An Improved Fluorometric High-Performance Liquid Chromatography Method for Sialic Acid Determination: An Internal Standard Method and Its Application to Sialic Acid Analysis of Human Apolipoprotein E

2002 ◽  
Vol 304 (2) ◽  
pp. 276
Author(s):  
Masaki Ito ◽  
Kiyoshi Ikeda ◽  
Yuki Suzuki ◽  
Kiyoshi Tanaka ◽  
Megumi Saito
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Sialic Acid ◽  
High Performance ◽  
Internal Standard ◽  
Internal Standard Method ◽  
Chromatography Method ◽  
Human Apolipoprotein ◽  
Liquid Chromatography Method ◽  
Acid Determination

scholarly journals Development, Validation, and Routine Application of a High-Performance Liquid Chromatography Method Coupled with a Single Mass Detector for Quantification of Itraconazole, Voriconazole, and Posaconazole in Human Plasma

2010 ◽  
Vol 54 (8) ◽  
pp. 3408-3413 ◽  
Author(s):  
Lorena Baietto ◽  
Antonio D'Avolio ◽  
Giusi Ventimiglia ◽  
Francesco Giuseppe De Rosa ◽  
Marco Siccardi ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Internal Standard ◽  
Limit Of Quantification ◽  
Chromatography Method ◽  
True Value ◽  
Relative Standard ◽  
Mass Detector ◽  
Liquid Chromatography Method

ABSTRACT We have developed and validated a high-performance liquid chromatography method coupled with a mass detector to quantify itraconazole, voriconazole, and posaconazole using quinoxaline as the internal standard. The method involves protein precipitation with acetonitrile. Mean accuracy (percent deviation from the true value) and precision (relative standard deviation percentage) were less than 15%. Mean recovery was more than 80% for all drugs quantified. The lower limit of quantification was 0.031 μg/ml for itraconazole and posaconazole and 0.039 μg/ml for voriconazole. The calibration range tested was from 0.031 to 8 μg/ml for itraconazole and posaconazole and from 0.039 to 10 μg/ml for voriconazole.

Fast determination of omeprazole in extemporaneous suspensions used in paediatrics and stability studies

2019 ◽  
Vol 11 (4) ◽  
pp. 517-523 ◽  
Author(s):  
Kateřina Kučerová ◽  
Veronika Reiská ◽  
František Švec ◽  
Lenka Kujovská Krčmová ◽  
Ludmila Matysová
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Internal Standard ◽  
Uv Detection ◽  
Stability Studies ◽  
Chromatography Method ◽  
Fast Determination ◽  
Liquid Chromatography Method

A simple and fast ultra-high-performance liquid chromatography method with UV detection for the separation and quantification of omeprazole and the impurities of omeprazole and methylparaben (the internal standard) in six extemporaneous suspensions has been developed and fully validated.

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