Vascular Smooth Muscle Contractile Function Is Impaired during Early and Late Stages of Sepsis

1994 ◽  
Vol 56 (6) ◽  
pp. 556-561 ◽  
Author(s):  
Samuel H. Wurster ◽  
Ping Wang ◽  
Richard E. Dean ◽  
Irshad H. Chaudry
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Contractile Function ◽  
Late Stages ◽  
Muscle Contractile

scholarly journals Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries

2018 ◽  
Vol 9 ◽  
Author(s):  
John W. Seawright ◽  
Harini Sreenivasappa ◽  
Holly C. Gibbs ◽  
Samuel Padgham ◽  
Song Y. Shin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Contractile Function ◽  
Feed Arteries ◽  
Muscle Contractile ◽  
Skeletal Muscle Feed Arteries

scholarly journals Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility

2019 ◽  
Vol 141 (3) ◽  
Author(s):  
Alexander W. Caulk ◽  
Jay D. Humphrey ◽  
Sae-Il Murtada
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Contractile Function ◽  
Contractile Activity ◽  
Comparison Of Methods ◽  
Axial Stretch ◽  
Smooth Muscle Function ◽  
In Vivo Loading

Vascular smooth muscle cells (VSMCs) can regulate arterial mechanics via contractile activity in response to changing mechanical and chemical signals. Contractility is traditionally evaluated via uniaxial isometric testing of isolated rings despite the in vivo environment being very different. Most blood vessels maintain a locally preferred value of in vivo axial stretch while subjected to changes in distending pressure, but both of these phenomena are obscured in uniaxial isometric testing. Few studies have rigorously analyzed the role of in vivo loading conditions in smooth muscle function. Thus, we evaluated effects of uniaxial versus biaxial deformations on smooth muscle contractility by stimulating two regions of the mouse aorta with different vasoconstrictors using one of three testing protocols: (i) uniaxial isometric testing, (ii) biaxial isometric testing, and (iii) axially isometric plus isobaric testing. Comparison of methods (i) and (ii) revealed increased sensitivity and contractile capacity to potassium chloride and phenylephrine (PE) with biaxial isometric testing, and comparison of methods (ii) and (iii) revealed a further increase in contractile capacity with isometric plus isobaric testing. Importantly, regional differences in estimated in vivo axial stretch suggest locally distinct optimal biaxial configurations for achieving maximal smooth muscle contraction, which can only be revealed with biaxial testing. Such differences highlight the importance of considering in vivo loading and geometric configurations when evaluating smooth muscle function. Given the physiologic relevance of axial extension and luminal pressurization, we submit that, when possible, axially isometric plus isobaric testing should be employed to evaluate vascular smooth muscle contractile function.

Subacute Sepsis Impairs Vascular Smooth Muscle Contractile Machinery and Alters Vasoconstrictor and Dilator Mechanisms

1999 ◽  
Vol 83 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Shaun A. Price ◽  
David A. Spain ◽  
Mark A. Wilson ◽  
Patrick D. Harris ◽  
R.Neal Garrison
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Contractile

Role of Sarcoplasmic Reticulum in the Contractile Function of Vascular Smooth Muscle as Studied by 2,5-Di-(Tert-Butyl)-1,4-Benzohydroquinone

Neurosignals ◽  
1992 ◽  
Vol 1 (4) ◽  
pp. 182-193 ◽  
Author(s):  
Hiroyuki Shimamoto ◽  
Ingrid L.A. Majarais ◽  
Yoriko Shimamoto ◽  
Chiu-Yin Kwan ◽  
Edwin E. Daniel
Keyword(s):  
Smooth Muscle ◽  
Sarcoplasmic Reticulum ◽  
Vascular Smooth Muscle ◽  
Contractile Function ◽  
Tert Butyl

Tyrosine phosphorylation is associated with enhanced vascular smooth muscle contractile responses in cardiomyopathic hamsters

1998 ◽  
Vol 4 (3) ◽  
pp. 73
Author(s):  
Atsushi Sato ◽  
Mitsuhiro Fukao ◽  
Ichiro Sakuma ◽  
Yuichi Hattori ◽  
Morio Kanno ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Tyrosine Phosphorylation ◽  
Contractile Responses ◽  
Cardiomyopathic Hamsters ◽  
Muscle Contractile
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