Clinical characteristics of Korean pediatric patients critically ill with influenza A (H1N1) virus

2010 ◽  
Vol 45 (10) ◽  
pp. 1014-1020 ◽  
Author(s):  
Soo Youn Shin ◽  
Joon Hyung Kim ◽  
Hyun Su Kim ◽  
Young A Kang ◽  
Ha Gyung Lee ◽  
...  
Keyword(s):  
Critically Ill ◽  
Influenza A ◽  
Clinical Characteristics ◽  
Pediatric Patients ◽  
H1n1 Virus ◽  
Influenza A H1n1

scholarly journals New influenza A(H1N1) virus infections in France, April – May 2009

2009 ◽  
Vol 14 (21) ◽  
Author(s):  
Collective New influenza A(H1N1) investigation teams*
Keyword(s):  
North America ◽  
Active Surveillance ◽  
Influenza A ◽  
Clinical Characteristics ◽  
H1n1 Virus ◽  
Virus Infections ◽  
Influenza A H1n1 ◽  
Set Up

Since the emergence of a new influenza A(H1N1) virus in North America and its international spread, an active surveillance of cases of infection due to this virus has been set up in France in order to undertake appropriate measures to slow down the spread of the new virus. This report describes the epidemiological and clinical characteristics of the 16 laboratory confirmed cases diagnosed in France as of 20 May 2009.

Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit

2018 ◽  
Vol 48 ◽  
pp. 172-177 ◽  
Author(s):  
José Garnacho-Montero ◽  
Cristina León-Moya ◽  
Antonio Gutiérrez-Pizarraya ◽  
Angel Arenzana-Seisdedos ◽  
Loreto Vidaur ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Influenza A ◽  
Clinical Characteristics ◽  
H1n1 Virus ◽  
Related Risk ◽  
Influenza A H1n1 ◽  
Immunosuppressed Patients

scholarly journals Clinical characteristics of fatalities due to influenza A (H1N1) virus in Mexico

Thorax ◽  
2010 ◽  
Vol 65 (6) ◽  
pp. 505-509 ◽  
Author(s):  
G. Fajardo-Dolci ◽  
R. Gutierrez-Vega ◽  
H. Arboleya-Casanova ◽  
A. Villalobos ◽  
K. S. Wilson ◽  
...  
Keyword(s):  
Influenza A ◽  
Clinical Characteristics ◽  
H1n1 Virus ◽  
Influenza A H1n1

Emergence of oseltamivir-resistant influenza A H1N1 virus during the 2007–2008 winter season in Luxembourg: Clinical characteristics and epidemiology

2009 ◽  
Vol 84 (1) ◽  
pp. 91-94 ◽  
Author(s):  
Joël Mossong ◽  
Matthias Opp ◽  
Nancy Gerloff ◽  
Patrick Hau ◽  
Jacques Kremer ◽  
...  
Keyword(s):  
Influenza A ◽  
Clinical Characteristics ◽  
H1n1 Virus ◽  
Winter Season ◽  
Influenza A H1n1

scholarly journals Immunophenotype Expressions and Cytokine Profiles of Influenza A H1N1 Virus Infection in Pediatric Patients in 2009

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Shih-Min Wang ◽  
Yu-Ting Liao ◽  
Yu-Shiang Hu ◽  
Tzong-Shiann Ho ◽  
Ching-Fen Shen ◽  
...  
Keyword(s):  
Influenza A ◽  
Pediatric Patients ◽  
Mononuclear Cells ◽  
H1n1 Virus ◽  
Influenza Pandemic ◽  
Influenza Infection ◽  
Plasma Concentrations ◽  
Pulmonary Complications ◽  
Cytokine Profiles ◽  
Influenza A H1n1

Background. A novel swine-origin influenza A H1N1 virus (S-OIV) caused human infection and acute respiratory illness in 2009, resulting in an influenza pandemic.Objectives. This study characterized the immune responses of S-OIV infection in pediatric patients at risk of pulmonary complications.Methods. All enrolled pediatric patients were confirmed virologically for S-OIV infection in 2009-2010, prospectively. Changes in cellular immunophenotypes were analyzed using flow cytometry. Plasma cytokine levels associated with S-OIV infection by pulmonary and without pulmonary complications were measured using cytokine cytometric bead assay kits.Results. A total of 85 patients with a mean age of 10.3 years were recruited. The level of C-reactive protein (CRP) was high in patients exhibiting pulmonary complications. The percentage of cellular immunophenotypes did not change between patients with and without pulmonary complications. The absolute numbers of peripheral blood mononuclear cells (PBMC), CD3, CD8, and CD16CD56 decreased with acute S-OIV pulmonary complications. Acute influenza infection with pulmonary complications was associated with high plasma concentrations of IL-1β, IL-6, IL-12, and IFN-γ.Conclusion. Immunophenotype studies have reported variability in immune response to the severity of S-OIV infections. Acute phase cytokine profiles of the 2009 S-OIV infection might have contributed to the pathogenesis of the pulmonary complications.

scholarly journals Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection

2012 ◽  
Vol 70 (5) ◽  
pp. 325-329 ◽  
Author(s):  
Paulo José Lorenzoni ◽  
Cláudia Suemi Kamoi Kay ◽  
Rosana Herminia Scola ◽  
Hipólito Carraro Júnior ◽  
Lineu Cesar Werneck
Keyword(s):  
Critically Ill ◽  
Muscle Biopsy ◽  
Critically Ill Patients ◽  
Influenza A ◽  
H1n1 Virus ◽  
Inflammatory Myopathy ◽  
H1n1 Infection ◽  
Influenza A H1n1 ◽  
2009 H1n1 ◽  
Muscle Biopsies

Higher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection.

scholarly journals Use of Intravenous Zanamivir after Development of Oseltamivir Resistance in a Critically Ill Immunosuppressed Child Infected with 2009 Pandemic Influenza A (H1N1) Virus

2010 ◽  
Vol 50 (11) ◽  
pp. 1493-1496 ◽  
Author(s):  
Daniel E. Dulek ◽  
John V. Williams ◽  
C. Buddy Creech ◽  
Alynna K. Schulert ◽  
Haydar A. Frangoul ◽  
...  
Keyword(s):  
Critically Ill ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Oseltamivir Resistance ◽  
Influenza A H1n1
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