Despite increased physical activity levels, bone mineral density decreases after total hip arthroplasty

Abstract Background: Bone mineral density (BMD) of the proximal femur around the stem decreases due to stress shielding after cementless total hip arthroplasty (THA). When severe stress shielding occurs, the risk of periprosthetic femoral fractures increases, and this bone loss can also increase the difficulty of future revision THA. Denosumab is known to improve the quality and strength of cortical bone in the proximal femurs of patients with osteoporosis. The purpose of this study was to investigate whether denosumab prevents loss of proximal femoral periprosthetic BMD in cementless THA using a tapered wedge stem in patients with osteoporosis.Methods: Sixty-three consecutive patients who had undergone unilateral primary THA using a tapered wedge stem were included in this retrospective study. Twenty-four patients who received denosumab for osteoporosis were the denosumab group, and the 39 without denosumab were the control group. At 2 weeks, 6 months, and 12 months after THA, bone turnover markers and femoral periprosthetic BMD were measured.Results: BMD in zone 1 was significantly increased from baseline at both 6 and 12 months after THA in the denosumab group and significantly decreased in the control group. BMD in zone 7 was significantly decreased compared to baseline at both 6 and 12 months after THA in the control group, but not in the denosumab group. The use of denosumab for THA patients with osteoporosis was independently related to preventing loss of periprosthetic BMD of the femur at 12 months after surgery in zones 1 and 7 on multivariate analysis.Conclusions: Denosumab significantly increased proximal femoral periprosthetic BMD in zone 1 and prevented loss of BMD in zone 7 in patients with osteoporosis after cementless THA using a tapered wedge stem at both 6 and 12 months after surgery.

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Bone mineral density is not related to heterotopic ossification after total hip arthroplasty

International Orthopaedics ◽

10.1007/s00264-011-1446-9 ◽

2011 ◽

Vol 36 (6) ◽

pp. 1163-1166 ◽

Cited By ~ 3

Author(s):

Kunihiko Okano ◽

Kiyoshi Aoyagi ◽

Makoto Osaki ◽

Satoru Motokawa ◽

Tomoko Matsumoto

Keyword(s):

Bone Mineral Density ◽

Total Hip Arthroplasty ◽

Heterotopic Ossification ◽

Bone Mineral ◽

Hip Arthroplasty ◽

Mineral Density ◽

Total Hip

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Changes of Bone Mineral Density after Cementless Total Hip Arthroplasty: A quantitative comparison of two different implant designs

The Journal of the Korean Orthopaedic Association ◽

10.4055/jkoa.1999.34.6.1135 ◽

1999 ◽

Vol 34 (6) ◽

pp. 1135

Author(s):

Won Sik Choy ◽

Jae Hoon Ahn ◽

Kwang Won Lee ◽

Whoan Jeang Kim ◽

Ha Yong Kim ◽

...

Keyword(s):

Bone Mineral Density ◽

Total Hip Arthroplasty ◽

Bone Mineral ◽

Hip Arthroplasty ◽

Quantitative Comparison ◽

Mineral Density ◽

Total Hip ◽

Cementless Total Hip Arthroplasty

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Bone mineral density in young adults: the influence of vitamin D status, biochemical indicators, physical activity and body composition

Archives of Osteoporosis ◽

10.1007/s11657-020-0684-0 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Anna Kopiczko ◽

Monika Łopuszańska-Dawid ◽

Karol Gryko

Keyword(s):

Physical Activity ◽

Bone Mineral Density ◽

Vitamin D ◽

Body Composition ◽

Total Cholesterol ◽

Bone Mineral ◽

Activity Levels ◽

Fat Percentage ◽

Mineral Density ◽

Physical Activity Levels

Abstract Summary The aim of the study was to assess the associations of bone mineral density and bone mass with physical activity levels, vitamin D, phosphorus, magnesium, total cholesterol and triglyceride concentration and body composition in young women and men. Physical activity has the most significant effect on bone status especially in men. Purpose The aim of the study was to assess the associations of bone mineral density and bone mass with physical activity levels, vitamin D, phosphorus, magnesium, total cholesterol and triglyceride concentration and body composition in young women and men. Methods One hundred subjects aged 19–24 years were included. Bone mineral density (BMD) in distal and proximal parts was evaluated by forearm densitometry. Body composition was analysed with the use of JAWON-Medical-x-scan. The following biochemical indicators were analysed: 25(OH) D and 1,25(OH)2D, magnesium, phosphorus, total cholesterol and triglycerides. Physical activity levels were assessed by interview. Results Significant correlations between BMD and physical activity, skeletal muscle mass and body fat percentage were revealed in men. Among women, considerably weaker correlations of BMD with body composition and physical activity were noted than in men. BMD in the distal part correlated only with lean body mass, soft lean mass and body fat percentage. The strongest relationship between physical activity and bone mineral status parameters was noted for BMD in men. In women, physical activity did not affect BMD. Conclusions Physical activity has the most significant effect on bone status especially in men.

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