scholarly journals Erb‐(IL10) 2 induces abscopal antitumor effects of radiotherapy through the activation and recruitment of lymph node CD8 + T cells

2021 ◽  
Author(s):  
Yimin Yao ◽  
Ziwei Qi ◽  
Qingqing Zhu ◽  
Qi Zhao ◽  
Zheng Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Cd8 T Cells ◽  
Antitumor Effects

scholarly journals Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillance

2019 ◽  
Vol 15 (3) ◽  
pp. e1007633 ◽  
Author(s):  
Jossef F. Osborn ◽  
Samuel J. Hobbs ◽  
Jana L. Mooster ◽  
Tahsin N. Khan ◽  
Augustus M. Kilgore ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Cd8 T Cells ◽  
Skin Infection ◽  
Central Memory ◽  
Memory Cd8 T Cells

scholarly journals Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Antonio P Baptista ◽  
Ramon Roozendaal ◽  
Rogier M Reijmers ◽  
Jasper J Koning ◽  
Wendy W Unger ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Cd8 T Cells ◽  
Stromal Cells ◽  
Transplant Rejection ◽  
Mhc Ii ◽  
Self Antigen ◽  
Lymph Node Stromal Cells

Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8+ T cells and MHC-II-dependent anergy of CD4+ T cells. In this study, we show that MHC-II expression on lymph node stromal cells is additionally required for homeostatic maintenance of regulatory T cells (Tregs) and maintenance of immune quiescence. In the absence of MHC-II expression in lymph node transplants, i.e. on lymph node stromal cells, CD4+ as well as CD8+ T cells became activated, ultimately resulting in transplant rejection. MHC-II self-antigen presentation by lymph node stromal cells allowed the non-proliferative maintenance of antigen-specific Tregs and constrained antigen-specific immunity. Altogether, our results reveal a novel mechanism by which lymph node stromal cells regulate peripheral immunity.

Abstract 526: Tumor-draining lymph node irradiation reduces tumor-infiltrating stem-like CD8+T-cells and abrogates the abscopal effect

2019 ◽  
Author(s):  
Zachary S. Buchwald ◽  
Tahseen H. Nasti ◽  
Christiane S. Eberhardt ◽  
Andreas Wieland ◽  
David Lawson ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Cd8 T Cells ◽  
Abscopal Effect ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node ◽  
Lymph Node Irradiation

scholarly journals Increased Antitumor Effects Using IL-2 with Anti–TGF-β Reveals Competition between Mouse NK and CD8 T Cells

2014 ◽  
Vol 193 (4) ◽  
pp. 1709-1716 ◽  
Author(s):  
Maite Alvarez ◽  
Myriam N. Bouchlaka ◽  
Gail D. Sckisel ◽  
Can M. Sungur ◽  
Mingyi Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Antitumor Effects

scholarly journals CRTAM Confers Late-Stage Activation of CD8+ T Cells to Regulate Retention within Lymph Node

2009 ◽  
Vol 183 (7) ◽  
pp. 4220-4228 ◽  
Author(s):  
Arata Takeuchi ◽  
Yasushi Itoh ◽  
Akiko Takumi ◽  
Chitose Ishihara ◽  
Noriko Arase ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Cd8 T Cells ◽  
Late Stage

scholarly journals CD8+ T cells with high TGF‑β1 expression cause lymph node fibrosis following HIV infection

2018 ◽  
Author(s):  
Lei Huang ◽  
Jianning Deng ◽  
Wen Xu ◽  
Hongbo Wang ◽  
Lei Shi ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Hiv Infection ◽  
Cd8 T Cells ◽  
Tgf Β1

Cytotoxic CD8 + T-cells in lymph-node follicle centres after HIV-1 infection? [reply]

AIDS ◽  
1992 ◽  
Vol 6 (3) ◽  
pp. 334 ◽  
Author(s):  
J. D. Laman ◽  
A. J. M. van den Eertwegh
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Cd8 T Cells ◽  
Hiv 1

scholarly journals Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys

Blood ◽  
2000 ◽  
Vol 96 (4) ◽  
pp. 1474-1479 ◽  
Author(s):  
Marcelo J. Kuroda ◽  
Jörn E. Schmitz ◽  
Aruna Seth ◽  
Ronald S. Veazey ◽  
Christine E. Nickerson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Lymph Node ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Cd8 T Cells ◽  
Rhesus Monkeys ◽  
Cd8 T Lymphocytes ◽  
Tetramer Binding ◽  
Immunodeficiency Virus

Major histocompatibility class I–peptide tetramer technology and simian immunodeficiency virus of macaques (SIVmac)-infected rhesus monkeys were used to clarify the distribution of acquired immunodeficiency syndrome virus-specific cytotoxic T lymphocytes (CTL) in secondary lymphoid organs and to assess the relationship between these CTL and the extent of viral replication in the various anatomic compartments. SIVmac Gag epitope-specific CD8+ T cells were evaluated in the spleen, bone marrow, tonsils, thymus, and 5 different lymph node compartments of 4 SIVmac-infected rhesus monkeys. The average percentage of CD8+ T lymphocytes that bound this tetramer in all the different lymph node compartments was similar to that in peripheral blood lymphocytes in individual monkeys. The percentage of CD8+ T cells that bound the tetramer in the thymus was uniformly low in the monkeys. However, the percentage of CD8+ T cells that bound the tetramer in bone marrow and spleen was consistently higher than that seen in lymph nodes and peripheral blood. The phenotypic profile of the tetramer-binding CD8+ T lymphocytes in the different lymphoid compartments was similar, showing a high expression of activation-associated adhesion molecules and a low level expression of naive T-cell–associated molecules. Surprisingly, no correlation was evident between the percentage of tetramer-binding CD8+ T lymphocytes and the magnitude of the cell-associated SIV RNA level in each lymphoid compartment of individual monkeys. These studies suggest that a dynamic process of trafficking may obscure the tendency of CTL to localize in particular regional lymph nodes or that some lymphoid organs may provide milieus that are particularly conducive to CTL expansion.

scholarly journals Fractional Laser Treatment Boosts Systemic Anti-Tumor Immunity in Combination with OX40 Agonist and PD-1 Blockade

2021 ◽  
Author(s):  
Masayoshi Kawakubo ◽  
Josh Glahn ◽  
Shadmehr Demehri ◽  
Dieter Manstein
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
T Cell ◽  
Tumor Growth ◽  
Triple Therapy ◽  
Co2 Laser ◽  
Cd8 T Cells ◽  
Flow Cytometric Analysis ◽  
Antigen Specificity ◽  
Cell Immunity

While ablative fractional photothermolysis (aFP) with a 10,600 nm CO2 laser is employed for a wide variety of dermatologic conditions, its applications in oncology are relatively unexplored. Building off our previous work, we investigated the effect of unilateral aFP treatment in combination with anti-PD-1 blocking antibody and OX40 agonist on bilateral tumor growth and remission. A CT26 wild type (CT26WT) colon carcinoma cell line was established bilaterally on the hind flanks of a standardized mouse model and tumor characteristics were investigated on aFP treated and untreated sides. Remarkably, triple therapy with fractional CO2 laser in combination with anti-PD-1 antibodies and OX40 agonists resulted in significantly slower tumor growth and complete remissions on bilateral tumors. Flow cytometric analysis showed the triple treatments elicited an increase of granzyme B+ CD8+T cells due to synergistic effect of aFP treatment and the checkpoint molecules, including the induction of CD103+ CCR7+ dendritic cells (DCs) in aFP-treated tumor by aFP treatment, XCR1+ DCs in drainage lymph node by anti-PD-1 inhibitor and OX40+ Ki67+ CD8+ T cells in the lymph node by OX40 agonist. Triple therapy-mediated tumor regression and survival was abrogated upon CD8+ T cell depletion. Importantly, when two mismatched cancer cells were implanted into mice, the effect of the triple therapy on distant tumor was abrogated, showing antigen specificity of the T cell immunity induced by triple therapy. This study highlights the efficacy of aFP a novel adjuvant for current cancer immunotherapeutics.

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