International Association of Biological Standardization: Task Force on Vaccines

Biologicals ◽  
1994 ◽  
Vol 22 (3) ◽  
pp. 203-204
Crisis ◽  
2007 ◽  
Vol 28 (3) ◽  
pp. 122-130 ◽  
Author(s):  
Marc S. Daigle ◽  
Anasseril E. Daniel ◽  
Greg E. Dear ◽  
Patrick Frottier ◽  
Lindsay M. Hayes ◽  
...  

Abstract. The International Association for Suicide Prevention created a Task Force on Suicide in Prisons to better disseminate the information in this domain. One of its objectives was to summarize suicide-prevention activities in the prison systems. This study of the Task Force uncovered many differences between countries, although mental health professionals remain central in all suicide prevention activities. Inmate peer-support and correctional officers also play critical roles in suicide prevention but there is great variation in the involvement of outside community workers. These differences could be explained by the availability of resources, by the structure of the correctional and community services, but mainly by the different paradigms about suicide prevention. While there is a common and traditional paradigm that suicide prevention services are mainly offered to individuals by mental health services, correctional systems differ in the way they include (or not) other partners of suicide prevention: correctional officers, other employees, peer inmates, chaplains/priests, and community workers. Circumstances, history, and national cultures may explain such diversity but they might also depend on the basic way we think about suicide prevention at both individual and environmental levels.


2021 ◽  
Author(s):  
Duncan James McLachlan ◽  
Changlih Ee ◽  
Jeroen Veen ◽  
Fabien Cochet ◽  
Daniele Tomassi ◽  
...  

Objectives/Scope Systems engineering techniques, particularly requirements management, are critical to realizing the value of digital transformation to improve capital project delivery. Drawing on the results of a case study, this paper will demonstrate the value of using digital requirements management to exchange information through a project lifecycle, specifically showing benefits in the integrity of data transfer; more efficient procurement lifecycle; more robust deviation management; and bidirectional traceability of requirements, including full visibility and end to end verification and validation. Methods, Procedures, Process A requirement is a capability to which a project outcome (product or service) should conform, and the purpose of requirements management is to ensure that an organization documents, verifies and validates these capabilities. In this case study the operator provides their technical specifications in the form of requirements. These requirements are then imported into the EPC's PLM platform, where they are supplemented with additional information from the EPC's engineers to create a requirements-based requisition package. This is then transmitted to the equipment supplier, where it is reviewed and, for the purposes of the case study, reviewed for completeness. To test the ability to identify changes and deviations, the EPC engineer modified the requirements and the file was transferred to both the operator and equipment supplier to ensure the changes were transferred and were identifiable. The case study also demonstrates how verification activities (testing, commissioning, etc.) can be linked to requirements; passed through the supply chain and be modified to capture changes to the status of the activity (such as test results). Results, Observations, Conclusions The case studies described show how requirements can be exchanged between operator, EPC and equipment supplier without any loss of data. It will also show how this approach allows a data driven approach, as opposed to a document driven approach, to be deployed in the requisitioning process, which could facilitate substantial reduction in the procurement lifecycle. This is achieved by removing extraneous information exchanged between the companies; the removal of swivel chair solutions, where data is extracted from one system and transferred to another; and expediting the bid evaluation stage. Finally, the case study will demonstrate how this approach could be extended beyond the purchase order to provide a direct link between specific requirements and testing (FATs) or commissioning activities, which facilitates a more efficient process for verification as well as ensuring a digital record of the entire lifecycle of a package. The case study highlighted the importance of aligning data model and developing workflows, these findings are captured in the lessons learned section and have been shared with the International Association of Oil and Gas Producers (IOGP) Requirements Digitalization Task Force (RDTF). Novel/Additive Information The paper will also include a vision of requirements models can be used to establish a holistic requirements model of a project, including the interdependencies of different system components. The case study will also demonstrate how the adoption of a common data standard for requirements allows a software agnostic solution that can be adopted by all.


Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 214
Author(s):  
David Hui ◽  
Eman Abdelghani ◽  
Joseph Chen ◽  
Shiva Dibaj ◽  
Donna Zhukovsky ◽  
...  

Palliative care is seeing cancer patients earlier in the disease trajectory with a multitude of chronic issues. Chronic non-malignant pain (CNMP) in cancer patients is under-studied. In this prospective study, we examined the prevalence and management of CNMP in cancer patients seen at our supportive care clinic for consultation. We systematically characterized each pain type with the Brief Pain Inventory (BPI) and documented current treatments. The attending physician made the pain diagnoses according to the International Association for the Study of Pain (IASP) task force classification. Among 200 patients (mean age 60 years, 69% metastatic disease, 1-year survival of 77%), the median number of pain diagnosis was 2 (IQR 1–2); 67 (34%, 95% CI 28–41%) had a diagnosis of CNMP; 133 (67%) had cancer-related pain; and 52 (26%) had treatment-related pain. In total, 12/31 (39%) patients with only CNMP and 21/36 (58%) patients with CNMP and other pain diagnoses were on opioids. There was a total of 94 CNMP diagnoses among 67 patients, including 37 (39%) osteoarthritis and 20 (21%) lower back pain; 30 (32%) were treated with opioids. In summary, CNMP was common in the timely palliative care setting and many patients were on opioids. Our findings highlight the need to develop clinical guidelines for CNMP in cancer patients to standardize its management.


2007 ◽  
Vol 12 (4) ◽  
pp. 245-248 ◽  
Author(s):  
Mary E Lynch ◽  
Fiona A Campbell ◽  
Alexander J Clark ◽  
Michael J Dunbar ◽  
David Goldstein ◽  
...  

As medical costs escalate, health care resources must be prioritized. In this context, there is an increasing need for benchmarks and best practices in wait time management. In December 2005, the Canadian Pain Society struck a Task Force to identify benchmarks for acceptable wait times for treatment of chronic pain. The task force mandate included a systematic review and survey to identify national or international wait time benchmarks for chronic pain, proposed or in use, along with a review of the evidence upon which they are based. An extensive systematic review of the literature and a survey of International Association for the Study of Pain Chapter Presidents and key informants has identified that there are no established benchmarks or guidelines for acceptable wait times for the treatment of chronic pain in use in the world. In countries with generic guidelines or wait time standards that apply to all outpatient clinics, there have been significant challenges faced by pain clinics in meeting the established targets. Important next steps are to ensure appropriate additional research and the establishment of international benchmarks or guidelines for acceptable wait times for the treatment of chronic pain. This will facilitate advocacy for improved access to appropriate care for people suffering from chronic pain around the world.


2013 ◽  
Vol 2s;16 (2s;4) ◽  
pp. SE55-SE95
Author(s):  
Laxmaiah Manchikanti

Background: The intervertebral disc has been implicated as a major cause of chronic lumbar spinal pain based on clinical, basic science, and epidemiological research. There is, however, a lack of consensus regarding the diagnosis and treatment of intervertebral disc disorders. Based on controlled evaluations, lumbar intervertebral discs have been shown to be the source of chronic back pain without disc herniation in 26% to 39% of patients. Lumbar provocation discography, which includes disc stimulation and morphological evaluation, is often used to distinguish a painful disc from other potential sources of pain. Despite the extensive literature, intense debate continues about lumbar discography as a diagnostic tool. Study Design: A systematic review of the diagnostic accuracy of lumbar provocation and analgesic discography literature. Objective: To systematically assess and re-evaluate the diagnostic accuracy of lumbar discography. Methods: The available literature on lumbar discography was reviewed. A methodological quality assessment of included studies was performed using the Quality Appraisal of Reliability Studies (QAREL) checklist. Only diagnostic accuracy studies meeting at least 50% of the designated inclusion criteria were included in the analysis. However, studies scoring less than 50% are presented descriptively and critically analyzed. The level of evidence was classified as good, fair, and limited or poor based on the quality of evidence developed by the U.S. Preventive Services Task Force (USPSTF). Data sources included relevant literature identified through searches of PubMed and EMBASE from 1966 to September 2012, and manual searches of the bibliographies of known primary and review articles. Results: Over 160 studies were considered for inclusion. Of these, 33 studies compared discography with other diagnostic tests, 30 studies assessed the diagnostic accuracy of discography, 22 studies assessed surgical outcomes for discogenic pain, and 3 studies assessed the prevalence of lumbar discogenic pain. The quality of the overall evidence supporting provocation discography based on the above studies appears to be fair. The prevalence of internal disc disruption is estimated to be 39% to 42%, whereas the prevalence of discogenic pain without assessing internal disc disruption is 26%. Conclusion: This systematic review illustrates that lumbar provocation discography performed according to the International Association for the Study of Pain (IASP) criteria may be a useful tool for evaluating chronic lumbar discogenic pain. Key words: Lumbar intervertebral disc, lumbar discography, provocation discography, analgesic discography, diagnostic accuracy


2020 ◽  
Author(s):  
Patrick Alken ◽  
Erwan Thebault ◽  
Ciaran Beggan ◽  
Julien Aubert ◽  
Julien Baerenzung ◽  
...  

Abstract In December 2019, the 13th revision of the International Geomagnetic Reference Field (IGRF) was released by the International Association of Geomagnetism and Aeronomy (IAGA) Division V Working Group V-MOD. This revision comprises two new spherical harmonic main field models for epochs 2015.0 (DGRF-2015) and 2020.0 (IGRF-2020) and a model of the predicted secular variation for the interval 2020.0 to 2025.0 (SV-2020-2025). The models were produced from candidates submitted by fifteen international teams. These teams were led by the British Geological Survey (UK), China Earthquake Administration (China), Universidad Complutense de Madrid (Spain), University of Colorado Boulder (USA), Technical University of Denmark (Denmark), GFZ German Research Centre for Geosciences (Germany), Institut de physique du globe de Paris (France), Institut des Sciences de la Terre (France), Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation (Russia), Kyoto University (Japan), University of Leeds (UK), Max Planck Institute for Solar System Research (Germany), NASA Goddard Space Flight Center (USA), University of Potsdam (Germany), and Universit\'e de Strasbourg (France). The candidate models were evaluated individually and compared to all other candidates as well to the mean, median and a robust Huber-weighted model of all candidates. These analyses were used to identify, for example, the variation between the Gauss coefficients or the geographical regions where the candidate models strongly differed. The majority of candidates were sufficiently close that the differences can be explained primarily by individual modeling methodologies and data selection strategies. None of the candidates were so different as to warrant their exclusion from the final IGRF-13. The IAGA V-MOD task force thus voted for two approaches: the median of the Gauss coefficients of the candidates for the DGRF-2015 and IGRF-2020 models and the robust Huber-weighted model for the predictive SV-2020-2025. In this paper, we document the evaluation of the candidate models and provide details of the approach used to derive the final IGRF-13 products. We also perform a retrospective analysis of the IGRF-12 SV candidates over their performance period (2015-2020). Our findings suggest that forecasting secular variation can benefit from combining physics-based core modeling with satellite observations.


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