scholarly journals A sensitive and cost‐effective high‐performance liquid chromatography/tandem mass spectrometry (multiple reaction monitoring) method for the clinical measurement of serum hepcidin

2020 ◽  
Vol 34 (S1) ◽  
Author(s):  
Michael Chen ◽  
Jun Liu ◽  
Bruce Wright
Keyword(s):  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Cost Effective ◽  
Tandem Mass ◽  
Reaction Monitoring ◽  
Monitoring Method ◽  
Clinical Measurement ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Serum Hepcidin

Development of a multiple reaction monitoring (MRM) method based on high performance liquid chromatography/tandem mass spectrometry to analyze in vivo exposure profiles of complex herbal components independent of standards

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19357-19371
Author(s):  
Tong Xie ◽  
An Kang ◽  
Jianya Xu ◽  
Cunsi Shen ◽  
Xia Zhao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Tandem Mass ◽  
Reaction Monitoring ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Herbal Components ◽  
Pharmacokinetic Evaluation

Exposure profiles of herbal componentsin vivoplay pivotal roles in pharmacodynamic and pharmacokinetic evaluation. The proposed MRM method has enabled profile exposure components, time and relative levels accurately.

Residue Analysis of Benzobicyclon in Soil and Sediment Samples by Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry

2016 ◽  
Vol 99 (6) ◽  
pp. 1628-1635 ◽  
Author(s):  
Qianqian Sun ◽  
Yihu Wang ◽  
Chunxia Tian ◽  
Wenjun Gui ◽  
Yirong Guo ◽  
...  
Keyword(s):  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Residue Analysis ◽  
Environmental Safety ◽  
Reaction Monitoring ◽  
Sediment Samples ◽  
Chromatography Tandem Mass Spectrometry ◽  
Sample Test ◽  
Liquid Chromatography Tandem Mass ◽  
Soil And Sediment

Abstract A reliable and rapid method was developed to determine benzobicyclon residue in different soil and sediment samples. After extraction via a modified quick, easy, cheap, effective, rugged, and safe method, samples were purified by SPE cleanup with HLB cartridges. Quantitative determination was performed by ultra-HPLC (UPLC)-tandem MS (MS/MS) in electrospray positive ionization and multiple reaction monitoring modes. When samples were fortified at concentrations of 5, 50, and 500 µg/L, recoveries of 80.2 to 114.5% were obtained, with the repeatability (intraday RSDr) and reproducibility (interday RSDR) <14.1 and <21.4%, respectively. The instrumental LODs and LOQs for matrix-matched standards and the method LOQs for sample test were 0.19–1.34 μg/L, 0.64–4.48 μg/L, and 0.32–2.24 μg/kg, respectively. The linear range was 5–1000 μg/L (R2 > 0.99). The established UPLC-MS/MS method was applied in the detection of benzobicyclon in real soil samples, which were collected during the supervised field trial. Results showed that the maximum concentration of benzobicyclon in the soil was 4.87 mg/kg and its degradation half-life (t0.5) was 6.7 days. Generally, the proposed method could be an effective tool for controlling and monitoring the risks posed by benzobicyclon to human health and environmental safety.

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