Inhibitors of Calcineurin Block Expression of Cyclins A and E Induced by Fibroblast Growth Factor in Swiss 3T3 Fibroblasts

1998 ◽  
Vol 353 (2) ◽  
pp. 374-378 ◽  
Author(s):  
Masahiro Tomono ◽  
Kotaro Toyoshima ◽  
Motohiro Ito ◽  
Hisao Amano ◽  
Zoltan Kiss
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
3T3 Fibroblasts ◽  
Swiss 3T3 ◽  
Swiss 3T3 Fibroblasts

scholarly journals Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 ◽  
Vol 261 (3) ◽  
pp. 1187-1192
Author(s):  
K Kaibuchi ◽  
T Tsuda ◽  
A Kikuchi ◽  
T Tanimoto ◽  
T Yamashita ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Growth Factor ◽  
Protein Kinase ◽  
Calcium Ion ◽  
Induced Expression ◽  
Myc Oncogene ◽  
3T3 Fibroblasts ◽  
Kinase C ◽  
Swiss 3T3 ◽  
Swiss 3T3 Fibroblasts

Basic fibroblast growth factor induces 3T3 fibroblasts to synthesize and secrete a cyclophilin-like protein and β2-microglobulin

1991 ◽  
Vol 1095 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Thomas R. Davis ◽  
Louisa Tabatabai ◽  
Kerry Bruns ◽  
Richard T. Hamilton ◽  
Marit Nilsen-Hamilton
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Β2 Microglobulin ◽  
3T3 Fibroblasts

Control of entry of Swiss 3T3 cells into S phase by fibroblast growth factor under serum-free conditions

1983 ◽  
Vol 146 (2) ◽  
pp. 261-270 ◽  
Author(s):  
Gary D. Shipley ◽  
Richard G. Ham
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
S Phase ◽  
Fibroblast Growth ◽  
3T3 Cells ◽  
Serum Free ◽  
Swiss 3T3 ◽  
Serum Free Conditions

scholarly journals Functional Proteomic Analysis of Long-term Growth Factor Stimulation and Receptor Tyrosine Kinase Coactivation in Swiss 3T3 Fibroblasts

2012 ◽  
Vol 11 (12) ◽  
pp. 1690-1708 ◽  
Author(s):  
Kohji Nagano ◽  
Akunna Akpan ◽  
Gayathri Warnasuriya ◽  
Steven Corless ◽  
Nick Totty ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Proteomic Analysis ◽  
3T3 Fibroblasts ◽  
Swiss 3T3 ◽  
Swiss 3T3 Fibroblasts

scholarly journals Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts

1996 ◽  
Vol 313 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Andrew J. SAURIN ◽  
Jane HAMLETT ◽  
Michael J. CLAGUE ◽  
Stephen R. PENNINGTON
Keyword(s):  
Growth Factor ◽  
Dna Synthesis ◽  
Kinase Activity ◽  
Bafilomycin A1 ◽  
Tyrosine Kinase Activity ◽  
3T3 Fibroblasts ◽  
Mitogenic Signalling ◽  
Epidermal Growth ◽  
Swiss 3T3 ◽  
Swiss 3T3 Fibroblasts

Quiescent cells (in G0) can be stimulated to enter the cell cycle and proceed to DNA synthesis in S-phase by a wide range of growth factors and mitogens. Activation of cell-surface growth factor receptors with intrinsic protein tyrosine kinase activity initiates autophosphorylation of the receptors and subsequent activation of signal transduction cascades. After activation the receptors undergo ligand-induced internalization to endosomes, which become acidified by the action of a vacuolar H+-ATPase (V-ATPase). The extent to which vesicular acidification plays a role in mitogenic signalling by receptors with intrinsic tyrosine kinase activity remains unknown. Here we have shown that bafilomycin A1, a specific inhibitor of V-ATPase, inhibits endosome acidification and mitogen-induced DNA synthesis in Swiss 3T3 fibroblasts. Addition of bafilomycin A1 at successively later times during G1 progressively decreased the inhibition of DNA synthesis such that no inhibition was observed when bafilomycin A1 was added at the onset of S-phase. Bafilomycin A1 also induced a dramatic but reversible change in the morphology of Swiss 3T3 cells. However, the rapid activation of c-fos mRNA accumulation by epidermal growth factor and insulin was unaffected by bafilomycin A1. Together, the results suggest that activation of the V-ATPase plays an important role in the mitogenic signalling pathways that occur during the G1 phase of the cell cycle but is not required for the initial epidermal growth factor and insulin-evoked signalling events that lead to c-fos mRNA expression.

Acidic fibroblast growth factor overexpression partially protects 3T3 fibroblasts from apoptosis induced by synthetic retinoid CD437

2001 ◽  
Vol 79 (2-3) ◽  
pp. 143-148 ◽  
Author(s):  
Xiaolin Wan ◽  
Petra Nass ◽  
Mark D. Duncan ◽  
John W. Harmon
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
3T3 Fibroblasts ◽  
Synthetic Retinoid
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