Eleutheroside B‐loaded poly (lactic‐ co ‐glycolic acid) nanoparticles protect against renal fibrosis via Smad3‐dependent mechanism

2021 ◽  
Author(s):  
Xiaohui Chen ◽  
Qixia Liu ◽  
Jing Yang ◽  
Min Kan ◽  
Rui Jin ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Glycolic Acid ◽  
Eleutheroside B ◽  
Dependent Mechanism

scholarly journals SAT-192 LOSS OF MACROPHAGE-SPECIFIC TLR4 INHIBITS OBSTRUCTIVE RENAL FIBROSIS BY BLOCKING MACROPHAGE-TO-MYOFIBROBLAST TRANSITION VIA A BAMBI-DEPENDENT MECHANISM

2019 ◽  
Vol 4 (7) ◽  
pp. S88
Author(s):  
F. Yang ◽  
X.R. Huang ◽  
W.H. Yiu ◽  
S. Tang ◽  
H.Y. Lan
Keyword(s):  
Renal Fibrosis ◽  
Dependent Mechanism

The adiponectin paralog CTRP9 but not CTRP7 mediates anti-oxidative effects in adult rat cardiomyocytes through an AMPK, adiponectin receptor and calreticulin dependent mechanism

2015 ◽  
Vol 10 (S 01) ◽  
Author(s):  
L Li ◽  
D Stumpp ◽  
B Siegler ◽  
M Micoogullari ◽  
B Niemann ◽  
...  
Keyword(s):  
Adiponectin Receptor ◽  
Rat Cardiomyocytes ◽  
Adult Rat ◽  
Oxidative Effects ◽  
Dependent Mechanism

Platelet Mobilization Induced by PAF and Its Role in the Thrombocytosis Triggered by Adrenaline in Rats

1989 ◽  
Vol 62 (04) ◽  
pp. 1107-1111 ◽  
Author(s):  
Hugo C Castro-Faria-Neto ◽  
Patricia T Bozza ◽  
Marco A Martins ◽  
Paulo M F L Dias ◽  
Patricia M R Silva ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Blood Samples ◽  
Platelet Counts ◽  
Platelet Number ◽  
Edta Solution ◽  
Web 2086 ◽  
Dependent Mechanism

SummaryThe injection of PAP (6 μg/kg, i. v.) induced, in rats, haemoconcentration accompanied by an increase in the platelet number, as attested by the counts of platelets in blood samples diluted in formalin-free EDTA solution. This increase was significant at 15 min, peaked from 1 to 4 h and returned to basal levels 24 h after the lipid administration. The release of platelets induced by PAP was inhibited dose-dependently by specific PAP receptor antagonists such as WEB 2086 (0.5-2 mg/kg), BN 52021 and 48740 RP (5-25 mg/kg). Furthermore, platelet mobilization was clearly impaired in splenectomized animals stimulated by PAP, whereas thrombocytopenia and haemoconcentration by the same stimulus were intact. It was also noted that a second injection of PAP, 24 h after the initial stimulation with the lipid, failed to induce an increase in platelet counts, indicating autodesensitization. Desensitization to PAP or pretreatment with PAP antagonists clearly prevented the increase in the platelet counts after stimulation by adrenaline (15 μg/kg). These findings suggest that, in rats, PAP can induce release of platelets by a spleen-dependent mechanism and that this lipid may be relevant to the thrombocytosis triggered by adrenaline.

PRMT1-Orchestrated Fibroblast Activation in Renal Fibrosis Induced by TGFß/Smad3 Signaling Pathway

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2197-PUB
Author(s):  
YU ZHU ◽  
Keyword(s):  
Signaling Pathway ◽  
Renal Fibrosis ◽  
Fibroblast Activation
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