Zinc-Dependent Activation of the Plasma Kinin-Forming Cascade by Aggregated β Amyloid Protein

1999 ◽  
Vol 90 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Yoji Shibayama ◽  
Kusumam Joseph ◽  
Yoshitaka Nakazawa ◽  
Berhane Ghebreihiwet ◽  
Ellinor I.B. Peerschke ◽  
...  
Keyword(s):  
Amyloid Protein ◽  
Β Amyloid ◽  
Plasma Kinin

scholarly journals Protective effect by T-588 against β-amyloid protein-induced microglial cell death

1999 ◽  
Vol 79 ◽  
pp. 51
Author(s):  
Takashi Fujita ◽  
Yuji Kimura ◽  
Yoko Komeda ◽  
Kazuhiro Takuma ◽  
Toshio Matsuda ◽  
...  
Keyword(s):  
Cell Death ◽  
Protective Effect ◽  
Microglial Cell ◽  
Amyloid Protein ◽  
Β Amyloid

scholarly journals Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Aβ peptide [Aβ(25–35)]

1998 ◽  
Vol 336 (2) ◽  
pp. 419-427 ◽  
Author(s):  
Omar M. A. EL-AGNAF ◽  
G. Brent IRVINE ◽  
Geraldine FITZPATRICK ◽  
W. Kenneth GLASS ◽  
David J. S. GUTHRIE
Keyword(s):  
Electron Microscopy ◽  
Ligand Binding ◽  
Comparative Studies ◽  
Aβ Peptide ◽  
Amyloid Protein ◽  
Binding Studies ◽  
Nk1 Receptors ◽  
Ligand Displacement ◽  
Β Amyloid

In an attempt to answer the question of whether or not the so-called tachykinin-like region of the Alzheimer β-amyloid protein [Aβ(25–35)] can act as a tachykinin, the sequences Aβ(25–35), Aβ(25–35)amide and their norleucine-35 and phenylalanine-31 analogues were synthesized. These peptides were examined with ligand binding studies, electron microscopy, CD and NMR. In all cases some differences were found between the Aβ(25–35) analogue and the corresponding Phe31 peptide. In addition, in ligand displacement studies on tachykinin NK1 receptors, only the Phe31 analogue showed activity comparable to that of genuine tachykinins. We conclude that peptides based on Aβ(25–35) but with a Phe residue at position 31 do display properties typical of a tachykinin, but that peptides with Ile at this position do not.

Distance-based β-amyloid protein detection on PADs for scanning and subsequent follow up of Alzheimer’s disease in human urine sample

The Analyst ◽  
2022 ◽  
Author(s):  
Kawin Khachornsakkul ◽  
Anongnat Tiangtrong ◽  
Araya Suwannasom ◽  
Wuttichai Sangkharoek ◽  
Opor Jamjumrus ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Urine ◽  
Protein Detection ◽  
Protein Quantification ◽  
Amyloid Protein ◽  
Human Urine Sample ◽  
Amyloid Aβ ◽  
Β Amyloid

We report on the first development of a simple distance-based β-amyloid (Aβ) protein quantification using paper-based devices (dPADs) to screen for Alzheimer’s disease (AD) and to subsequently follow up on...

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