NR3C2 Genotype is Associated with Response to Spironolactone in Diastolic Heart Failure Patients from the Aldo‐DHF Trial

2021 ◽  
Author(s):  
Leanne Dumeny ◽  
Orly Vardeny ◽  
Frank Edelmann ◽  
Burkert Pieske ◽  
Julio D. Duarte ◽  
...  
Keyword(s):  
Heart Failure ◽  
Diastolic Heart Failure ◽  
Heart Failure Patients

Abstract 18599: Clinical Assessment of Hemodynamic Profiles Predict Readmission and Mortality in Diastolic Heart Failure Patients

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Mohammed Siddiqui ◽  
Salpy V Pamboukian ◽  
Jose A Tallaj ◽  
Michael Falola ◽  
Sula Mazimba
Keyword(s):  
Heart Failure ◽  
Clinical Assessment ◽  
Diastolic Heart Failure ◽  
Clinical Care ◽  
Systolic Heart Failure ◽  
Health Care Expenditures ◽  
Left Ventricular ◽  
Readmission Rates ◽  
Heart Failure Patients ◽  
Increased Risk

Background: Reducing 30 day readmission rates for patients with heart failure (HF) has been a recent focus of lowering health care expenditures. Hemodynamic profiles (HP) have been associated with clinical outcomes in chronic systolic HF. The relationship of HP to outcomes in acute decompensated diastolic HF (DHF) has not been defined. Methods: This case-control study of 1892 DHF patients discharged alive from an academic hospital between 2002-2012 with left ventricular function greater or equal to 45% were categorized into 4 groups: Profile A, no evidence of congestion and hypoperfusion (dry-warm); Profile B, congestion with adequate perfusion (wet-warm); Profile C, congestion with hypoperfusion (wet-cold); and Profile L, hypoperfusion without congestion (dry-cold). All cause readmissions at 30 days and 1 year and mortality at 30 days and 1 year were examined. Statistical analysis using multivariable Cox Proportional hazard model was performed adjusting for demographic, clinical, care and hospital characteristics. Results: Of the 1892 patients, 1196 (63%) were females; mean age was 68 (±14) years. There were 724(38%), 1000 (53%), 88(5%) and 80 (4%) patients in the hemodynamic profiles A, B, C and L respectively. Profiles B and C were associated with an increased risk for 30-day all-cause HF readmission compared to profiles A and L: Hazard ratio (HR) [1.38 (95% C.I 1.17-1.61)], [1.39 (95% C.I 1.18-1.62)] for B and C profiles respectively. Profiles C and L were associated with increased mortality at 1 year: HR [1.46 (95% CI 1.06-1.89)] and [1.31 (95% CI 1.01-1.64)] for A and L profiles respectively (Table). Conclusions: Clinical assessment of HP can help identify DHF patients at increased risk of readmission and mortality, similar to systolic heart failure patients.

Ventilatory Responses of Older Systolic and Diastolic Heart Failure Patients

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S385
Author(s):  
Jordan E. Irwin ◽  
Peter H. Brubaker ◽  
Brian Moore ◽  
Dalane W. Kitzman
Keyword(s):  
Heart Failure ◽  
Diastolic Heart Failure ◽  
Heart Failure Patients ◽  
Ventilatory Responses

Comparison of VE/VCO2 Slope in Older Systolic and Diastolic Heart Failure Patients and Age-Matched Healthy Controls

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S361
Author(s):  
Brian Moore ◽  
Peter H. Brubaker ◽  
Kathryn P. Stewart ◽  
Dalane W. Kitzman
Keyword(s):  
Heart Failure ◽  
Diastolic Heart Failure ◽  
Healthy Controls ◽  
Heart Failure Patients

Acute Bi-Ventricular Pacing Reduces Systolic and Diastolic Dyssynchrony in Diastolic Heart Failure Patients

2008 ◽  
Vol 14 (6) ◽  
pp. S22
Author(s):  
Yi-Chih Wang ◽  
Chih-Chieh Yu ◽  
Kathryn Hilpisch ◽  
Rodolphe P. Katra ◽  
Jiunn-Lee Lin
Keyword(s):  
Heart Failure ◽  
Diastolic Heart Failure ◽  
Ventricular Pacing ◽  
Heart Failure Patients

scholarly journals Serum Magnesium, Calcium and Phosphorus status in Heart Failure patients attending tertiary care center of Nepal

2019 ◽  
Vol 2 (3) ◽  
pp. 130-136
Author(s):  
Bijaya Gautam ◽  
Laxman Banstola ◽  
Ritu Bashyal
Keyword(s):  
Heart Failure ◽  
Serum Sodium ◽  
Diastolic Heart Failure ◽  
Serum Magnesium ◽  
Care Center ◽  
Tertiary Care ◽  
Systolic Heart Failure ◽  
Serum Levels ◽  
Electrolyte Imbalance ◽  
Heart Failure Patients

Background: Lack of proper diet and use of different medications in heart failure contributes to electrolyte imbalance. Due to absence of routine measurement, their abnormalities are not recognized. This study is an attempt to portrait a picture of serum levels of electrolytes in heart failure patients Materials and Methods: 102 heart failure patients were enrolled in this study over 6 months period. Serum levels of magnesium, calcium, phosphorus, sodium and albumin were measured. SPSS ver. 20.0 was used to analyze the data. Analysis of Variance was used to find mean differences and Pearson’s correlation was used to establish the correlation. Results: Majority of patient fell under New York Heart Association (NYHA) class II and had isolated systolic heart failure. Mean serum values of sodium and magnesium were below the reference range. Mean values of serum sodium, magnesium and corrected calcium was less in patients receiving diuretics and digitalis. Likewise, serum phosphorus was more with diuretics and digitalis use. Also, serum sodium was less in Acetylcholine Eseterose (ACE) inhibitors use. Isolated diastolic heart failure patients had least serum calcium values. Although, serum sodium and magnesium value in heart failure patients was positively correlated, was not statistically significant. Conclusion: This study showed that low serum sodium and magnesium values are frequently associated in heart failure. Disturbances in other serum electrolytes could also be other cause of complications in heart failure which are not under routine investigation. Identification and correction of these disturbances could have significant impact. However, further studies are required to reinforce this idea.  

scholarly journals Tissue doppler imaging for estimation of left ventricular filling pressure in patients with systolic and diastolic heart failure: a comparative simultaneous doppler catheterization study

2020 ◽  
Vol 7 (2) ◽  
pp. 319
Author(s):  
Manohar J. Suranagi ◽  
K. Subramanyam ◽  
K. S. Subramani ◽  
K. H. Srinivasa
Keyword(s):  
Heart Failure ◽  
Tissue Doppler Imaging ◽  
Diastolic Heart Failure ◽  
Systolic Heart Failure ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Filling Pressure ◽  
Doppler Imaging ◽  
Heart Failure Patients ◽  
Mitral Annular Velocity

Background: Noninvasive assessment of diastolic filling by Doppler echocardiography provides important information about left ventricular (LV) status in selected subsets of patients. This study was designed to assess whether the lateral mitral annular velocity as assessed by tissue Doppler imaging is associated with invasive measures of diastolic LV performance in patients with diastolic and systolic heart failure. Aim of the study was to compare the diagnostic accuracy of lateral mitral annular E/E′ as an estimate of LV filling pressure with invasive LVEDP measurement in subjects with systolic or purely diastolic heart failure.Methods: Total 100 patients were studied, 50 patients with diastolic heart failure and 50 patients with systolic heart failure in patients undergoing diagnostic coronary angiogram. Detailed 2D Echocardiography, Trans mitral Doppler and Tissue Doppler velocities of lateral mitral annulus was obtained. The ratio of peak mitral velocity (E) to lateral mitral annular velocity (E′) by TDI (E/E′) was calculated.Results: The ratio of E/E′ in diastolic group was 13.4±4.9 and in systolic group it was 13.7±5.2. The mean LVEDP in diastolic heart failure patients was 14.3±4.5 and 14.2±4.9 in systolic heart failure patients. The ratio of E/E′ showed a better correlation with LVEDP. E/E′ <8 accurately predicted normal LVEDP, and E/E′ >15 identified increased LVEDP ≥15mmHg.Conclusions: E/E′ is a reliable estimate of LV filling pressures in subjects with systolic and diastolic heart failure. In subjects with diastolic heart failure, E/E′ seems helpful to identify those with truly elevated LV filling pressures. In patients with diastolic heart failure and normal E/E′, a search for other causes of symptoms (pulmonary disease, obesity and so forth) may be warranted.

Effects Of Enalapril On Ventilatory Responses To Exercise In Older Diastolic Heart Failure Patients

2009 ◽  
Vol 41 ◽  
pp. 25
Author(s):  
Jordan E. Irwin ◽  
Peter H. Brubaker ◽  
C Vemulapalli ◽  
J. Brian Moore ◽  
Dalane W. Kitzman
Keyword(s):  
Heart Failure ◽  
Diastolic Heart Failure ◽  
Heart Failure Patients ◽  
Ventilatory Responses
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