Defective Calcium Binding to Fibrillin-1: Consequence of an N2144S Change for Fibrillin-1 Structure and Function

1999 ◽  
Vol 285 (3) ◽  
pp. 1277-1287 ◽  
Author(s):  
Susan Kettle ◽  
Xuemei Yuan ◽  
Gabrielle Grundy ◽  
Vroni Knott ◽  
A.Kristina Downing ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Structure And Function ◽  
Fibrillin 1 ◽  
And Function

scholarly journals Calsequestrin Distribution, Structure and Function, Its Role in Normal and Pathological Situations and the Effect of Thyroid Hormones

2011 ◽  
pp. 439-452 ◽  
Author(s):  
P. NOVÁK ◽  
T. SOUKUP
Keyword(s):  
Thyroid Hormones ◽  
Calcium Binding ◽  
Skeletal Muscles ◽  
Scientific Community ◽  
Cardiac Tissue ◽  
Structure And Function ◽  
Multiple Roles ◽  
Important Regulator ◽  
Slow Twitch ◽  
And Function

Calsequestrin is the main calcium binding protein of the sarcoplasmic reticulum, serving as an important regulator of Ca2+. In mammalian muscles, it exists as a skeletal isoform found in fast- and slow-twitch skeletal muscles and a cardiac isoform expressed in the heart and slow-twitch muscles. Recently, many excellent reviews that summarised in great detail various aspects of the calsequestrin structure, localisation or function both in skeletal and cardiac muscle have appeared. The present review focuses on skeletal muscle: information on cardiac tissue is given, where differences between both tissues are functionally important. The article reviews the known multiple roles of calsequestrin including pathology in order to introduce this topic to the broader scientific community and to stimulate an interest in this protein. Newly we describe our results on the effect of thyroid hormones on skeletal and cardiac calsequestrin expression and discuss them in the context of available literary data on this topic.

scholarly journals Modification of the Structure and Function of Fibrillin-1 by Homocysteine Suggests a Potential Pathogenetic Mechanism in Homocystinuria

2005 ◽  
Vol 280 (41) ◽  
pp. 34946-34955 ◽  
Author(s):  
Dirk Hubmacher ◽  
Kerstin Tiedemann ◽  
Rainer Bartels ◽  
Jürgen Brinckmann ◽  
Tillman Vollbrandt ◽  
...  
Keyword(s):  
Structure And Function ◽  
Pathogenetic Mechanism ◽  
Fibrillin 1 ◽  
And Function

scholarly journals Structure and function of a novel calcium-binding protein, CaBPc, from cardiac muscle.

1991 ◽  
Vol 55 ◽  
pp. 96
Author(s):  
Michiko Naka ◽  
Toshiya Sasaki ◽  
Hideaki Kise ◽  
Isao Tawara ◽  
Satoshi Hamaguchi ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Calcium Binding ◽  
Binding Protein ◽  
Structure And Function ◽  
Calcium Binding Protein ◽  
And Function

Structure and function of Ca2+-binding EGF-like domains in human fibrillin-1

1997 ◽  
Vol 16 (2) ◽  
pp. 81
Author(s):  
Susan Kettle ◽  
CarolineM. Cardy ◽  
Xuemei Yuan ◽  
A.Kristina Downing ◽  
Penny Handford
Keyword(s):  
Structure And Function ◽  
Fibrillin 1 ◽  
And Function

Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine kinase

2016 ◽  
Vol 18 (12) ◽  
pp. 8673-8681 ◽  
Author(s):  
Chunxia Gao ◽  
Morten Grøtli ◽  
Leif A. Eriksson
Keyword(s):  
Protein Structure ◽  
Tyrosine Kinase ◽  
Calcium Binding ◽  
Structure And Function ◽  
Binding Region ◽  
Protein Structure And Function ◽  
And Function

Changes in the calcium binding region of the cadherin-like domain of RET tyrosine kinase alters protein structure and function.

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