Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury

Small ◽  
2021 ◽  
Vol 17 (8) ◽  
pp. 2005113
Author(s):  
Dong‐Yang Zhang ◽  
Hengke Liu ◽  
Ting He ◽  
Muhammad Rizwan Younis ◽  
Tianhui Tu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Nitrogen Species ◽  
Self Assembled

scholarly journals Biodegradable Nanodots: Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury (Small 8/2021)

Small ◽  
2021 ◽  
Vol 17 (8) ◽  
pp. 2170033
Author(s):  
Dong‐Yang Zhang ◽  
Hengke Liu ◽  
Ting He ◽  
Muhammad Rizwan Younis ◽  
Tianhui Tu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Nitrogen Species ◽  
Self Assembled

Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management

Biomaterials ◽  
2021 ◽  
Vol 271 ◽  
pp. 120706 ◽  
Author(s):  
Dong-Yang Zhang ◽  
Muhammad Rizwan Younis ◽  
Hengke Liu ◽  
Shan Lei ◽  
Yilin Wan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Nitrogen Species ◽  
Enzyme Mimetic ◽  
Injury Management

scholarly journals Reactive oxygen species and acute kidney injury after trauma in obese rats (859.2)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Peter Mittwede ◽  
Lusha Xiang ◽  
Silu Lu ◽  
John Clemmer ◽  
Robert Hester
Keyword(s):  
Reactive Oxygen Species ◽  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Oxygen Species ◽  
Obese Rats

scholarly journals Exogenous pentraxin-3 inhibits the reactive oxygen species-mitochondrial and apoptosis pathway in acute kidney injury

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195758 ◽  
Author(s):  
Hyung Ho Lee ◽  
Sook Young Kim ◽  
Joon Chae Na ◽  
Young Eun Yoon ◽  
Woong Kyu Han
Keyword(s):  
Reactive Oxygen Species ◽  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Oxygen Species ◽  
Pentraxin 3 ◽  
Apoptosis Pathway

scholarly journals Treatment of Acute Kidney Injury Using a Dual Enzyme Embedded Zeolitic Imidazolate Frameworks Cascade That Catalyzes In Vivo Reactive Oxygen Species Scavenging

2022 ◽  
Vol 9 ◽  
Author(s):  
Xinyue Hou ◽  
Jianxiang Shi ◽  
Jie Zhang ◽  
Zhigang Wang ◽  
Sen Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Acute Kidney Injury ◽  
Effective Means ◽  
Antioxidant Properties ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Oxygen Species ◽  
Zeolitic Imidazolate Frameworks ◽  
Zeolitic Imidazolate Framework ◽  
Intracellular Enzyme

Significant advances have been made in recent years for the utilization of natural enzymes with antioxidant properties to treat acute kidney injury (AKI). However, these enzymes have been of limited clinical utility because of their limited cellular uptake, poor pharmacokinetic properties, and suboptimal stability. We employed a novel biomimetic mineralization approach to encapsulate catalase (CAT) and superoxide dismutase (SOD) in a zeolitic imidazolate framework-8 (ZIF-8). Next, this SOD@CAT@ZIF-8 complex was anchored with MPEG2000-COOH to yield an MPEG2000-SOD@CAT@ZIF-8 (PSCZ) composite. The composite was then used as a stable tool with antioxidant properties for the integrated cascade-based treatment of AKI, remarkably improved intracellular enzyme delivery. This dual-enzyme-embedded metal-organic framework could effectively scavenge reactive oxygen species. In conclusion, the ZIF-8-based “armor plating” represents an effective means of shielding enzymes with improved therapeutic utility to guide the precision medicine-based treatment of AKI.

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