scholarly journals Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
J. A. Balleño ◽  
A. P. Mendizábal-Ruiz ◽  
H. Saade ◽  
R. Díaz de León-Gómez ◽  
E. Mendizábal ◽  
...  
Keyword(s):  
Surfactant Concentration ◽  
Uv Spectroscopy ◽  
Drug Loading ◽  
Weibull Model ◽  
Heterophase Polymerization ◽  
Transmission Electron ◽  
Ethyl Cyanoacrylate ◽  
Release Data ◽  
Ibuprofen Release ◽  
Semicontinuous Heterophase Polymerization

Ibuprofen-loaded poly(ethyl cyanoacrylate) nanoparticles were prepared by semicontinuous heterophase polymerization of ethyl cyanoacrylate in the presence of ibuprofen; different surfactant concentration, pH, and temperature were used. Particle size was measured by quasi-light scattering and transmission electron microscopy, while the amount of drug released was determined by UV spectroscopy. Nanoparticles with diameters between 10 and 58 nm, loaded with ibuprofen, were obtained. The smallest particles and the higher drug loading were obtained at the highest pH tested. The analysis of the release data showed that the drug release profiles correspond to the Weibull model. Moreover, it was found that most of the ibuprofen is released within the first 80–120 min; initially the release rate is slow, but then it increases to finally decrease. This behavior contrasts with the reported burst of drug concentration in the plasma after oral administration of IB.

scholarly journals Preparation and Loading with Rifampicin of Sub-50 nm Poly(ethyl cyanoacrylate) Nanoparticles by Semicontinuous Heterophase Polymerization

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
H. Saade ◽  
C. Barrera ◽  
R. Guerrero ◽  
E. Mendizábal ◽  
J. E. Puig ◽  
...  
Keyword(s):  
Drug Release ◽  
Aqueous Dispersions ◽  
Molecular Weights ◽  
Heterophase Polymerization ◽  
Release Times ◽  
Addition Rate ◽  
Nanoparticle Structure ◽  
Ethyl Cyanoacrylate ◽  
Two Populations ◽  
Semicontinuous Heterophase Polymerization

We report the preparation of poly(ethyl cyanoacrylate) (PECA) nanoparticles by semicontinuous heterophase polymerization carried out at monomer starved conditions at three monomer addition rates. Particles in the nanometer range were obtained, the size of which diminishes with decreasing monomer addition rate as shown by the fact that particles with mean diameters of ca. 42 and 30 nm were obtained at the faster and intermediate dosing rates, respectively, whereas two populations of particles, one of 15.5 and the other of 36 nm in mean diameters, were produced at the slower dosing rate. The obtained molecular weights were from 2,200 to 3,500 g/mol, depending on the addition rate, which are typical of the anionic polymerizations of cyanoacrylates in aqueous dispersions at low pHs. The rifampicin (RIF) loading into the nanoparticles was successful since the entire drug added was incorporated. The drug release study carried out at pH of 7.2 indicated a faster release from the free RIF at intermediate and larger release times as expected since, in the nanoparticles, first the drug has to diffuse through the nanoparticle structure. The comparison of several drug release models indicates that the RIF release from PECA nanoparticles follows that of Higuchi.

scholarly journals Optimization of the Preparation Process for an Oral Phytantriol-Based Amphotericin B Cubosomes

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Zhiwen Yang ◽  
Xinsheng Peng ◽  
Yinhe Tan ◽  
Meiwan Chen ◽  
Xingqi Zhu ◽  
...  
Keyword(s):  
Particle Size ◽  
Amphotericin B ◽  
Liquid Crystalline ◽  
Uv Spectroscopy ◽  
Drug Loading ◽  
Narrow Particle Size Distribution ◽  
Drug Solubility ◽  
X Ray Scattering ◽  
Transmission Electron ◽  
Bicontinuous Cubic

In order to develop an oral formation of Amphotericin B (AmB) using phytantriol- (PYT-) based cubosomes with desirable properties, homogenization conditions were firstly investigated to determine their effects on the morphological and dimensional characteristics of cubosomes. Under the optimized homogenization conditions of 1200 bar for 9 cycles, cubosomes with reproducible, narrow particle size distribution and a mean particle size of 256.9 nm ± 4.9 nm were obtained. The structure of the dispersed cubosomes was revealed by SAXS (small-angle X-ray scattering) and Cryo-TEM (cryogenic transmission electron microscopy) as a bicontinuous cubic liquid crystalline phase with Pn3m geometry. To overcome the poor drug solubility and increase the drug-loading rate, a solubilization method was firstly used to develop cubosomes containing AmB. The encapsulation efficiency determined by HPLC assay was87.8%±3.4%, and UV spectroscopy and stability studies in simulated gastric fluids further confirmed that AmB was successfully encapsulated in cubosomes.

scholarly journals Effect of pH and Monomer Dosing Rate in the Anionic Polymerization of Ethyl Cyanoacrylate in Semicontinuous Operation

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hened Saade ◽  
Suleidi Torres ◽  
Cynthia Barrera ◽  
Julieta Sánchez ◽  
Yolanda Garza ◽  
...  
Keyword(s):  
Anionic Polymerization ◽  
Scanning Transmission Electron Microscopy ◽  
Average Diameter ◽  
Transmission Electron ◽  
Scanning Transmission ◽  
Initial Ph ◽  
Ethyl Cyanoacrylate ◽  
Stable Particles ◽  
Solids Content ◽  
Semicontinuous Heterophase Polymerization

Nanoparticles of poly(ethyl cyanoacrylate) with more than 10% solids content were prepared by semicontinuous heterophase polymerization at monomer-starved conditions varying the initial pH in the interval of 1–1.75 and at two monomer dosing rates. Measurements by scanning-transmission electron microscopy allowed us to identify an inverse dependence of particle size on pH. Furthermore, all the polymerizations conducted at the slower monomer dosing rate rendered two particle populations, with the larger one formed from the aggregation of a fraction of the smaller particles. It was believed that the so slow addition of the monomer caused the formation of very small but instable particles, thereby a fraction of which aggregated to reduce the total interface particles-aqueous phase, increasing the latex stability. An increase in the monomer dosing rate led to larger and more stable particles in such way that only one population of nanoparticles with around 40 nm in average diameter was obtained.

scholarly journals Effect of Monomer Dosing Rate in the Preparation of Mesoporous Polystyrene Nanoparticles by Semicontinuous Heterophase Polymerization

Molecules ◽  
2014 ◽  
Vol 20 (1) ◽  
pp. 52-69 ◽  
Author(s):  
Dalia Sosa ◽  
Lourdes Guillén ◽  
Hened Saade ◽  
Eduardo Mendizábal ◽  
Jorge Puig ◽  
...  
Keyword(s):  
Polystyrene Nanoparticles ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

Modeling the Semicontinuous Heterophase Polymerization for Synthesizing Poly(n -butyl methacrylate) Nanoparticles

2013 ◽  
Vol 7 (9) ◽  
pp. 440-452 ◽  
Author(s):  
María G. Pérez-García ◽  
Lourdes A. Pérez-Carrillo ◽  
Eduardo Mendizábal ◽  
Jorge E. Puig ◽  
Francisco López-Serrano
Keyword(s):  
Butyl Methacrylate ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

Surfactant Assisted Hydroxyapatite Nanoparticles: Drug Loading and In Vitro Leaching Kinetics and Antimicrobial Properties

2019 ◽  
Vol 19 (11) ◽  
pp. 7198-7204 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Ravichandran Kulandaivelu ◽  
Devendrapandi Santhana Panneer ◽  
S. Vivekananthan ◽  
Suresh Sagadevan ◽  
...  
Keyword(s):  
Drug Loading ◽  
Antimicrobial Properties ◽  
Chemical Precipitation ◽  
Leaching Kinetics ◽  
E Coli ◽  
Brij 35 ◽  
Transmission Electron ◽  
Lauryl Ether ◽  
Polyoxyethylene Lauryl Ether

In the present investigation, extremely fine Hydroxyapatite (HAP) powder was prepared through chemical precipitation technique under the influence of a nonionic surfactant (Brij 35-Polyoxyethylene lauryl ether). The samples were sintered at 800 °C to obtain highly pure HAP phase. The functional group present in the HAP powder was confirmed by using Fourier transform infra-red (FTIR) spectroscopy. The change in Phase transformation, the crystallite size and the percentage of crystallinity of the synthesized sample were studied by X-ray diffractometer technique. The Field Emission Scanning Electron Microscope (FESEM) and High-resolution transmission electron microscopy (HRTEM) were used for the structural analysis of porous rod-shaped HAP crystal. Further, drug loading and In Vitro leaching kinetics were conducted for antibiotics-ciproflaxin (CPF). Antimicrobial activity against S. aureus (Gram-positive bacterium) and E. coli (Gram-negative bacterium) was executed for pure HAP as well as for drug loaded HAP.

scholarly journals Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 195 ◽  
Author(s):  
Catalina Paula Spatarelu ◽  
Anita-Laura (Radu) Chiriac ◽  
Bogdan Cursaru ◽  
Tanta-Verona Iordache ◽  
Ana-Mihaela Gavrila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Natural Zeolite ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Preparation Conditions ◽  
Transmission Electron ◽  
Poly Ethylene

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

scholarly journals A Novel Synthesis of Fe3O4@SiO2@Au@Porous SiO2 Structure for NIR Irradiation-Induced DOX Release and Cancer Treatment

Dose-Response ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 155932582090666
Author(s):  
Meng Yang ◽  
Wenhua Yang ◽  
Liang Chen ◽  
Mingjian Ding ◽  
Chenhao Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
Drug Loading ◽  
Thermal Conversion ◽  
Au Nanoparticle ◽  
Cell Viability Assay ◽  
Viability Assay ◽  
Transmission Electron ◽  
Adsorption Desorption

Doxorubicin (DOX) alone or in combination has been widely used for numerous cancers, including breast, lung, bladder, and so on. In this article, a core/shell/shell structured Fe3O4@SiO2@Au@porous SiO2 particles for the drug delivery and release of DOX was demonstrated, with the aid of near-infrared irradiation. Fe3O4 was used to direct the transportation and delivery of the drug-loaded composite to the target tissues and organs under an external magnetic field, the first layer of SiO2 was used for Au nanoparticle attachment, Au acted as the agent for light–thermal conversion, and the porous SiO2 was used to load DOX. The morphology of the nanoparticles was studied by transmission electron microscopy, and the porous structure was characterized by N2 adsorption/desorption curves. The drug delivery system displayed high drug loading capacity, and the release behavior was largely impacted by the environmental pH. Furthermore, the cytotoxicity of Fe3O4@SiO2@Au@porous SiO2 and DOX loaded Fe3O4@SiO2@Au@porous SiO2 was studied through in vitro 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell viability assay.

Synergistic effect of cinnamaldehyde on the thermal inactivation of Listeria monocytogenes in ground pork

2019 ◽  
Vol 26 (1) ◽  
pp. 28-37 ◽  
Author(s):  
Yuexia Wang ◽  
Xiaoyan Li ◽  
Yangliu Lu ◽  
Jianan Wang ◽  
Biao Suo
Keyword(s):  
Listeria Monocytogenes ◽  
Thermal Inactivation ◽  
Meat Product ◽  
Membrane Integrity ◽  
Weibull Model ◽  
Mathematical Tool ◽  
Membrane Rupture ◽  
Transmission Electron ◽  
Ground Pork ◽  
Cytoplasmic Content

The aim of this study was to statistically evaluate the effect of a naturally food-derived cinnamaldehyde on the thermal inactivation of Listeria monocytogenes in ground pork. This study combined four concentrations of cinnamaldehyde (0, 0.1, 0.5, and 1.0% vol/wt) and four temperatures (55, 60, 65, and 70 ℃) to predict the thermal inactivation curves of L. monocytogenes. The Weibull model successfully described the primary thermal inactivation using the Integrated Pathogen Modeling Program. These results statistically proposed that the cinnamaldehyde supplementation in ground pork attenuates the thermo-tolerance of L. monocytogenes. The time for achieving a 5-log10 reduction of L. monocytogenes declined from 28.14 to 17.35 min at 55 ℃ when the ground pork sample was supplemented by 1% cinnamaldehyde, while the time declined from 1.95 to 0.34 min at 70 ℃. Thereafter, based on the 5.0-log10 lethality, secondary models were fitted by a selected polynomial model. The transmission electron microscopy revealed that cinnamaldehyde causes serious damage to membrane integrity and increases the occurrence of cell membrane rupture and leakage of cytoplasmic content under thermal treatment. Our model represents a mathematical tool that will help meat-product manufacturers to improve the efficacy of thermal processing ground pork supplemented with cinnamaldehyde.

Preparation and Spectral Properties of PVP-Modified ZnO Nanorods

2008 ◽  
Vol 368-372 ◽  
pp. 329-332 ◽  
Author(s):  
Yang Feng Huang ◽  
Han Ning Xiao ◽  
Shu Guang Chen
Keyword(s):  
Electron Microscopy ◽  
Hydrothermal Reaction ◽  
Uv Spectroscopy ◽  
Zno Nanorods ◽  
X Ray Diffraction ◽  
X Ray ◽  
Uv Emission ◽  
Transmission Electron ◽  
Light Region ◽  
Uv Absorption Spectrum

ZnO nanorods were prepared by a hydrothermal reaction in the presence or absence of PVP (polyvinyl pyrrolidone). The obtained products were characterized by means of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, UV-Vis absorption (UV) spectroscopy and photoluminescence (PL) spectroscopy. The results suggest that PVP plays an important role in the preparation of ZnO nanorods. The UV absorption spectrum showed PVP increases the UV-shielding ability but doesn’t influence the transparency in the visible light region. A weak UV emission at 353 nm of PL spectra exhibit the surface of ZnO nanorods is passivated and oxygen-related defects is supplied by PVP.

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