A Spheroid‐Forming Hybrid Gold Nanostructure Platform That Electrochemically Detects Anticancer Effects of Curcumin in a Multicellular Brain Cancer Model

Abstract Among children/infant brain tumors, Medulloblastoma (MB) is the most common and stands as a cause for a high percentage of morbidity and mortality among patients During the past few years, studies on human MB have uncovered the existence of four major MB groups: WNT, SHH, Group3 and Group4. Patients with Group3 MB currently have the worst outcome among the four groups, and nearly 50% are metastatic at the time of diagnosis. In the last 3 years in our laboratory, we have developed a novel pediatric Medulloblastoma organoid model. We generated human iPSC-derived cancer organoids upon c-MYC/OTX2 and C-MYC/Gfi1 overexpression, mimicking human MB genetic alterations. Furthermore, the use of DNA methylation signature in combination with MB-specific markers analysis indicates that our organoid-based cancer model recapitulates several features of human MB. Now, we are taking advantage of this technology to produce novel brain cancer organoids that we are using to address cancer biology questions.

Download Full-text

Abstract 4175: Anticancer effects of heparin in the experimental metastasis of the pancreatic cancer model with enhanced potency of gemcitabine

10.1158/1538-7445.am10-4175 ◽

2010 ◽

Author(s):

Noriyuki Tani ◽

Koichi Aiura ◽

Keiichi Suzuki ◽

Sachiko Matsuda ◽

Masakazu Ueda ◽

...

Keyword(s):

Pancreatic Cancer ◽

Experimental Metastasis ◽

Cancer Model ◽

Anticancer Effects

Download Full-text

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

Biomolecules ◽

10.3390/biom10010161 ◽

2020 ◽

Vol 10 (1) ◽

pp. 161 ◽

Cited By ~ 11

Author(s):

Terezia Kiskova ◽

Peter Kubatka ◽

Dietrich Büsselberg ◽

Monika Kassayova

Keyword(s):

Brain Cancer ◽

Standard Treatment ◽

Alkylating Agents ◽

Malignant Gliomas ◽

In Vivo Studies ◽

Anticancer Effects ◽

The Central Nervous System ◽

Methylguanine Methyltransferase

Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood‒brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clinical research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.

Download Full-text

Alterations in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated withα-Mangostin Extracted from Mangosteen Pericarp

Journal of Biomedicine and Biotechnology ◽

10.1155/2012/672428 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 29

Author(s):

Hitomi Kurose ◽

Masa-Aki Shibata ◽

Munekazu Iinuma ◽

Yoshinori Otsuki

Keyword(s):

Breast Cancer ◽

Cell Cycle ◽

Cancer Cell ◽

Apoptotic Cell ◽

Cancer Cell Line ◽

P53 Mutation ◽

Cancer Model ◽

Anticancer Effects ◽

G1 Phase Arrest ◽

Mammary Cancer Model

The development of molecularly targeted drugs has greatly advanced cancer therapy, despite these drugs being associated with some serious problems. Recently, increasing attention has been paid to the anticancer effects of natural products.α-Mangostin, a xanthone isolated from the pericarp of mangosteen fruit, has been shown to induce apoptosis in various cancer cell lines and to exhibit antitumor activity in a mouse mammary cancer model. In this study, we investigated the influence ofα-mangostin on apoptosis and cell cycle in the human breast cancer cell line MDA-MB231 (carrying a p53 mutation, and HER2, ER, and PgR negative) in order to elucidate its anticancer mechanisms. Inα-mangostin-treated cells, induction of mitochondria-mediated apoptosis was observed. On cell-cycle analysis, G1-phase arrest, increasedp21cip1expression and decreases in cyclins, cdc(s), CDKs and PCNA were observed. In conclusion,α-mangostin may be useful as a therapeutic agent for breast cancer carrying a p53 mutation and having HER2- and hormone receptor-negative subtypes.

Download Full-text