Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein

The Prostate ◽  
2006 ◽  
Vol 66 (14) ◽  
pp. 1542-1555 ◽  
Author(s):  
Lara H. El Touny ◽  
Partha P. Banerjee
Keyword(s):  
Growth Inhibition ◽  
Cancer Cells ◽  
Cyclin B1 ◽  
Cdc 2

MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells

Pharmacology ◽  
2018 ◽  
Vol 102 (5-6) ◽  
pp. 262-271 ◽  
Author(s):  
Chih-Hsin Lee ◽  
Yuan-Feng Lin ◽  
Yen-Chou Chen ◽  
Shuit-Mun Wong ◽  
Shu-Hui Juan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Cyclin B1 ◽  
M Cell ◽  
Apoptotic Pathway ◽  
Tubulin Inhibitors ◽  
Ht29 Cells

We previously synthesized new tubulin inhibitors, MPT0B169 and MPT0B002, which induced growth inhibition and apoptosis in leukemia cells. However, their effects on solid tumor cells have not been determined. In this study, we investigated the effects of MPT0B169 and MPT0B002 on glioblastoma, breast, lung, and colorectal cancer (CRC) cell lines. A cell viability analysis showed that MPT0B169 and MPT0B002 were more effective in inhibiting the proliferation of COLO205 and HT29 CRC cells than U87MG and GBM8401 glioblastoma, MCF-7 and MDA-MB-231 breast cancer, and A549 lung cancer cells. MPT0B169 and MPT0B002 inhibited growth of COLO205 and HT29 cells in dose- and time-dependent manners. A colony-formation assay confirmed the growth inhibitory effects of MPT0B169 and MPT0B002 on COLO205 and HT29 cells. MPT0B169 and MPT0B002 disrupted tubulin polymerization and arrested the cell cycle at the G2/M phase, with a concomitant increase of the cyclin B1 level. MPT0B169 and MPT0B002 induced apoptosis, accompanied by induction of the intrinsic apoptotic pathway, as shown by a reduction in the caspase-9 level and increases in cleaved caspase-3 and cleaved PARP. These results suggest that MPT0B169 and MPT0B002, new tubulin inhibitors, induced growth inhibition, G2/M arrest, and apoptosis in COLO205 and HT29 cells, and they could potentially be anticancer agents for CRC cells.

Downregulation of cyclin B1 inhibits proliferation of breast cancer cells

2005 ◽  
Vol 127 (04) ◽  
Author(s):  
J Yuan ◽  
I Androic ◽  
A Kraemer ◽  
M Kaufmann ◽  
K Strebhardt
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cyclin B1

Cyclin B1 transcriptional repression in colon cancer cells: Dual pathways of regulation

2001 ◽  
Vol 120 (5) ◽  
pp. A292
Author(s):  
Sonia Y. Archer ◽  
H.J. Kim ◽  
Jennifer Johnson ◽  
Richard A. Hodin
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Transcriptional Repression ◽  
Cyclin B1 ◽  
Colon Cancer Cells

scholarly journals Blockage of bone marrow kinase in chromosome X enhances ABC294640-induced growth inhibition and apoptosis of colorectal cancer cells

2018 ◽  
Vol 17 (5) ◽  
pp. 761
Author(s):  
Ruifang Jin ◽  
Zhoufeng Chen ◽  
Haibo Xue ◽  
Mengjun Chen
Keyword(s):  
Colorectal Cancer ◽  
Bone Marrow ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Chromosome X ◽  
Colorectal Cancer Cells

scholarly journals BI-69A11 enhances susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt

2014 ◽  
Vol 111 (1) ◽  
pp. 101-111 ◽  
Author(s):  
I Pal ◽  
S Sarkar ◽  
S Rajput ◽  
K K Dey ◽  
S Chakraborty ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Colon Cancer Cells

scholarly journals NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Wei-Jan Huang ◽  
Yu-Chih Liang ◽  
Shuang-En Chuang ◽  
Li-Ling Chi ◽  
Chi-Yun Lee ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Xenograft Model ◽  
Cyclin B1 ◽  
Dependent Manner ◽  
Cell Cycle Regulators ◽  
Anticancer Activities ◽  
Gene Expressions

HDAC inhibitors (HDACis) have been developed as promising anticancer agents in recent years. In this study, we synthesized and characterized a novel HDACi, termed NBM-HD-1. This agent was derived from the semisynthesis of propolin G, isolated from Taiwanese green propolis (TGP), and was shown to be a potent suppressor of tumor cell growth in human breast cancer cells (MCF-7 and MDA-MB-231) and rat glioma cells (C6), with an IC50ranging from 8.5 to 10.3 μM. Western blot demonstrated that levels of p21(Waf1/Cip1), gelsolin, Ac-histone 4, and Ac-tubulin markedly increased after treatment of cancer cells with NBM-HD-1. After NBM-HD-1 treatment for 1–4 h, p-PTEN and p-AKT levels were markedly decreased. Furthermore, we also found the anticancer activities of NBM-HD-1 in regulating cell cycle regulators. Treatment with NBM-HD-1,p21(Waf1/Cip1)gene expression had markedly increased whilecyclin B1andD1gene expressions had markedly decreased. On the other hand, we found that NBM-HD-1 increased the expressions of tumor-suppressor genep53in a dose-dependent manner. Finally, we showed that NBM-HD-1 exhibited potent antitumor activity in a xenograft model. In conclusion, this study demonstrated that this compound, NBM-HD-1, is a novel and potent HDACi with anticancer activityin vitroandin vivo.

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