scholarly journals Calsequestrin Distribution, Structure and Function, Its Role in Normal and Pathological Situations and the Effect of Thyroid Hormones

2011 ◽  
pp. 439-452 ◽  
Author(s):  
P. NOVÁK ◽  
T. SOUKUP
Keyword(s):  
Thyroid Hormones ◽  
Calcium Binding ◽  
Skeletal Muscles ◽  
Scientific Community ◽  
Cardiac Tissue ◽  
Structure And Function ◽  
Multiple Roles ◽  
Important Regulator ◽  
Slow Twitch ◽  
And Function

Calsequestrin is the main calcium binding protein of the sarcoplasmic reticulum, serving as an important regulator of Ca2+. In mammalian muscles, it exists as a skeletal isoform found in fast- and slow-twitch skeletal muscles and a cardiac isoform expressed in the heart and slow-twitch muscles. Recently, many excellent reviews that summarised in great detail various aspects of the calsequestrin structure, localisation or function both in skeletal and cardiac muscle have appeared. The present review focuses on skeletal muscle: information on cardiac tissue is given, where differences between both tissues are functionally important. The article reviews the known multiple roles of calsequestrin including pathology in order to introduce this topic to the broader scientific community and to stimulate an interest in this protein. Newly we describe our results on the effect of thyroid hormones on skeletal and cardiac calsequestrin expression and discuss them in the context of available literary data on this topic.

scholarly journals Structure and function of a novel calcium-binding protein, CaBPc, from cardiac muscle.

1991 ◽  
Vol 55 ◽  
pp. 96
Author(s):  
Michiko Naka ◽  
Toshiya Sasaki ◽  
Hideaki Kise ◽  
Isao Tawara ◽  
Satoshi Hamaguchi ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Calcium Binding ◽  
Binding Protein ◽  
Structure And Function ◽  
Calcium Binding Protein ◽  
And Function

scholarly journals Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering

2017 ◽  
Vol 53 (53) ◽  
pp. 7412-7415 ◽  
Author(s):  
Alec S. T. Smith ◽  
Hyok Yoo ◽  
Hyunjung Yi ◽  
Eun Hyun Ahn ◽  
Justin H. Lee ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Nano Scale ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Hybrid Scaffolds

Topographic and graphene-functionalized culture substrates were fabricated to regulate cardiac structure and function through manipulation of micro- and nano-scale mechanical and electroconductive cues.

scholarly journals AGE-RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLES

2007 ◽  
Vol 34 (11) ◽  
pp. 1091-1096 ◽  
Author(s):  
John A Faulkner ◽  
Lisa M Larkin ◽  
Dennis R Claflin ◽  
Susan V Brooks
Keyword(s):  
Skeletal Muscles ◽  
Structure And Function ◽  
Age Related ◽  
And Function ◽  
Age Related Changes

Molecular characterization of rat skeletal muscle myosin light chain kinase

1989 ◽  
Vol 256 (2) ◽  
pp. C399-C404 ◽  
Author(s):  
B. P. Herring ◽  
M. H. Nunnally ◽  
P. J. Gallagher ◽  
J. T. Stull
Keyword(s):  
Skeletal Muscle ◽  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Skeletal Muscles ◽  
Myosin Light Chain ◽  
Cardiac Tissue ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Myosin ◽  
Slow Twitch ◽  
Muscle Myosin

A 1.85-kilobase (kb) cDNA has been isolated that encodes the catalytic and calmodulin binding domains of rat skeletal muscle myosin light chain kinase. The cDNA hybridized to a 3.3-kb RNA present in fast- and slow-twitch skeletal muscles. The reported enzymatic activity (3-fold greater in fast- than slow-twitch skeletal muscles) reflects the relative abundance of this RNA in the two types of skeletal muscle. No hybridization of the cDNA was detected to RNA isolated from smooth or nonmuscle tissues. The clone cross hybridized to a 2.2-kb RNA present in cardiac tissue. Ribonuclease protection analysis of skeletal and cardiac muscle RNA revealed major differences in the two hybridizing RNAs. Thus rat skeletal muscle contains a single myosin light chain kinase isoform, which is distinct from the cardiac, smooth, and nonmuscle forms.

scholarly journals Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs

2009 ◽  
Vol 107 (2) ◽  
pp. 565-570 ◽  
Author(s):  
D.-H. Kim ◽  
E. A. Lipke ◽  
P. Kim ◽  
R. Cheong ◽  
S. Thompson ◽  
...  
Keyword(s):  
Cardiac Tissue ◽  
Structure And Function ◽  
Tissue Constructs ◽  
And Function

Defective Calcium Binding to Fibrillin-1: Consequence of an N2144S Change for Fibrillin-1 Structure and Function

1999 ◽  
Vol 285 (3) ◽  
pp. 1277-1287 ◽  
Author(s):  
Susan Kettle ◽  
Xuemei Yuan ◽  
Gabrielle Grundy ◽  
Vroni Knott ◽  
A.Kristina Downing ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Structure And Function ◽  
Fibrillin 1 ◽  
And Function

scholarly journals Electroactive Polymeric Composites to Mimic the Electromechanical Properties of Myocardium in Cardiac Tissue Repair

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 53
Author(s):  
Kaylee Meyers ◽  
Bruce P. Lee ◽  
Rupak M. Rajachar
Keyword(s):  
Electrical Properties ◽  
Wound Repair ◽  
Cardiac Tissue ◽  
Cell Attachment ◽  
Polymeric Composites ◽  
Scar Tissue ◽  
Structure And Function ◽  
Force Transmission ◽  
Stem Cell Delivery ◽  
And Function

Due to the limited regenerative capabilities of cardiomyocytes, incidents of myocardial infarction can cause permanent damage to native myocardium through the formation of acellular, non-conductive scar tissue during wound repair. The generation of scar tissue in the myocardium compromises the biomechanical and electrical properties of the heart which can lead to further cardiac problems including heart failure. Currently, patients suffering from cardiac failure due to scarring undergo transplantation but limited donor availability and complications (i.e., rejection or infectious pathogens) exclude many individuals from successful transplant. Polymeric tissue engineering scaffolds provide an alternative approach to restore normal myocardium structure and function after damage by acting as a provisional matrix to support cell attachment, infiltration and stem cell delivery. However, issues associated with mechanical property mismatch and the limited electrical conductivity of these constructs when compared to native myocardium reduces their clinical applicability. Therefore, composite polymeric scaffolds with conductive reinforcement components (i.e., metal, carbon, or conductive polymers) provide tunable mechanical and electroactive properties to mimic the structure and function of natural myocardium in force transmission and electrical stimulation. This review summarizes recent advancements in the design, synthesis, and implementation of electroactive polymeric composites to better match the biomechanical and electrical properties of myocardial tissue.

Sign in / Sign up

Export Citation Format

Share Document