Epidemiology and management of chronic hepatitis E infection in solid organ transplantation: a comprehensive literature review

2013 ◽  
Vol 23 (5) ◽  
pp. 295-304 ◽  
Author(s):  
Xinying Zhou ◽  
Robert A. de Man ◽  
Robert J. de Knegt ◽  
Herold J. Metselaar ◽  
Maikel P. Peppelenbosch ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Literature Review ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Hepatitis E ◽  
Solid Organ ◽  
Comprehensive Literature Review

P704 CLINICAL COURSE AND TREATMENT OF CHRONIC HEPATITIS E INFECTION IN PATIENTS AFTER SOLID ORGAN TRANSPLANTATION

2014 ◽  
Vol 60 (1) ◽  
pp. S303-S304
Author(s):  
E. Halilbasic ◽  
L. Kazemi-Shirazi ◽  
K. Staufer ◽  
P. Munda ◽  
C.J. Müller ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Organ Transplantation ◽  
Clinical Course ◽  
Solid Organ Transplantation ◽  
Hepatitis E ◽  
Solid Organ

Chronic hepatitis E in solid-organ transplantation

2014 ◽  
Vol 27 (4) ◽  
pp. 303-308 ◽  
Author(s):  
Yijin Wang ◽  
Herold J. Metselaar ◽  
Maikel P. Peppelenbosch ◽  
Qiuwei Pan
Keyword(s):  
Chronic Hepatitis ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Hepatitis E ◽  
Solid Organ

scholarly journals Case Report: Paracoccidioidomycosis in Solid Organ Transplantation: Disseminated Disease in a Liver Recipient and Literature Review

2019 ◽  
Vol 101 (5) ◽  
pp. 1100-1106
Author(s):  
Paula M. Peçanha-Pietrobom ◽  
Aloisio Falqueto ◽  
Anna Danielle Rodrigues Gandarella ◽  
Júlia Vieira Moyzés ◽  
Karoline Almeida Rangel ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Disseminated Disease ◽  
Liver Recipient

Prevention of cytomegalovirus following solid organ transplantation: A literature review

2013 ◽  
Vol 17 (6) ◽  
pp. 499-509 ◽  
Author(s):  
Shanna Kowalsky ◽  
Ronen Arnon ◽  
Roberto Posada
Keyword(s):  
Literature Review ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Solid Organ

Are recipients of solid organ transplantation a high-risk population for hepatitis E virus infection?

2009 ◽  
Vol 16 (1) ◽  
pp. 106-107 ◽  
Author(s):  
Maria Buti ◽  
Cecilia Cabrera ◽  
Rosendo Jardi ◽  
Luis Castells ◽  
Rafael Esteban
Keyword(s):  
High Risk ◽  
Virus Infection ◽  
Organ Transplantation ◽  
Hepatitis E Virus ◽  
Solid Organ Transplantation ◽  
Hepatitis E ◽  
High Risk Population ◽  
Solid Organ ◽  
Risk Population

scholarly journals Rituximab-Containing Treatment Regimens May Imply a Long-Term Risk for Difficult-To-Treat Chronic Hepatitis E

2020 ◽  
Vol 17 (1) ◽  
pp. 341 ◽  
Author(s):  
Marten Schulz ◽  
Paula Biedermann ◽  
Claus-Thomas Bock ◽  
Jörg Hofmann ◽  
Mira Choi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Treatment Failure ◽  
Mutational Analysis ◽  
Solid Organ Transplantation ◽  
Hepatitis E ◽  
Solid Organ ◽  
Industrialized Countries ◽  
Treatment Regimens ◽  
Increased Risk ◽  
T Cell Lymphopenia

Hepatitis E virus (HEV) infection is an emerging disease in industrialized countries which is usually characterized by a self-limited course. However, there is an increased risk of HEV persistence in immunocompromised risk populations, comprising patients following solid organ transplantation or hematological malignancies. Recently, chronic HEV infection following rituximab-containing treatment regimens has been described. Here we report five patients with chronic hepatitis E after prior rituximab therapy for various indications. We determined the immunological characteristics of these patients and analyzed the development of ribavirin (RBV) treatment failure-associated mutations in the HEV genome. One patient became chronically HEV-infected 110 months after administration of rituximab (RTX). Immunological characterization revealed that all patients exhibited significant hypogammaglobulinemia and CD4+ T cell lymphopenia. One patient permanently cleared HEV following weight-based ribavirin treatment while three patients failed to reach a sustained virological response. In depth mutational analysis confirmed the presence of specific mutations associated with RBV treatment failure in these patients. Our cases indicate that rituximab-containing treatment regimens might imply a relevant risk for persistent HEV infection even years after the last rituximab application. Moreover, we provide further evidence to prior observations suggesting that chronically HEV infected patients following RTX-containing treatment regimens might be difficult to treat.

Summary of the British Transplantation Society UK Guidelines for Hepatitis E and Solid Organ Transplantation

2018 ◽  
Vol 102 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Stuart McPherson ◽  
Ahmed M. Elsharkawy ◽  
Michael Ankcorn ◽  
Samreen Ijaz ◽  
James Powell ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Hepatitis E ◽  
Solid Organ ◽  
Transplantation Society
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