Effect ofECM2expression on bovine skeletal muscle-derived satellite cell differentiation

2018 ◽  
Vol 42 (5) ◽  
pp. 525-532 ◽  
Author(s):  
Chang Liu ◽  
Huili Tong ◽  
Shufeng Li ◽  
Yunqin Yan
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Bovine Skeletal Muscle

Fatty acids promote bovine skeletal muscle satellite cell differentiation by regulating ELOVL3 expression

2018 ◽  
Vol 373 (2) ◽  
pp. 499-508 ◽  
Author(s):  
Jiahui Xu ◽  
Dan Liu ◽  
Hongyan Yin ◽  
Huili Tong ◽  
Shufeng Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Muscle Satellite Cell ◽  
Skeletal Muscle Satellite Cell ◽  
Bovine Skeletal Muscle

Effect of ELOVL3 expression on bovine skeletal muscle-derived satellite cell differentiation

2017 ◽  
Vol 493 (4) ◽  
pp. 1457-1463
Author(s):  
Dan Liu ◽  
Jia-Hui Xu ◽  
Hui-Li Tong ◽  
Shu-Feng Li ◽  
Yun-Qin Yan
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Bovine Skeletal Muscle

scholarly journals Effects of intramuscular administration of 1α,25(OH)2D3 during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis

2016 ◽  
Vol 120 (12) ◽  
pp. 1381-1393 ◽  
Author(s):  
Ratchakrit Srikuea ◽  
Muthita Hirunsai
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Protein Synthesis ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Muscle Regeneration ◽  
Fiber Type ◽  
Fiber Formation ◽  
Skeletal Muscle Regeneration ◽  
Type Composition

The recent discovery of the vitamin D receptor (VDR) in regenerating muscle raises the question regarding the action of vitamin D3 on skeletal muscle regeneration. To investigate the action of vitamin D3 on this process, the tibialis anterior muscle of male C57BL/6 mice (10 wk of age) was injected with 1.2% BaCl2 to induce extensive muscle injury. The bioactive form of vitamin D3 [1α,25(OH)2D3] was administered daily via intramuscular injections during the regenerative phase (days 4-7 postinjury). Physiological and supraphysiological doses of 1α,25(OH)2D3 relative to 1 μg/kg muscle wet weight and mouse body weight were investigated. Muscle samples were collected on day 8 postinjury to examine proteins related to vitamin D3 metabolism (VDR, CYP24A1, and CYP27B1), satellite cell differentiation and regenerative muscle fiber formation [myogenin and embryonic myosin heavy chain (EbMHC)], protein synthesis signaling (Akt, p70 S6K1, 4E-BP1, and myostatin), fiber-type composition (fast and slow MHCs), fibrous formation (vimentin), and angiogenesis (CD31). Administration of 1α,25(OH)2D3 at physiological and supraphysiological doses enhanced VDR expression in regenerative muscle. Moreover, CYP24A1 and vimentin expression was increased, accompanying decreased myogenin and EbMHC expression at the supraphysiological dose. However, there was no change in CYP27B1, Akt, p70 S6K1, 4E-BP1, myostatin, fast and slow MHCs, or CD31 expression at any dose investigated. Taken together, administration of 1α,25(OH)2D3 at a supraphysiological dose decreased satellite cell differentiation, delayed regenerative muscle fiber formation, and increased muscular fibrosis. However, protein synthesis signaling, fiber-type composition, and angiogenesis were not affected by either 1α,25(OH)2D3 administration at a physiological or supraphysiological dose.

TCP11L2 promotes bovine skeletal muscle‐derived satellite cell migration and differentiation via FMNL2

2020 ◽  
Vol 235 (10) ◽  
pp. 7183-7193
Author(s):  
Shuang Li ◽  
Zhiqi Wang ◽  
Huili Tong ◽  
Shufeng Li ◽  
Yunqin Yan
Keyword(s):  
Skeletal Muscle ◽  
Cell Migration ◽  
Satellite Cell ◽  
Bovine Skeletal Muscle

scholarly journals Atypical Protein Kinase Cs Are the Ras Effectors That Mediate Repression of Myogenic Satellite Cell Differentiation

2002 ◽  
Vol 22 (4) ◽  
pp. 1140-1149 ◽  
Author(s):  
Yuri V. Fedorov ◽  
Nathan C. Jones ◽  
Bradley B. Olwin
Keyword(s):  
Skeletal Muscle ◽  
Cell Proliferation ◽  
Cell Differentiation ◽  
Cell Line ◽  
Satellite Cell ◽  
Myogenic Differentiation ◽  
Ectopic Expression ◽  
Dominant Negative ◽  
Dependent Inhibition ◽  
Ras Effectors

ABSTRACT Oncogenic Ha-Ras is a potent inhibitor of skeletal muscle cell differentiation, yet the Ras effector mediating this process remains unidentified. Here we demonstrate that the atypical protein kinases (aPKCs; λ and/or ζ) are downstream Ras effectors responsible for Ras-dependent inhibition of myogenic differentiation in a satellite cell line. First, ectopic expression of Ha-RasG12V induces translocation of PKCλ from the cytosol to the nucleus, suggesting that aPKCs are activated by Ras in myoblasts. The aPKCs function as downstream Ras effectors since inhibition of aPKCs by expression of a dominant negative PKCζ mutant or by treatment of cells with an inhibitor, GO6983, promotes myogenesis in skeletal muscle satellite cells expressing oncogenic Ha-Ras. Arresting cell proliferation synergistically enhances myogenic differentiation only when aPKCs are also inhibited. Thus, the repression of myogenic differentiation in a satellite cell line appears to be directly mediated by aPKCs acting as Ras effectors and indirectly mediated via stimulation of cell proliferation.

scholarly journals Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration

2018 ◽  
Vol 32 (3) ◽  
pp. 1452-1467 ◽  
Author(s):  
Yukino Hatazawa ◽  
Yusuke Ono ◽  
Yuma Hirose ◽  
Sayaka Kanai ◽  
Nobuharu L. Fujii ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration

scholarly journals MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration

2012 ◽  
Vol 26 (2) ◽  
pp. 190-202 ◽  
Author(s):  
M. H. Mokalled ◽  
A. N. Johnson ◽  
E. E. Creemers ◽  
E. N. Olson
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Satellite Cell ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration
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