Phenol compound toxicity to explain feline pancytopenia?

Introduction. Since the discovery that periodontal diseases are caused by microbial plaque the interest of many scientists has been focused on oral antiseptics. There are very few mouthrinses with oral antiseptic effect originally designed in our country. One of these is Ozosept? solution. Objective. This study evaluated the effect of Ozosept? solution (phenol compound) on the oral hygiene and gingival inflammation, in comparison with Hibidex DAP? solution (chlorhexidine digluconate). Methods. Two groups, each of 21 persons, which did not significantly differ concerning Silness-L?e plaque index (PI) and L?e-Sillnes gingival index (GI), used one of the studied oral antiseptic for a 15-day period. Oral hygiene was maintained by subjects' habitual home methods, and no technique of professionally advised brushing was performed during the experimental period. Results. At the end of the study, PI and GI scores were lowered to a statistically high significance in both groups of participants in comparison to the indexes at the beginning of the study. At the end of the study, PI and GI scores did not significantly differ between the two analyzed groups. No side effects, which were recorded in the Hibidex DAP? group (tooth and filling staining 9.5% and 4.74% respectively, transitory tongue numbness 28.6% and reduced taste sensation 14.3%), were registered in the group of subjects using Ozosept? solution. Conclusion. It is concluded that Ozosept? solution is effective in the control of dental plaque - biofilm accumulation and gingival inflammation, and produces no side effects related to chlorhexidine digluconate usage.

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Experimental and Theoretical Studies of 2- (naphthalen-1-yl (piperidin-1-yl) methyl)phenol Compound

Journal of the chemical society of pakistan ◽

10.52568/000694 ◽

2020 ◽

Vol 42 (6) ◽

pp. 818-818

Author(s):

Yeliz Ula Yeliz Ula

Keyword(s):

Molecular Orbital ◽

Theoretical Data ◽

Biologically Active ◽

Oscillator Strengths ◽

Excitation Energies ◽

Petasis Reaction ◽

Vis Spectroscopy ◽

Phenol Compound ◽

Lowest Unoccupied Molecular Orbital ◽

Experimental Values

The 2- (naphthalen-1-yl (piperidin-1-yl) methyl) phenol compound is an alkylaminophenol compound and has been experimentally synthesized by the Petasis reaction. In this study Structural analysis was carried out by FT-IR, NMR, UV-Vis spectroscopy. The high antioxidant value of the compound showed that it could be a potential biologically active drug. Theoretical data support all experimental analysis of the new compound. Comparisons were made by double method. For this purpose, DFT (B3LYP) and HF methods have been used with 6-311G ++ (d, p) set. Also, the compoundand#39;s electronic and structural properties (bond lengths, bond angles and dihedral angles), the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energies, electrostatic potential (MEP), vibrational frequencies, Mulliken atomic charges, excitation energies, and oscillator strengths were calculated. As a result; the theoretical and experimental values were found to be compatible.

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