Gene Transcription of Angiotensin II Type 2 Receptor Is Repressed by Growth Factors and Glucocorticoids in PC12 Cells

1995 ◽  
Vol 216 (1) ◽  
pp. 359-366 ◽  
Author(s):  
K. Kijima ◽  
H. Matsubara ◽  
S. Murasawa ◽  
K. Maruyama ◽  
Y. Mori ◽  
...  
Keyword(s):  
Growth Factors ◽  
Angiotensin Ii ◽  
Pc12 Cells ◽  
Gene Transcription

scholarly journals Down-Regulation by cAMP of Angiotensin II Type 2 Receptor Gene Expression in PC12 Cells.

1996 ◽  
Vol 19 (4) ◽  
pp. 271-279 ◽  
Author(s):  
Satoshi Murasawa ◽  
Hiroaki Matsubara ◽  
Kazuhisa Kijima ◽  
Katsuya Maruyama ◽  
Naohiko Ohkubo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Angiotensin Ii ◽  
Pc12 Cells ◽  
Receptor Gene ◽  
Down Regulation ◽  
Receptor Gene Expression

Multiple Growth Factors Modulate mRNA Expression of Angiotensin II Type-2 Receptor in R3T3 Cells

1995 ◽  
Vol 77 (6) ◽  
pp. 1070-1076 ◽  
Author(s):  
Toshihiro Ichiki ◽  
Yoshikazu Kambayashi ◽  
Tadashi Inagami
Keyword(s):  
Growth Factors ◽  
Angiotensin Ii ◽  
Mrna Expression

Modulation of angiotensin II type 2 receptor mRNA in rat hypothalamus and brainstem neuronal cultures by growth factors

1997 ◽  
Vol 47 (1-2) ◽  
pp. 229-236 ◽  
Author(s):  
X.-C Huang ◽  
U.V Shenoy ◽  
E.M Richards ◽  
C Sumners
Keyword(s):  
Growth Factors ◽  
Angiotensin Ii ◽  
Neuronal Cultures ◽  
Rat Hypothalamus ◽  
Receptor Mrna

Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription

2001 ◽  
Vol 268 (6) ◽  
pp. 1802-1810
Author(s):  
Danielle Naville ◽  
Estelle Bordet ◽  
Marie-Claude Berthelon ◽  
Philippe Durand ◽  
Martine Begeot
Keyword(s):  
Angiotensin Ii ◽  
Gene Transcription ◽  
Receptor Gene ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Stimulation Of

Anti-Hypertensive Potential and Epigenetics of Angiotensin II type 2 Receptor (AT2R)

2020 ◽  
Vol 16 ◽  
Author(s):  
Mayank Chaudhary
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Renin Angiotensin System ◽  
Blood Pressure Regulation ◽  
Biologically Active ◽  
Pressure Regulation ◽  
Tissue Remodelling ◽  
Critical Pathway

Background:: Renin angiotensin system (RAS) is a critical pathway involved in blood pressure regulation. Octapeptide, angiotensin II (Ang aII), is biologically active compound of RAS pathway which mediates its action by binding to either angiotensin II type 1 receptor (AT1R) or angiotensin II type 2 receptor (AT2R). Binding of Ang II to AT1R facilitates blood pressure regulation whereas AT2R is primarily involved in wound healing and tissue remodelling. Objective:: Recent studies have highlighted additional role of AT2R to counter balance detrimental effects of AT1R. Activation of angiotensin II type 2 receptor using AT2R agonist has shown effect on natriuresis and release of nitric oxide. Additionally, AT2R activation has been found to inhibit angiotensin converting enzyme (ACE) and enhance angiotensin receptor blocker (ARB) activity. These findings highlight the potential of AT2R as novel therapeutic target against hypertension. Conclusion:: The potential role of AT2R highlights the importance of exploring additional mechanisms that might be crucial for AT2R expression. Epigenetic mechanisms including DNA methylation and histone modification have been explored vastly with relation to cancer but role of such mechanisms on expression of AT2R has recently gained interest.

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