scholarly journals Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells

2008 ◽  
Vol 2 (8) ◽  
pp. 491-498 ◽  
Author(s):  
Ellen P. Brennan ◽  
Xiao-Han Tang ◽  
Ann M. Stewart-Akers ◽  
Lorraine J. Gudas ◽  
Stephen F. Badylak
Keyword(s):  
Extracellular Matrix ◽  
Progenitor Cells ◽  
Degradation Products ◽  
Adult Skin

A Robustly Supported Extracellular Matrix Improves the Intravascular Delivery Efficacy of Endothelial Progenitor Cells

2021 ◽  
pp. 2100324
Author(s):  
Chungwon Park ◽  
Kwang‐Sook Park ◽  
Mi Jin Jeong ◽  
Han Byul Kim ◽  
Inho Bae ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor

The role of tendon derived stem/progenitor cells and extracellular matrix components in the bone tendon junction repair

Bone ◽  
2021 ◽  
Vol 153 ◽  
pp. 116172
Author(s):  
Qin Shengnan ◽  
Samuel Bennett ◽  
Wang Wen ◽  
Li Aiguo ◽  
Xu Jiake
Keyword(s):  
Extracellular Matrix ◽  
Progenitor Cells ◽  
Extracellular Matrix Components ◽  
Matrix Components

scholarly journals Degradation of glomerular basement membrane by purified mammalian metalloproteinases

1988 ◽  
Vol 254 (2) ◽  
pp. 609-612 ◽  
Author(s):  
W H Baricos ◽  
G Murphy ◽  
Y W Zhou ◽  
H H Nguyen ◽  
S V Shah
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Degradation Products ◽  
Gel Chromatography ◽  
Collagen Types ◽  
Percentage Release ◽  
Dose Dependent

Neutral metalloproteinases degrade components of the extracellular matrix, including collagen types I-V, fibronectin, laminin and proteoglycan. However, their ability to degrade intact glomerular basement membrane (GBM) has not previously been investigated. Incubation of [3H]GBM (50,000 c.p.m.; pH 7.5; 24 h at 37 degrees C) with purified gelatinase or stromelysin (2 units) resulted in significant GBM degradation: gelatinase, 46 +/- 2.2; stromelysin, 59 +/- 5.8 (means +/- S.E.M.; percentage release of non-sedimentable radioactivity; n = 4). In contrast, 2 units of collagenase released only 5.6 +/- 0.52% (n = 3) of the [3H]GBM radioactivity compared with 2.0 +/- 0.15% (n = 7) released from [3H]GBM incubated alone. Sephadex G-200 gel chromatography of supernatants obtained from incubations of [3H]GBM with either gelatinase or stromelysin confirmed the ability of these enzymes to degrade GBM and revealed both high-(800,000) and relatively low-(less than 20,000) Mr degradation products for both enzymes. GBM degradation by gelatinase and stromelysin was dose-dependent (range 0.02-2.0 units), near maximal between pH 6.0 and 8.6, and was completely inhibited (greater than 95%) by 2 mM-o-phenanthroline. Collagenase (2 units) did not enhance the degradation of GBM by either gelatinase (0.02 or 0.2 unit) or stromelysin (0.02 or 0.2 unit). Our results indicate that metalloproteinase-mediated GBM degradation by neutrophils and glomeruli may be attributable to gelatinase (neutrophils) and/or stromelysin (glomeruli) and suggest an important role for these proteinases in glomerular pathophysiology.

scholarly journals Extracellular matrix-regulated neural differentiation of human multipotent marrow progenitor cells enhances functional recovery after spinal cord injury

2014 ◽  
Vol 14 (10) ◽  
pp. 2488-2499 ◽  
Author(s):  
Win-Ping Deng ◽  
Chi-Chiang Yang ◽  
Liang-Yo Yang ◽  
Chun-Wei D. Chen ◽  
Wei-Hong Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Extracellular Matrix ◽  
Progenitor Cells ◽  
Functional Recovery ◽  
Neural Differentiation ◽  
Cord Injury

scholarly journals Impaired adhesion of induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) to isolated extracellular matrix from failing hearts

Heliyon ◽  
2018 ◽  
Vol 4 (10) ◽  
pp. e00870
Author(s):  
Elizabeth N. McKown ◽  
Joshua L. DeAguero ◽  
Benjamin D. Canan ◽  
Ahmet Kilic ◽  
Yiliang Zhu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Cardiac Progenitor Cells ◽  
Induced Pluripotent

scholarly journals Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Francis D. Gratte ◽  
Sara Pasic ◽  
John K. Olynyk ◽  
George C. T. Yeoh ◽  
David Tosh ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Progenitor Cells ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells ◽  
Serum Dependent

scholarly journals The effects of membrane potential and extracellular matrix composition on vascular differentiation of cardiac progenitor cells

2020 ◽  
Vol 530 (1) ◽  
pp. 240-245
Author(s):  
Mark C. Daley ◽  
Mattia Bonzanni ◽  
Allison M. MacKenzie ◽  
David L. Kaplan ◽  
Lauren D. Black
Keyword(s):  
Extracellular Matrix ◽  
Membrane Potential ◽  
Progenitor Cells ◽  
Matrix Composition ◽  
Cardiac Progenitor Cells ◽  
Vascular Differentiation

The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review

2016 ◽  
Vol 201 (4) ◽  
pp. 239-252 ◽  
Author(s):  
Sonja E. Lobo ◽  
Luciano César P.C. Leonel ◽  
Carla M.F.C. Miranda ◽  
Talya M. Coelho ◽  
Guilherme A.S. Ferreira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Progenitor Cells ◽  
Fetal Development ◽  
Mammalian Species ◽  
Bioactive Molecules ◽  
High Yield ◽  
Temporal Dynamic ◽  
Embryonic And Fetal Development ◽  
And Function

The placenta is a temporal, dynamic and diverse organ with important immunological features that facilitate embryonic and fetal development and survival, notwithstanding the fact that several aspects of its formation and function closely resemble tumor progression. Placentation in mammals is commonly used to characterize the evolution of species, including insights into human evolution. Although most placentas are discarded after birth, they are a high-yield source for the isolation of stem/progenitor cells and are rich in extracellular matrix (ECM), representing an important resource for regenerative medicine purposes. Interactions among cells, ECM and bioactive molecules regulate tissue and organ generation and comprise the foundation of tissue engineering. In the present article, differences among several mammalian species regarding the placental types and classifications, phenotypes and potency of placenta-derived stem/progenitor cells, placental ECM components and current placental ECM applications were reviewed to highlight their potential clinical and biomedical relevance.

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