrome ◽

Biochemical Markers ◽

Second Trimester

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False-Positive Maternal Serum Screens in the Second Trimester as Markers of Placentally Mediated Complications Later in Pregnancy: A Systematic Review and Meta-Analysis

Disease Markers ◽

10.1155/2021/5566234 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Christy L. Pylypjuk ◽

Joel Monarrez-Espino

Keyword(s):

Down Syndrome ◽

Preterm Birth ◽

Pregnancy Complications ◽

False Positive ◽

Meta Analysis ◽

Grey Literature ◽

Maternal Serum ◽

Growth Restriction ◽

Second Trimester ◽

In Pregnancy

Background. Multiple-marker, maternal serum screening (MSS) has been the cornerstone of prenatal diagnosis since the 1980s. While combinations of these markers are used to predict fetal risk of Down syndrome and other genetic conditions, there is some evidence that individual markers may also predict nongenetic pregnancy complications, particularly those related to placental dysfunction. The objective of this meta-analysis was to investigate the utility of false-positive, second-trimester MSS for Down syndrome as a marker of placentally mediated complications amongst singleton pregnancies globally. Methods. Electronic searches of PubMed, Medline, Embase, CINAHL, Web of Science, Scopus, and grey literature to 2019 were performed to identify observational studies comparing risk of pregnancy complications amongst pregnancies with false-positive MSS versus controls. A random-effects model of pooled odds ratios by outcome of interest (stillbirth, preeclampsia, fetal growth restriction, and preterm birth) and subgrouped by type of MSS test (double-, triple-, and quadruple-marker MSS) was used. Results. 16 studies enrolling 68515 pregnancies were included. There were increased odds of preeclampsia (OR 1.28, 95% CI 1.09-1.51) and stillbirth (OR 2.46, 95% CI 1.94-3.12) amongst pregnancies with false-positive MSS. There was no significant association with preterm birth or growth restriction. Conclusions. There is some evidence of an association between false-positive, second-trimester MSS for Down syndrome and increased odds of preeclampsia and stillbirth. Future large-scale prospective studies are still needed to best determine the predictive value of false-positive MSS as a marker of placentally mediated complications later in pregnancy and evaluate potential clinical interventions to reduce these risks.

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Second-trimester prenatal screening for Down syndrome and the relationship of maternal serum biochemical markers to pregnancy complications with adverse outcome

Prenatal Diagnosis ◽

10.1002/1097-0223(200008)20:8<652::aid-pd882>3.0.co;2-6 ◽

2000 ◽

Vol 20 (8) ◽

pp. 652-656 ◽

Cited By ~ 62

Author(s):

Kevin Spencer

Keyword(s):

Down Syndrome ◽

Pregnancy Complications ◽

Biochemical Markers ◽

Prenatal Screening ◽

Adverse Outcome ◽

Maternal Serum ◽

Second Trimester ◽

Serum Biochemical ◽

Relationship Of ◽

The Relationship

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Biochemical Markers of Hydronephrosis During Pregnancy

Revista de Chimie ◽

10.37358/rc.18.3.6173 ◽

2018 ◽

Vol 69 (3) ◽

pp. 674-677

Author(s):

Irina Negru ◽

Delia Hinganu ◽

Marius Valeriu Hinganu ◽

Catalin Pricop ◽

Virgil Bulimar ◽

...

Keyword(s):

Differential Diagnosis ◽

Pregnant Women ◽

Biochemical Markers ◽

Second Trimester ◽

Non Invasive ◽

Diagnostic Difficulties ◽

Biochemical Assessment ◽

In Pregnancy

Ureterohydronephrosis is a urological disease that can affect pregnant women in any trimester, but it also occur physiologically in the second trimester. The study included a group of 119 pregnant women diagnosed with ureterohydronephrosis. The diagnostic difficulties of the urological pathology in pregnancy are outweighed by the contribution of the biochemical assessment of patients, correlated with non-invasive imaging investigations. The results of the study highlight the peculiarities of these investigations in this group of patients and the possibilities of differential diagnosis.

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Could first- and second-trimester biochemical markers for Down syndrome have a role in predicting intrahepatic cholestasis of pregnancy?

Archives of Medical Science ◽

10.5114/aoms.2017.69865 ◽

2017 ◽

Cited By ~ 1

Author(s):

Ahter Tanay Tayyar ◽

Ahmet Tayyar ◽

Tolga Atakul ◽

Cigdem Abide Yayla ◽

Cetin Kilicci ◽

...

Keyword(s):

Down Syndrome ◽

Intrahepatic Cholestasis ◽

Biochemical Markers ◽

Intrahepatic Cholestasis Of Pregnancy ◽

Second Trimester ◽

Cholestasis Of Pregnancy

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Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination in an unselected population

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70046-8 ◽

2007 ◽

Vol 2007 ◽

pp. 59-61

Author(s):

L.P. Shulman

Keyword(s):

Down Syndrome ◽

Ultrasound Examination ◽

First Trimester ◽

Second Trimester ◽

Unselected Population

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First trimester ultrasound identifies more cases of Down syndrome than second trimester maternal serum screening and is more cost effective

PsycEXTRA Dataset ◽

10.1037/e556492006-009 ◽

2003 ◽

Keyword(s):

Down Syndrome ◽

Cost Effective ◽

First Trimester ◽

Maternal Serum ◽

Second Trimester ◽

Maternal Serum Screening ◽

Serum Screening ◽

First Trimester Ultrasound

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Does Active Smoking Influence the Second Trimester Biochemical Markers Concentrations?

Revista de Chimie ◽

10.37358/rc.17.10.5862 ◽

2017 ◽

Vol 68 (10) ◽

pp. 2234-2236

Author(s):

Dan Navolan ◽

Florin Birsasteanu ◽

Adrian Carabineanu ◽

Octavian Cretu ◽

Diana Liana Badiu ◽

...

Keyword(s):

Pregnant Woman ◽

Pregnant Women ◽

Cigarette Smoke ◽

Chorionic Gonadotropin ◽

Reference Values ◽

Biochemical Markers ◽

Smoking Status ◽

Active Smoking ◽

Second Trimester ◽

Harmful Effects

Cigarette smoke contains over 7000 different substances some of them exerting harmful effects on embryo and pregnant woman. Nowadays 15 % of adult people and around 10-15% of pregnant women smoke. Previous studies showed that cigarette smoke compounds could exert pharmacodinamic effects and influence some of the second trimester biochemical markers concentration. Therefore there is a need to adjust the reference values of second trimester markers depending of the smoker status. The aim of our study was to analyse which of the markers are influenced by smoking and whether the software used to calculate the risk for aneuploidies is able to counterbalance this influence. Alpha-fetoprotein (AFP), chorionic gonadotropin hormone (hCG) and free estriol (uE3) values were measured in second trimester sera of 1242 pregnant women: 1089 non-smokers and 153 smokers. Only hCG second trimester values were influenced by smoking whereas AFP and uE3 values were not. The correction of medians according to the smoking status was able to counterbalance this effect.

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Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?

Revista de Chimie ◽

10.37358/rc.17.5.5613 ◽

2017 ◽

Vol 68 (5) ◽

pp. 1070-1072

Author(s):

Dan Navolan ◽

Mirela Nicolov ◽

Simona Vladareanu ◽

Ioana Ciohat ◽

Marius Craina ◽

...

Keyword(s):

Pregnant Women ◽

Gestational Age ◽

Biochemical Markers ◽

Biochemical Marker ◽

Second Trimester ◽

Established Method ◽

Crown Rump Length ◽

The Difference ◽

Fetal Aneuploidies ◽

Singleton Pregnancies

Screening of fetal aneuploidies in early pregnancy is a well-established method in the materno-fetal medicine. The aim of our study was to analyze if the medians recommended by the manufacturers are adequate to perform an accurate screening or if there is a need for own laboratory medians calculation in second trimester biochemical marker screening.Sera were collected between 14 wp and 22 wp from 3374 singleton pregnancies. We analyzed three second trimester biochemical markers (AFP, hCG and free Estriol) concentration in all pregnant women and in a subgroup of pregnant women in which gestational age was determined based on crown-rump length. Our results showed that for all biochemical markers the difference between the manufacturer and the own calculated median was lower than 10% excepting the hCG value in the group of pregnant women in which the gestational age was determined on basis of crown-rump-length. Our results show it is recommended to replace the values of the median for hCG measurement with the own laboratory calculated medians. This does not seem to be necessary in the case of AFP and free Estriol measurement.

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