Synaptic Plasma Membrane Structure and Polarity of Long-Sleep and Short-Sleep Mice

1994 ◽  
Vol 309 (2) ◽  
pp. 369-376 ◽  
Author(s):  
F. Schroeder ◽  
S.M. Colles ◽  
G.P. Kreishman ◽  
C.E. Heyliger ◽  
W.G. Wood
Keyword(s):  
Plasma Membrane ◽  
Membrane Structure ◽  
Synaptic Plasma Membrane ◽  
Short Sleep ◽  
Long Sleep

Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank

2021 ◽  
Author(s):  
Sizhi Ai ◽  
Jihui Zhang ◽  
Guoan Zhao ◽  
Ningjian Wang ◽  
Guohua Li ◽  
...  
Keyword(s):  
Heart Disease ◽  
Arterial Hypertension ◽  
Ischaemic Heart Disease ◽  
Sleep Duration ◽  
Mendelian Randomization ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Causal Risk Factor ◽  
Long Sleep ◽  
Artery Disease

Abstract Aims Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences have not been confirmed. We aimed to determine the causal associations between genetically predicted sleep duration and 12 CVDs using both linear and nonlinear Mendelian randomization (MR) designs. Methods and results Genetic variants associated with continuous, short (≤6 h) and long (≥9 h) sleep durations were used to examine the causal associations with 12 CVDs among 404 044 UK Biobank participants of White British ancestry. Linear MR analyses showed that genetically predicted sleep duration was negatively associated with arterial hypertension, atrial fibrillation, pulmonary embolism, and chronic ischaemic heart disease after correcting for multiple tests (P < 0.001). Nonlinear MR analyses demonstrated nonlinearity (L-shaped associations) between genetically predicted sleep duration and four CVDs, including arterial hypertension, chronic ischaemic heart disease, coronary artery disease, and myocardial infarction. Complementary analyses provided confirmative evidence of the adverse effects of genetically predicted short sleep duration on the risks of 5 out of the 12 CVDs, including arterial hypertension, pulmonary embolism, coronary artery disease, myocardial infarction, and chronic ischaemic heart disease (P < 0.001), and suggestive evidence for atrial fibrillation (P < 0.05). However, genetically predicted long sleep duration was not associated with any CVD. Conclusion This study suggests that genetically predicted short sleep duration is a potential causal risk factor of several CVDs, while genetically predicted long sleep duration is unlikely to be a causal risk factor for most CVDs.

scholarly journals Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyriaki Papantoniou ◽  
Gemma Castaño-Vinyals ◽  
Ana Espinosa ◽  
Michelle C. Turner ◽  
Vicente Martín-Sánchez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Sleep Duration ◽  
Night Shift ◽  
Work History ◽  
Logistic Regression Models ◽  
Short Sleep ◽  
Long Sleep ◽  
Adjusted Logistic Regression ◽  
Population Controls ◽  
Control Study

AbstractSleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case–control study (2008–2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30–1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37–2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93–1.88). Frequent and long daytime naps increased the odds of colorectal (OR6–7 naps/week, ≥30 min: 1.32; 1.14–1.54) and gastric cancer (OR6–7 naps/week, ≥30 min: 1.56; 1.21–2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.

A modified liquid-mosaic model of plasma membrane structure

1998 ◽  
Vol 30 (4-5) ◽  
pp. 328-329 ◽  
Author(s):  
V. K. Rybal'chenko
Keyword(s):  
Plasma Membrane ◽  
Membrane Structure ◽  
Mosaic Model

Differences in the urocortin 1 system between long-sleep and short-sleep mice

2007 ◽  
Vol 0 (0) ◽  
pp. 070629195945001-???
Author(s):  
Victoria F. Turek ◽  
Beth Bennett ◽  
Andrey E. Ryabinin
Keyword(s):  
Short Sleep ◽  
Long Sleep ◽  
Urocortin 1

Interpretation of yeast plasma membrane structure

Micron (1969) ◽  
1980 ◽  
Vol 11 (3-4) ◽  
pp. 359-364 ◽  
Author(s):  
S. Bullivant
Keyword(s):  
Plasma Membrane ◽  
Membrane Structure ◽  
Yeast Plasma Membrane

Duchenne dystrophy: alteration in muscle plasma membrane structure

Science ◽  
1977 ◽  
Vol 196 (4293) ◽  
pp. 1005-1007 ◽  
Author(s):  
D. Schotland ◽  
E Bonilla ◽  
M Van Meter
Keyword(s):  
Plasma Membrane ◽  
Membrane Structure ◽  
Duchenne Dystrophy ◽  
Muscle Plasma Membrane

Immunologic identification of exchange protein in rat brain synaptic plasma membrane

1992 ◽  
Vol 136 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Rick K. Yip ◽  
Mordecai P. Blaustein ◽  
Kenneth D. Philipson
Keyword(s):  
Plasma Membrane ◽  
Rat Brain ◽  
Synaptic Plasma Membrane ◽  
Exchange Protein
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