Simple and rapid analysis of Linagliptin in dried blood spot using an ionic liquid based vortex‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatography–electrospray ionization–tandem mass spectrometry: Application to pharmacokinetic studies

2021 ◽  
Author(s):  
Manikanta Swamy Arnipalli ◽  
Narendra Varma Nimmu ◽  
Ramachandra Bondigalla ◽  
Gangu Naidu Challa
Keyword(s):  
Mass Spectrometry ◽  
Ionic Liquid ◽  
Rapid Analysis ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction ◽  
Mass Spectrometry Application ◽  
Blood Spot ◽  
Ionization Tandem Mass Spectrometry

Determination of UV-327 and its metabolites in human urine using dispersive liquid-liquid microextraction and gas chromatography-tandem mass spectrometry

2021 ◽  
Vol 13 (35) ◽  
pp. 3978-3986
Author(s):  
Corinna Fischer ◽  
Thomas Göen
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Tandem Mass Spectrometry ◽  
Human Urine ◽  
Tandem Mass ◽  
Extraction Solvent ◽  
Chromatography Tandem Mass Spectrometry ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

A method is presented for the extraction of the UV stabilizer UV-327 and its metabolites from urine with acetonitrile (disperser solvent) and chloroform (extraction solvent), followed by instrumental analysis of the trimethylsilylated analytes.

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