Reactive Oxygen and Nitrogen Species, Oxidative and Nitrosative Stress, and Their Role in the Pathogenesis of Acute Kidney Injury

2010 ◽  
pp. 161-177 ◽  
Author(s):  
Eisei Noiri ◽  
Francesco Addabbo ◽  
Michael S. Goligorsky
Keyword(s):  
Acute Kidney Injury ◽  
Nitrosative Stress ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Nitrogen Species ◽  
Oxidative And Nitrosative Stress

Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury

Small ◽  
2021 ◽  
Vol 17 (8) ◽  
pp. 2005113
Author(s):  
Dong‐Yang Zhang ◽  
Hengke Liu ◽  
Ting He ◽  
Muhammad Rizwan Younis ◽  
Tianhui Tu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Nitrogen Species ◽  
Self Assembled

Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management

Biomaterials ◽  
2021 ◽  
Vol 271 ◽  
pp. 120706 ◽  
Author(s):  
Dong-Yang Zhang ◽  
Muhammad Rizwan Younis ◽  
Hengke Liu ◽  
Shan Lei ◽  
Yilin Wan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Nitrogen Species ◽  
Enzyme Mimetic ◽  
Injury Management

scholarly journals Biodegradable Nanodots: Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury (Small 8/2021)

Small ◽  
2021 ◽  
Vol 17 (8) ◽  
pp. 2170033
Author(s):  
Dong‐Yang Zhang ◽  
Hengke Liu ◽  
Ting He ◽  
Muhammad Rizwan Younis ◽  
Tianhui Tu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Nitrogen Species ◽  
Self Assembled

scholarly journals Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber’s Hereditary Optic Neuropathy Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Micol Falabella ◽  
Elena Forte ◽  
Maria Chiara Magnifico ◽  
Paolo Santini ◽  
Marzia Arese ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Optic Neuropathy ◽  
Nitrosative Stress ◽  
Mononuclear Cells ◽  
Reactive Oxygen ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy

Here we have collected evidence suggesting that chronic changes in the NO homeostasis and the rise of reactive oxygen species bioavailability can contribute to cell dysfunction in Leber’s hereditary optic neuropathy (LHON) patients. We report that peripheral blood mononuclear cells (PBMCs), derived from a female LHON patient with bilateral reduced vision and carrying the pathogenic mutation 11778/ND4, display increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as revealed by flow cytometry, fluorometric measurements of nitrite/nitrate, and 3-nitrotyrosine immunodetection. Moreover, viability assays with the tetrazolium dye MTT showed that lymphoblasts from the same patient are more sensitive to prolonged NO exposure, leading to cell death. Taken together these findings suggest that oxidative and nitrosative stress cooperatively play an important role in driving LHON pathology when excess NO remains available over time in the cell environment.

New evidence for vascular interactions between aldosterone, angiotensin II and antioxidants in isolated smooth muscle cells of rats

Open Medicine ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. 704-712
Author(s):  
Raducu Popescu ◽  
Walther Bild ◽  
Alin Ciobica ◽  
Veronica Bild
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Nitrosative Stress ◽  
Reactive Oxygen ◽  
Muscle Cells ◽  
No Production ◽  
Nitrogen Species ◽  
First Case

AbstractAccumulating evidence suggests that the nongenomic cardiovascular actions of aldosterone are produced by varied cellular pathways and mediated by a multitude of messenger systems including the reactive oxygen and nitrogen species. Considering the involvement of the oxidative and nitrosative stress in the pathways leading to the activation of the angiotensin — aldosterone system, in the current study we tried to evaluate the functional interactions between aldosterone, angiotensin II and antioxidants in isolated vascular smooth muscle of aortic rings from rats. Our data provide additional arguments that the nongenomic actions of aldosterone on aortic smooth muscle cells of rats are a question of cross-talk and balance between its rapid vasoconstrictor and vasodilator effects, as result of the activation of reactive oxygen species in the first case and of nitrogen species in the second. In this way, it seems that at low ambient oxidative stress, aldosterone promotes nitric oxide (NO) production and vasodilatation, while in situations with increased oxidative stress the endothelial dysfunction and detrimental effects induced by vasoconstriction will prevail. Thus, aldosterone could be considered both “friend and foe”. This could be relevant for the ways in which aldosterone damages cardiovascular functions and could lead to significant therapeutic improvements.

Effect of combined oxidative and nitrosative stress on Neisseria meningitidis

2006 ◽  
Vol 34 (1) ◽  
pp. 197-199 ◽  
Author(s):  
K. Dyet ◽  
J. Moir
Keyword(s):  
Neisseria Meningitidis ◽  
Nitrosative Stress ◽  
Aetiological Agent ◽  
Nitrogen Species ◽  
Enteric Bacterium ◽  
Human Pathogens ◽  
Human Immune System ◽  
Oxidative And Nitrosative Stress ◽  
No Donor ◽  
Human Immune

Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O2−), hydrogen peroxide (H2O2) and nitric oxide (NO). The toxicity of O2−, generated using X/Xo (xanthine/xanthine oxidase), and H2O2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-(N,N-diethylamino)-diazenolate-2-oxide diethylammonium salt]. Most of the toxicity from X/Xo was due to H2O2. In N. meningitidis, NO decreased the toxicity of the H2O2. In contrast, in the enteric bacterium Escherichia coli, NO increased the toxicity of the H2O2.

scholarly journals Reactive oxygen species and acute kidney injury after trauma in obese rats (859.2)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Peter Mittwede ◽  
Lusha Xiang ◽  
Silu Lu ◽  
John Clemmer ◽  
Robert Hester
Keyword(s):  
Reactive Oxygen Species ◽  
Acute Kidney Injury ◽  
Reactive Oxygen ◽  
Kidney Injury ◽  
Oxygen Species ◽  
Obese Rats
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