scholarly journals Genomic association and further characterisation of faecal immunoglobulin A deficiency in German Shepherd dogs

2021 ◽  
Author(s):  
Niels Grützner ◽  
Romy M. Heilmann ◽  
Ursula Tress ◽  
Iain R. Peters ◽  
Jan S. Suchodolski ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
German Shepherd ◽  
Genomic Association

scholarly journals Measurement of Immunoglobulin Concentrations in the Feces of Healthy Dogs

2004 ◽  
Vol 11 (5) ◽  
pp. 841-848 ◽  
Author(s):  
I. R. Peters ◽  
E. L. Calvert ◽  
E. J. Hall ◽  
M. J. Day
Keyword(s):  
Internal Control ◽  
Gastrointestinal Disease ◽  
Immunoglobulin A ◽  
Iga Deficiency ◽  
German Shepherd ◽  
Chronic Enteropathies ◽  
Relative Deficiency ◽  
Iga Production ◽  
Labrador Retrievers

ABSTRACT Selective immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency in humans and may be associated with chronic gastrointestinal disease. This observation has led to the suggestion that the high susceptibility of German shepherd dogs (GSD) to chronic enteropathies is related to a deficiency in mucosal IgA production. Relative deficiencies of IgA has been reported in the serum, saliva, tears, and feces of GSD both with and without alimentary disease; however, the findings of different studies are not consistent. The aim of this study was to confirm whether a relative deficiency of IgA exists in the feces of GSD. Feces were collected from healthy GSD (n = 209), Labrador retrievers (n = 96), beagles (n = 19), and miniature schnauzers (n = 32). Fecal IgA, IgM, and IgG were measured by capture enzyme-linked immunosorbent assays. Fecal IgG concentrations in the four breed groups were not significantly different. IgA concentrations were significantly greater in miniature schnauzers than in GSD (P = 0.0003) and Labradors (P = 0.0004) but not significantly different from those in beagles. IgM concentrations were significantly greater in miniature schnauzers than in GSD (P < 0.0001), Labradors (P < 0.0001), and beagles (P = 0.0098). These findings do not support the hypothesis that GSD have a relative deficiency in fecal IgA. The differences in immunoglobulin concentrations measured from a single defecation, between individuals of the same breed and between breeds, as well as the lack of an internal control molecule, make the determination of a normal reference range for all dogs impossible. Therefore, the usefulness of fecal immunoglobulin quantification for the assessment of intestinal immunoglobulin secretion in dogs is limited.

scholarly journals Cortisol and Secretory Immunoglobulin A Response to Stress in German Shepherd Dogs

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90820 ◽  
Author(s):  
Ivona Svobodová ◽  
Helena Chaloupková ◽  
Roman Končel ◽  
Luděk Bartoš ◽  
Lenka Hradecká ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
German Shepherd ◽  
Response To Stress ◽  
Secretory Immunoglobulin

Lack of Correlation between Mucosal Immunoglobulin A-positive Plasma Cell Numbers and TLR5 Genotypes in German Shepherd Dogs with Idiopathic Chronic Enteropathy

2015 ◽  
Vol 152 (2-3) ◽  
pp. 201-205 ◽  
Author(s):  
A. Lee ◽  
A. Kathrani ◽  
S.L. Priestnall ◽  
K. Smith ◽  
D. Werling ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Immunoglobulin A ◽  
German Shepherd ◽  
Cell Numbers ◽  
Chronic Enteropathy

Estimation of heritability for hip dysplasia in German Shepherd Dogs in Finland

2000 ◽  
Vol 117 (3) ◽  
pp. 97-103 ◽  
Author(s):  
M. Leppänen ◽  
K. Mäki ◽  
J. Juga ◽  
H. Saloniemi
Keyword(s):  
Hip Dysplasia ◽  
German Shepherd

Lactate Dehydrogenase-Linked Immunoglobulin A K in a Patient with Nonimmune Chronic Idiopathic Neutropenia

2006 ◽  
Vol 12 (3) ◽  
pp. 148-151
Author(s):  
Noriko Ihara ◽  
Ikuo Murohashi ◽  
Masako Itho ◽  
Ikuo Amino ◽  
Katsuhiko Yoshida ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Immunoglobulin A ◽  
Chronic Idiopathic Neutropenia

The effect of probiotics on the level of immunoglobulin A in women with violation of the biocenosis of the vagina

2017 ◽  
pp. 85-88
Author(s):  
O.I. Ostapenko ◽  
◽  
V.P. Kvashenko ◽  
I.K. Akimova ◽  
I.N. Nosova ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Lactobacillus Rhamnosus ◽  
Test System ◽  
Main Group ◽  
Reproductive Age ◽  
Local Action ◽  
Serum Immunoglobulin ◽  
Control Group ◽  
Local Immunity ◽  
Serum Iga

The objective: the study of immunomodulatory effects of a probiotic, which contains lyophilized Lactobacillus (Lactobacillus rhamnosus) – 13 mg (2,0ґ109 CFU) and lyophilized bifidobacteria (Bifidobacterium lactis) – 4 mg (2,0ґ109 CFU) the level of serum immunoglobulin IgA as a marker of local immunity in the plasma of women of reproductive age with the violation of the biocenosis of the vagina. Patients and methods. The study involved 86 patients of reproductive age with the violation of the vaginal biocenosis, which were divided into two groups according to received treatment. A survey was conducted for all patients in both groups: determine the level of serum IgA, measuring pH of vaginal environment and the quantification of lactobacilli and pathogenic flora with the help of test-system «Florotsenoz» before treatment and in 6 weeks after treatment. The state of vaginal microbiocenosis in both groups before treatment was homogeneous. Patients in both groups as therapy at the first stage of treatment received, if necessary antimicrobial therapy depending on the selected flora. In the second stage (restoration of microflora) patient of the main group received systemic probiotic combined with a complex prebiotic local action, patients in the control group, the probiotic localy in the form of the vaginal candles or tablets. Results. The research stated the increasing level of serum IgA in blood plasma of patients of the main group compared to control group at 20%, normalizing the pH of the vaginal environment in the main group in 94% of cases, which indicates an increase of immunity in mucosal. Conclusion. The inclusion of the systemic probiotic in the scheme of treatment of disorders of biocenosis of the vagina system enhances the increasing of immunity of the mucous membranes, and the vaginal tablets prebiotic of local action restores the own normal microflora of the vagina. Key words: serum immunoglobulin A, local immunity, vaginal dysbiosis, probiotics, prebiotics, vaginal microbiocenosis, the pH of the vaginal environment.

In atopic dermatitis patients, immunoglobulin A secretion to a body surface lowers.

1994 ◽  
Vol 56 (5) ◽  
pp. 919-926
Author(s):  
SHUHEI IMAYAMA
Keyword(s):  
Atopic Dermatitis ◽  
Body Surface ◽  
Immunoglobulin A
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