Multiple reaction monitoring-based determination of bovine α-lactalbumin in infant formulas and whey protein concentrates by ultra-high performance liquid chromatography–tandem mass spectrometry using tryptic signature peptides and synthetic peptide standards

2012 ◽  
Vol 727 ◽  
pp. 47-53 ◽  
Author(s):  
Jingshun Zhang ◽  
Shiyun Lai ◽  
Yu Zhang ◽  
Baifen Huang ◽  
Duo Li ◽  
...  
Keyword(s):  
Synthetic Peptide ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Tandem Mass ◽  
Reaction Monitoring ◽  
Whey Protein Concentrates ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Signature Peptides

Development of a multiple reaction monitoring (MRM) method based on high performance liquid chromatography/tandem mass spectrometry to analyze in vivo exposure profiles of complex herbal components independent of standards

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19357-19371
Author(s):  
Tong Xie ◽  
An Kang ◽  
Jianya Xu ◽  
Cunsi Shen ◽  
Xia Zhao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Tandem Mass ◽  
Reaction Monitoring ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Herbal Components ◽  
Pharmacokinetic Evaluation

Exposure profiles of herbal componentsin vivoplay pivotal roles in pharmacodynamic and pharmacokinetic evaluation. The proposed MRM method has enabled profile exposure components, time and relative levels accurately.

Simultaneous determination of entecavir and lamivudine in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study

RSC Advances ◽  
2016 ◽  
Vol 6 (75) ◽  
pp. 70990-70998 ◽  
Author(s):  
Qikun Jiang ◽  
Yan Liu ◽  
Yunjie Wang ◽  
Yinghua Sun ◽  
Bo Li ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Multiple Reaction Monitoring ◽  
Ultra Performance Liquid Chromatography ◽  
Rat Plasma ◽  
Tandem Mass ◽  
Reaction Monitoring ◽  
Chromatography Tandem Mass Spectrometry ◽  
Mode Method ◽  
Liquid Chromatography Tandem Mass

The study's aim is to develop and validate a rapid, selective and sensitive ultra-performance liquid chromatography-tandem mass spectrometry with multiple reaction monitoring (MRM) mode method for the simultaneous determination of entecavir and lamivudine in rat plasma.

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