scholarly journals Structural proteomics and protein complexes – special issue

PROTEOMICS ◽  
2021 ◽  
Vol 21 (21-22) ◽  
pp. 2000286
Author(s):  
Helen J. Cooper ◽  
Aneika C. Leney
Keyword(s):  
Protein Complexes ◽  
Structural Proteomics ◽  
Special Issue

Nuclear import of spliceosomal snRNPsThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell.

2006 ◽  
Vol 84 (3-4) ◽  
pp. 367-376 ◽  
Author(s):  
Christiane Rollenhagen ◽  
Nelly Panté
Keyword(s):  
Cell Nucleus ◽  
Nuclear Import ◽  
Current Knowledge ◽  
Protein Complexes ◽  
Special Issue ◽  
A Cell ◽  
Rna Maturation ◽  
Small Nuclear Ribonucleoproteins ◽  
Selection Of

Uridine-rich small nuclear ribonucleoproteins (U snRNPs) are the building units of the spliceosome. These RNA and protein complexes assemble in the cytoplasm. After proper assembly and RNA maturation, mature U snRNPs are imported into the cell nucleus, where they take part in the splicing process. In this paper we review the current knowledge of how U snRNPs enter the nucleus.

Structural Proteomics Applied to Plant Membrane Protein Complexes

2020 ◽  
Vol 25 (9) ◽  
pp. 945-946
Author(s):  
Pascal Albanese ◽  
Sem Tamara ◽  
Richard A. Scheltema ◽  
Cristina Pagliano
Keyword(s):  
Membrane Protein ◽  
Protein Complexes ◽  
Structural Proteomics ◽  
Membrane Protein Complexes

scholarly journals Bottom-up Structural Proteomics: Cryo-EM of Protein Complexes Enriched from the Cellular Milieu

2020 ◽  
Vol 118 (3) ◽  
pp. 291a
Author(s):  
Chi-Min Ho ◽  
Xiaorun Li ◽  
Mason Lai ◽  
Thomas Terwilliger ◽  
Josh Beck ◽  
...  
Keyword(s):  
Protein Complexes ◽  
Structural Proteomics ◽  
Bottom Up

scholarly journals Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu

2019 ◽  
Vol 17 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Chi-Min Ho ◽  
Xiaorun Li ◽  
Mason Lai ◽  
Thomas C. Terwilliger ◽  
Josh R. Beck ◽  
...  
Keyword(s):  
Protein Complexes ◽  
Structural Proteomics ◽  
Bottom Up

scholarly journals Proteomics: The protein complement of the genome

2003 ◽  
Vol 25 (1) ◽  
pp. 7-9
Author(s):  
Hannes Ponstingl ◽  
Janet M. Thornton
Keyword(s):  
Messenger Rna ◽  
Protein Separation ◽  
Large Scale ◽  
Protein Complexes ◽  
Protein Isoforms ◽  
Structural Proteomics ◽  
Protein Markers ◽  
Proteomics Data ◽  
Single Experiment ◽  
Large Sets

Recent advances in protein separation technology and mass spectrometry (MS) have enabled the systematic identification and quantification of large sets of proteins from an organelle, cell type or organism. In principle, protein isoforms, enzymically modified variants and protein complexes can be studied, for instance, at a certain stage in development or in response to stress or more subtle changes of the environment. An important pre-clinical application is the search for protein markers in body fluids for diagnostic purposes. Such proteomics studies can be performed increasingly at high-throughput rates that are reminiscent of those of genomic sequencing or the monitoring of messenger RNA levels. Thus, large sets of proteins can be monitored simultaneously in a single experiment. Proteomics data will increasingly be followed up by investigations of the three-dimensional structures of proteins and protein complexes at atomic detail in large-scale structural proteomics projects. We attempt in this article to give a flavour of what to us seem important experimental developments and to point to links with bioinformatics resources where appropriate.

scholarly journals Integrating mass spectrometry of intact protein complexes into structural proteomics

PROTEOMICS ◽  
2012 ◽  
Vol 12 (10) ◽  
pp. 1547-1564 ◽  
Author(s):  
Suk-Joon Hyung ◽  
Brandon T. Ruotolo
Keyword(s):  
Mass Spectrometry ◽  
Protein Complexes ◽  
Structural Proteomics ◽  
Intact Protein

scholarly journals [Special Issue: Fact Databases and Freewares] DPClus: A Density-periphery Based Graph Clustering Software Mainly Focused on Detection of Protein Complexes in Interaction Networks

2006 ◽  
Vol 7 ◽  
pp. 150-156 ◽  
Author(s):  
Md. Altaf-Ul Amin ◽  
Hisashi Tsuji ◽  
Ken Kurokawa ◽  
Hiroko Asahi ◽  
Yoko Shinbo ◽  
...  
Keyword(s):  
Protein Complexes ◽  
Graph Clustering ◽  
Interaction Networks ◽  
Special Issue

scholarly journals Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”

2021 ◽  
Vol 22 (6) ◽  
pp. 3008
Author(s):  
Young-Su Yi ◽  
Miyong Yun
Keyword(s):  
Drug Targets ◽  
Inflammatory Responses ◽  
Protein Complexes ◽  
The Body ◽  
Human Diseases ◽  
Inflammasome Activation ◽  
Special Issue ◽  
Intracellular Protein ◽  
Inflammatory Molecules ◽  
Pro Inflammatory Cytokines

Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular protein complexes consisting of pattern recognition receptors and inflammatory molecules. Inflammasomes are activated in response to various ligands, leading to the caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18 and the gasdermin D-mediated pyroptosis, an inflammatory form of cell death. Previous studies have demonstrated that inflammasome activation is a key determinant of inflammatory responses and many human diseases; therefore, inflammasomes have been attracted much attention as critical drug targets to prevent and treat various human diseases.

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