Spontaneous Secretion of Immunoglobulins and Anti-HIV-1 Antibodies by in Vivo Activated B Lymphocytes from HIV-1-Infected Subjects: Monocyte and Natural Killer Cell Requirement for in Vitro Terminal Differentiation into Plasma Cells

2002 ◽  
Vol 103 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Anne Marie Fournier ◽  
Jean-Michel Fondere ◽  
Catherine Alix-Panabieres ◽  
Corinne Merle ◽  
Vincent Baillat ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
B Lymphocytes ◽  
Plasma Cells ◽  
Killer Cell ◽  
Terminal Differentiation ◽  
Spontaneous Secretion ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals A cloned cell line mediating natural killer cell function inhibits immunoglobulin secretion.

1982 ◽  
Vol 156 (2) ◽  
pp. 658-663 ◽  
Author(s):  
G Nabel ◽  
W J Allard ◽  
H Cantor
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Cell Line ◽  
B Lymphocytes ◽  
Cell Function ◽  
Killer Cell ◽  
Major Histocompatibility Complex Gene ◽  
Cell Surface Antigens

We previously described a cloned cell line that combines information for a unique display of cell surface antigens and specialized function similar to activated natural killer (NK) cells. In addition to conventional cellular targets such as the YAC-1 and MBL-2 lymphomas, this cloned line also lysed lipopolysaccharide-activated B lymphocytes. To determine whether some NK cells can inhibit B cell function, we tested the ability of NK-like clones to suppress Ig secretion in vitro and in vivo. These cloned cells suppressed Ig secretion when they constituted as few as 0.2% of the total cell population and inhibition did not require identity at the H-2 locus. We suggest that some NK cells might recognize non-major histocompatibility complex gene products on activated B lymphocytes and lyse these cells, and this might represent a fundamental cell-cell interaction that regulates antibody secretion by activated B cells.

scholarly journals In Vitro and In Silico Antioxidant, Anti-Diabetic, Anti-HIV and Anti-Alzheimer Activity of Endophytic Fungi, Cladosporium uredinicola Phytochemicals

2019 ◽  
Vol 13 ◽  
pp. 13-34
Author(s):  
Melappa Govindappa ◽  
V. Thanuja ◽  
S. Tejashree ◽  
C.A. Soukhya ◽  
Suresh Barge ◽  
...  
Keyword(s):  
Qualitative Method ◽  
Cholinesterase Activity ◽  
Methanol Extract ◽  
High Binding Energy ◽  
Acetyl Cholinesterase ◽  
Gp 120 ◽  
Anti Hiv ◽  
Hiv 1

The present work was aimed to identify phytochemicals in C. uredinicola methanol extract from qualitative, TLC and GC-MS method and evaluated for antioxidant, anti-HIV, anti-diabetes, anti-cholinesterase activity in vitro and in silico. The C. uredinicola extract showed flavonoids, tannins, alkaloids, glycosides, phenols, terpenoids, and coumarins presence in qualitative method. From GC-MS analysis, identified seven different phytochemicals and out of seven, four (coumarin, coumarilic acid, hymecromone, alloisoimperatorin) are coumarins. The C. uredinicola extract have shown significant antioxidant activity in DPPH (73) and FRAP (1359) method. The HIV-1 RT (83.81+2.14), gp 120 (80.24+2.31), integrase (79.43+3.14) and protease (77.63+2.14), DPPIV, β-glucosidase and acetyl cholinesterase activity was significantly reduced by the extract. The 2-diphenylmethyleneamino methyl ester had shown significant interaction with oxidant and HIV-1 proteins whereas alloisoimperatorin have interacted with diabetes and cholinesterase proteins followed by hymecromone with high binding energy. These three phytochemicals are non-carcinogens, non-toxic, readily degradable and have drug likeliness properties. The C. uredinicola phytochemicals are responsible for management of diabetes, HIV-1 and Alzheimer. Further in vivo work is needed to justify our research.

Lactoferrin nanoparticles coencapsulated with curcumin and tenofovir improve vaginal defense against HIV-1 infection

Nanomedicine ◽  
2021 ◽  
Author(s):  
Samrajya Lakshmi Yeruva ◽  
Prashant Kumar ◽  
Seetharam Deepa ◽  
Anand K Kondapi
Keyword(s):  
Physicochemical Characterization ◽  
Systemic Circulation ◽  
Application Site ◽  
Drug Nanoparticles ◽  
In Vivo Experiments ◽  
Hiv Microbicide ◽  
Anti Hiv ◽  
Hiv 1

Aim: We report here the development of tenofovir- and curcumin-loaded lactoferrin nanoparticles (TCNPs) as an HIV-microbicide. Materials & methods: TCNPs were subjected to various physicochemical characterization experiments, followed by in vitro and in vivo experiments to assess their efficacy. Results: TCNPs had a diameter of 74.31 ± 2.56 nm with a gross encapsulation of more than 61% for each drug. Nanoparticles were effective against HIV-1 replication, with an IC50 of 1.75 μM for curcumin and 2.8 μM for tenofovir. TCNPs provided drug release at the application site for up to 8–12 h, with minimal leakage into the systemic circulation. TCNPs showed spermicidal activity at ≥200 μM and induced minimal cytotoxicity and inflammation in the vaginal epithelium as revealed by histopathological and ELISA studies. Conclusion: We demonstrated that TCNPs could serve as a novel anti-HIV microbicidal agent in rats. [Formula: see text]

Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell–mediated cytotoxicity against neuroblastoma in vitro and in vivo

Cytotherapy ◽  
2015 ◽  
Vol 17 (5) ◽  
pp. 601-612 ◽  
Author(s):  
Antonio Pérez-Martínez ◽  
Jaime Valentín ◽  
Lucía Fernández ◽  
Enrique Hernández-Jiménez ◽  
Eduardo López-Collazo ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Rice Bran ◽  
Killer Cell

Augmentation of natural killer cell activity in vitro and in vivo by sericin-derived oligopeptides

2015 ◽  
Vol 13 (3) ◽  
pp. 249-256 ◽  
Author(s):  
Pornpimon Jantaruk ◽  
Porkaew Promphet ◽  
Manote Sutheerawattananonda ◽  
Duangkamol Kunthalert
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Killer Cell Activity

Effects of Ethanol on Human Natural Killer Cell Activity: In Vitro and Acute, Low-Dose In Vivo Studies

1994 ◽  
Vol 18 (6) ◽  
pp. 1361-1367 ◽  
Author(s):  
Miriam Ochshorn-Adelson ◽  
Gershon Bodner ◽  
Per Toraker ◽  
Henrik Albeck ◽  
Ann Ho ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Low Dose ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
In Vivo Studies ◽  
Human Natural Killer Cell ◽  
Killer Cell Activity

scholarly journals Renal Transplant Immunosuppression Impairs Natural Killer Cell Function In Vitro and In Vivo

PLoS ONE ◽  
2010 ◽  
Vol 5 (10) ◽  
pp. e13294 ◽  
Author(s):  
Olivier Morteau ◽  
Samkeliso Blundell ◽  
Aron Chakera ◽  
Sophia Bennett ◽  
Charita M. Christou ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Function ◽  
Killer Cell ◽  
Natural Killer Cell Function
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