A simple model for the semicontinuous heterophase polymerization: Ethyl methacrylate as a case example

2019 ◽  
Vol 60 (2) ◽  
pp. 223-232
Author(s):  
Abraham G. Alvarado ◽  
Rosaura Hernández‐Montelongo ◽  
Martin Rabelero ◽  
Lourdes A. Pérez‐Carrillo ◽  
Jorge E. Puig ◽  
...  
Keyword(s):  
Simple Model ◽  
Ethyl Methacrylate ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

scholarly journals Effect of Monomer Dosing Rate in the Preparation of Mesoporous Polystyrene Nanoparticles by Semicontinuous Heterophase Polymerization

Molecules ◽  
2014 ◽  
Vol 20 (1) ◽  
pp. 52-69 ◽  
Author(s):  
Dalia Sosa ◽  
Lourdes Guillén ◽  
Hened Saade ◽  
Eduardo Mendizábal ◽  
Jorge Puig ◽  
...  
Keyword(s):  
Polystyrene Nanoparticles ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

Modeling the Semicontinuous Heterophase Polymerization for Synthesizing Poly(n -butyl methacrylate) Nanoparticles

2013 ◽  
Vol 7 (9) ◽  
pp. 440-452 ◽  
Author(s):  
María G. Pérez-García ◽  
Lourdes A. Pérez-Carrillo ◽  
Eduardo Mendizábal ◽  
Jorge E. Puig ◽  
Francisco López-Serrano
Keyword(s):  
Butyl Methacrylate ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

Semicontinuous heterophase polymerization under monomer starved conditions to prepare nanoparticles with narrow size distribution

2007 ◽  
Vol 45 (8) ◽  
pp. 1463-1473 ◽  
Author(s):  
Raquel Ledezma ◽  
M. Esther Treviño ◽  
Luis E. Elizalde ◽  
Lourdes A. Pérez-Carrillo ◽  
Eduardo Mendizábal ◽  
...  
Keyword(s):  
Size Distribution ◽  
Narrow Size Distribution ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

scholarly journals Synthesis, Characterization, and Drug Delivery from pH- and Thermoresponsive Poly(N-Isopropylacrylamide)/Chitosan Core/Shell Nanocomposites Made by Semicontinuous Heterophase Polymerization

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Abraham G. Alvarado ◽  
Andres Ortega ◽  
Lourdes A. Pérez-Carrillo ◽  
Israel Ceja ◽  
Martin Arellano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Crosslinking Agent ◽  
Core Shell ◽  
Ph Responsive ◽  
Doxycycline Hyclate ◽  
Shell Nanoparticles ◽  
Heterophase Polymerization ◽  
Heating And Cooling ◽  
Core Shell Nanoparticles ◽  
Semicontinuous Heterophase Polymerization

Temperature- and pH-responsive core/shell nanoparticles were prepared by semicontinuous heterophase polymerization of N-isopropylacrylamide (NIPA) in the presence of chitosan micelles for drug delivery purposes. Micelles of chitosan, formed in an acetic acid aqueous solution at 70°C containing potassium persulfate, were fed with N-isopropylacrylamide (NIPA) at a controlled rate, to produce PNIPA/chitosan core/shell nanoparticles of about 350 nm. Then, the crosslinking agent, glutaraldehyde, was added to crosslink the nanoparticles. These nanocomposites were temperature- and pH-responsive, which make them suitable as controlled drug releasing agents. The nanoparticles exhibit thermoreversibility to heating-and-cooling cycles and show different responses depending on the releasing medium’s pH. Drug delivery tests were performed, employing as a model drug, doxycycline hyclate.

scholarly journals Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
J. A. Balleño ◽  
A. P. Mendizábal-Ruiz ◽  
H. Saade ◽  
R. Díaz de León-Gómez ◽  
E. Mendizábal ◽  
...  
Keyword(s):  
Surfactant Concentration ◽  
Uv Spectroscopy ◽  
Drug Loading ◽  
Weibull Model ◽  
Heterophase Polymerization ◽  
Transmission Electron ◽  
Ethyl Cyanoacrylate ◽  
Release Data ◽  
Ibuprofen Release ◽  
Semicontinuous Heterophase Polymerization

Ibuprofen-loaded poly(ethyl cyanoacrylate) nanoparticles were prepared by semicontinuous heterophase polymerization of ethyl cyanoacrylate in the presence of ibuprofen; different surfactant concentration, pH, and temperature were used. Particle size was measured by quasi-light scattering and transmission electron microscopy, while the amount of drug released was determined by UV spectroscopy. Nanoparticles with diameters between 10 and 58 nm, loaded with ibuprofen, were obtained. The smallest particles and the higher drug loading were obtained at the highest pH tested. The analysis of the release data showed that the drug release profiles correspond to the Weibull model. Moreover, it was found that most of the ibuprofen is released within the first 80–120 min; initially the release rate is slow, but then it increases to finally decrease. This behavior contrasts with the reported burst of drug concentration in the plasma after oral administration of IB.

SEMICONTINUOUS HETEROPHASE POLYMERIZATION AS A TOOL FOR PREPARING ULTRAFINE NANOPARTICLES OF IBUPROFEN-POLY(METHYL METHACRYLATE)

NANO ◽  
2014 ◽  
Vol 09 (06) ◽  
pp. 1450060 ◽  
Author(s):  
HENED SAADE ◽  
JESUS CEPEDA GARZA ◽  
MARIA LUISA LOPEZ-QUINTANILLA ◽  
FRANCISCO ENRIQUEZ-MEDRANO ◽  
SALVADOR FERNANDEZ ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Average Diameter ◽  
Scanning Calorimetry ◽  
Poly Methyl Methacrylate ◽  
Heterophase Polymerization ◽  
Hydrophobic Polymers ◽  
Scanning Transmission ◽  
Insoluble Drugs ◽  
20 Nm ◽  
Semicontinuous Heterophase Polymerization

Ibuprofen-loaded poly(methyl methacrylate) nanoparticles with mean diameters smaller than 20 nm were prepared by a novel method. This consists in carrying out a semicontinuous heterophase polymerization, in which a solution of drug-monomer is added on a micellar solution at an appropriate dosing rate. Scanning transmission electron microscopy (STEM) measurements showed number-average diameters in the range 16–19 nm with 1.14–1.15 in polydispersity, determined as the ratio of weight-average to number-average diameter. Drug contents in nanoparticles close to 24% were determined by UV-Vis spectrophotometry, confirming the results obtained from a procedure that combines latex filtration and quasielastic light scattering (QLS) measurements. Differential scanning calorimetry (CDSC) determinations suggest that at the ibuprofen contents attained in this study, crystals and dispersed molecules of the drug coexist inside the nanoparticles. Based on the relative simplicity of the process it is expected that its use will be adopted to prepare ultrafine nanoparticles composed of different hydrophobic polymers and water insoluble drugs.

Semicontinuous Heterophase Polymerization of Methyl and Hexyl Methacrylates to Produce Latexes with High Nanoparticles Content

2014 ◽  
Vol 51 (2) ◽  
pp. 144-155 ◽  
Author(s):  
M. G. Pérez-García ◽  
A. G. Alvarado ◽  
M. Rabelero ◽  
M. Arellano ◽  
L. A. Pérez-Carrillo ◽  
...  
Keyword(s):  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

Mesoporous polystyrene nanoparticles synthesized by semicontinuous heterophase polymerization

2010 ◽  
Vol 67 (2) ◽  
pp. 217-226 ◽  
Author(s):  
O. Esquivel ◽  
M. E. Treviño ◽  
H. Saade ◽  
J. E. Puig ◽  
E. Mendizábal ◽  
...  
Keyword(s):  
Polystyrene Nanoparticles ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

scholarly journals Preparation and Loading with Rifampicin of Sub-50 nm Poly(ethyl cyanoacrylate) Nanoparticles by Semicontinuous Heterophase Polymerization

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
H. Saade ◽  
C. Barrera ◽  
R. Guerrero ◽  
E. Mendizábal ◽  
J. E. Puig ◽  
...  
Keyword(s):  
Drug Release ◽  
Aqueous Dispersions ◽  
Molecular Weights ◽  
Heterophase Polymerization ◽  
Release Times ◽  
Addition Rate ◽  
Nanoparticle Structure ◽  
Ethyl Cyanoacrylate ◽  
Two Populations ◽  
Semicontinuous Heterophase Polymerization

We report the preparation of poly(ethyl cyanoacrylate) (PECA) nanoparticles by semicontinuous heterophase polymerization carried out at monomer starved conditions at three monomer addition rates. Particles in the nanometer range were obtained, the size of which diminishes with decreasing monomer addition rate as shown by the fact that particles with mean diameters of ca. 42 and 30 nm were obtained at the faster and intermediate dosing rates, respectively, whereas two populations of particles, one of 15.5 and the other of 36 nm in mean diameters, were produced at the slower dosing rate. The obtained molecular weights were from 2,200 to 3,500 g/mol, depending on the addition rate, which are typical of the anionic polymerizations of cyanoacrylates in aqueous dispersions at low pHs. The rifampicin (RIF) loading into the nanoparticles was successful since the entire drug added was incorporated. The drug release study carried out at pH of 7.2 indicated a faster release from the free RIF at intermediate and larger release times as expected since, in the nanoparticles, first the drug has to diffuse through the nanoparticle structure. The comparison of several drug release models indicates that the RIF release from PECA nanoparticles follows that of Higuchi.

On the Modeling of the Semicontinuous Heterophase Polymerization of Alkyl Methacrylates With Different Water Solubilities

2015 ◽  
Vol 9 (2) ◽  
pp. 114-124 ◽  
Author(s):  
María G. Pérez García ◽  
Abraham G. Alvarado ◽  
Lourdes A. Pérez-Carrillo ◽  
Jorge E. Puig ◽  
Francisco López-Serrano ◽  
...  
Keyword(s):  
Heterophase Polymerization ◽  
Alkyl Methacrylates ◽  
Semicontinuous Heterophase Polymerization
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