scholarly journals ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor

2015 ◽  
Vol 3 (2) ◽  
pp. e00123 ◽  
Author(s):  
Swen Seeland ◽  
Hélène Kettiger ◽  
Mark Murphy ◽  
Alexander Treiber ◽  
Jasmin Giller ◽  
...  
Keyword(s):  
P2x7 Receptor ◽  
Cellular Stress ◽  
Mitochondrial Toxicity ◽  
Purinergic P2x7 Receptor ◽  
In Cells

Mitochondrial Toxicity of Selected Micropollutants, Their Mixtures, and Surface Water Samples Measured by the Oxygen Consumption Rate in Cells

2019 ◽  
Vol 38 (5) ◽  
pp. 1000-1011 ◽  
Author(s):  
Maximilian E. Müller ◽  
Sofia Vikstrom ◽  
Maria König ◽  
Rita Schlichting ◽  
Christiane Zarfl ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Surface Water ◽  
Water Samples ◽  
Oxygen Consumption Rate ◽  
Consumption Rate ◽  
Mitochondrial Toxicity ◽  
Surface Water Samples ◽  
In Cells

scholarly journals Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment

2019 ◽  
Vol 14 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Giorgia Scarpellino ◽  
Tullio Genova ◽  
Luca Munaron
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Progression ◽  
P2x7 Receptor ◽  
Purinergic Receptor ◽  
Purinergic Signalling ◽  
Cancer Therapies ◽  
Cell Functions ◽  
Anti Cancer ◽  
Purinergic P2x7 Receptor ◽  
And Function

Background: Purinergic signalling is involved in several physiological and pathophysiological processes. P2X7 Receptor (P2X7R) is a calcium-permeable ion channel that is gaining interest as a potential therapeutic target for the treatment of different diseases including inflammation, pain, psychiatric disorders and cancer. P2X7R is ubiquitously expressed and sensitive to high ATP levels, usually found in tumor microenvironment. P2X7R regulates several cell functions, from migration to cell death, but its selective contribution to tumor progression remains controversial.Objective:Current review was conducted to check involvement of P2X7R use in cancer treatment.Methods:We review the most recent patents focused on the use of P2X7R in the treatment of cancer.Results:P2X7R is an intriguing purinergic receptor that plays different roles in tumor progression.Conclusion:Powerful strategies able to selectively interfere with its expression and function should reveal helpful in the development of new anti-cancer therapies.

scholarly journals miR-150 Promotes Human Breast Cancer Growth and Malignant Behavior by Targeting the Pro-Apoptotic Purinergic P2X7 Receptor

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e80707 ◽  
Author(s):  
Songyin Huang ◽  
Yongsong Chen ◽  
Wei Wu ◽  
Nengyong Ouyang ◽  
Jianing Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
P2x7 Receptor ◽  
Cancer Growth ◽  
Human Breast ◽  
Purinergic P2x7 Receptor ◽  
Breast Cancer Growth ◽  
Malignant Behavior

Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

2009 ◽  
Vol 17 (14) ◽  
pp. 4861-4865 ◽  
Author(s):  
Hendra Gunosewoyo ◽  
Mark J. Coster ◽  
Maxwell R. Bennett ◽  
Michael Kassiou
Keyword(s):  
P2x7 Receptor ◽  
Receptor Antagonists ◽  
Biological Screening ◽  
Purinergic P2x7 Receptor

Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: A mouse model study

Immunobiology ◽  
2013 ◽  
Vol 218 (8) ◽  
pp. 1104-1112 ◽  
Author(s):  
André A. Santos ◽  
Valnês Rodrigues-Junior ◽  
Rafael F. Zanin ◽  
Thiago J. Borges ◽  
Cristina Bonorino ◽  
...  
Keyword(s):  
Mouse Model ◽  
P2x7 Receptor ◽  
Tuberculosis Infection ◽  
Interaction Mechanisms ◽  
Host Interaction ◽  
Model Study ◽  
Purinergic P2x7 Receptor
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