scholarly journals Barx2 and Pax7 Have Antagonistic Functions in Regulation of Wnt Signaling and Satellite Cell Differentiation

Stem Cells ◽  
2014 ◽  
Vol 32 (6) ◽  
pp. 1661-1673 ◽  
Author(s):  
Lizhe Zhuang ◽  
Julie-Ann Hulin ◽  
Anastasia Gromova ◽  
Thi Diem Tran Nguyen ◽  
Ruth T. Yu ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Wnt Signaling ◽  
Satellite Cell

A serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation

Nature Food ◽  
2022 ◽  
Author(s):  
Tobias Messmer ◽  
Iva Klevernic ◽  
Carolina Furquim ◽  
Ekaterina Ovchinnikova ◽  
Arin Dogan ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Satellite Cell ◽  
Serum Starvation ◽  
Meat Production ◽  
Serum Free ◽  
Media Formulation ◽  
Cultured Meat ◽  
Free Media

Pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model for satellite cell differentiation and renewal

2004 ◽  
Vol 231 (3) ◽  
pp. 489-502 ◽  
Author(s):  
Orna Halevy ◽  
Yogev Piestun ◽  
Mohammed Z. Allouh ◽  
Benjamin W.C. Rosser ◽  
Yuval Rinkevich ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Satellite Cell

scholarly journals Effects of intramuscular administration of 1α,25(OH)2D3 during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis

2016 ◽  
Vol 120 (12) ◽  
pp. 1381-1393 ◽  
Author(s):  
Ratchakrit Srikuea ◽  
Muthita Hirunsai
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Protein Synthesis ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Muscle Regeneration ◽  
Fiber Type ◽  
Fiber Formation ◽  
Skeletal Muscle Regeneration ◽  
Type Composition

The recent discovery of the vitamin D receptor (VDR) in regenerating muscle raises the question regarding the action of vitamin D3 on skeletal muscle regeneration. To investigate the action of vitamin D3 on this process, the tibialis anterior muscle of male C57BL/6 mice (10 wk of age) was injected with 1.2% BaCl2 to induce extensive muscle injury. The bioactive form of vitamin D3 [1α,25(OH)2D3] was administered daily via intramuscular injections during the regenerative phase (days 4-7 postinjury). Physiological and supraphysiological doses of 1α,25(OH)2D3 relative to 1 μg/kg muscle wet weight and mouse body weight were investigated. Muscle samples were collected on day 8 postinjury to examine proteins related to vitamin D3 metabolism (VDR, CYP24A1, and CYP27B1), satellite cell differentiation and regenerative muscle fiber formation [myogenin and embryonic myosin heavy chain (EbMHC)], protein synthesis signaling (Akt, p70 S6K1, 4E-BP1, and myostatin), fiber-type composition (fast and slow MHCs), fibrous formation (vimentin), and angiogenesis (CD31). Administration of 1α,25(OH)2D3 at physiological and supraphysiological doses enhanced VDR expression in regenerative muscle. Moreover, CYP24A1 and vimentin expression was increased, accompanying decreased myogenin and EbMHC expression at the supraphysiological dose. However, there was no change in CYP27B1, Akt, p70 S6K1, 4E-BP1, myostatin, fast and slow MHCs, or CD31 expression at any dose investigated. Taken together, administration of 1α,25(OH)2D3 at a supraphysiological dose decreased satellite cell differentiation, delayed regenerative muscle fiber formation, and increased muscular fibrosis. However, protein synthesis signaling, fiber-type composition, and angiogenesis were not affected by either 1α,25(OH)2D3 administration at a physiological or supraphysiological dose.

scholarly journals Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung

2016 ◽  
Vol 414 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Xiaoru Wang ◽  
Yi Wang ◽  
Melinda E. Snitow ◽  
Kathleen M. Stewart ◽  
Shanru Li ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Wnt Signaling ◽  
Histone Deacetylase ◽  
Alveolar Type ◽  
Type I ◽  
Histone Deacetylase 3 ◽  
Alveolar Type I Cell

Effect ofECM2expression on bovine skeletal muscle-derived satellite cell differentiation

2018 ◽  
Vol 42 (5) ◽  
pp. 525-532 ◽  
Author(s):  
Chang Liu ◽  
Huili Tong ◽  
Shufeng Li ◽  
Yunqin Yan
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Bovine Skeletal Muscle

scholarly journals Wnt signaling in kidney: the initiator or terminator?

2020 ◽  
Vol 98 (11) ◽  
pp. 1511-1523 ◽  
Author(s):  
Ping Meng ◽  
Mingsheng Zhu ◽  
Xian Ling ◽  
Lili Zhou
Keyword(s):  
Cell Differentiation ◽  
Embryonic Development ◽  
Wnt Signaling ◽  
Tissue Repair ◽  
Progenitor Cell ◽  
Kidney Development ◽  
Kidney Diseases ◽  
Electrolyte Balance ◽  
Tissue Repair And Regeneration

Abstract The kidney is a key organ in the human body that excretes toxins and sustains the water–electrolyte balance. During embryonic development and disease progression, the kidney undergoes enormous changes in macrostructure, accompanied by a variety of microstructural histological changes, such as glomerular formation and sclerosis, tubule elongation and atrophy, interstitial establishment, and fibrosis progression. All of these rely on the frequent occurrence of cell death and growth. Notably, to overcome disease, some cells regenerate through self-repair or progenitor cell differentiation. However, the signaling mechanisms underlying kidney development and regeneration have not been elucidated. Recently, Wnt signaling has been noted to play an important role. Although it is a well-known developmental signal, the role of Wnt signaling in kidney development and regeneration is not well recognized. In this review, we review the role of Wnt signaling in kidney embryonic development, tissue repair, cell division, and progenitor cell differentiation after injury. Moreover, we briefly highlight advances in our understanding of the pathogenic mechanisms of Wnt signaling in mediating cellular senescence in kidney parenchymal and stem cells, an irreversible arrest of cell proliferation blocking tissue repair and regeneration. We also highlight the therapeutic targets of Wnt signaling in kidney diseases and provide important clues for clinical strategies.

scholarly journals Atypical Protein Kinase Cs Are the Ras Effectors That Mediate Repression of Myogenic Satellite Cell Differentiation

2002 ◽  
Vol 22 (4) ◽  
pp. 1140-1149 ◽  
Author(s):  
Yuri V. Fedorov ◽  
Nathan C. Jones ◽  
Bradley B. Olwin
Keyword(s):  
Skeletal Muscle ◽  
Cell Proliferation ◽  
Cell Differentiation ◽  
Cell Line ◽  
Satellite Cell ◽  
Myogenic Differentiation ◽  
Ectopic Expression ◽  
Dominant Negative ◽  
Dependent Inhibition ◽  
Ras Effectors

ABSTRACT Oncogenic Ha-Ras is a potent inhibitor of skeletal muscle cell differentiation, yet the Ras effector mediating this process remains unidentified. Here we demonstrate that the atypical protein kinases (aPKCs; λ and/or ζ) are downstream Ras effectors responsible for Ras-dependent inhibition of myogenic differentiation in a satellite cell line. First, ectopic expression of Ha-RasG12V induces translocation of PKCλ from the cytosol to the nucleus, suggesting that aPKCs are activated by Ras in myoblasts. The aPKCs function as downstream Ras effectors since inhibition of aPKCs by expression of a dominant negative PKCζ mutant or by treatment of cells with an inhibitor, GO6983, promotes myogenesis in skeletal muscle satellite cells expressing oncogenic Ha-Ras. Arresting cell proliferation synergistically enhances myogenic differentiation only when aPKCs are also inhibited. Thus, the repression of myogenic differentiation in a satellite cell line appears to be directly mediated by aPKCs acting as Ras effectors and indirectly mediated via stimulation of cell proliferation.

Wnt signaling in neuroprotection and stem cell differentiation

2008 ◽  
Vol 86 (3) ◽  
pp. 281-296 ◽  
Author(s):  
Enrique M. Toledo ◽  
Marcela Colombres ◽  
Nibaldo C. Inestrosa
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Wnt Signaling ◽  
Stem Cell Differentiation
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