Chitosan and Its Potential Use for the Delivery of Bioactive Molecules in Bone Tissue Engineering

2021 ◽  
pp. 117-162
Author(s):  
D. Saleth Sidharthan ◽  
R. Abhinandan ◽  
S. Pranav Adithya ◽  
K. Balagangadharan ◽  
N. Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bioactive Molecules ◽  
Potential Use

scholarly journals A dual-application poly (dl-lactic-co-glycolic) acid (PLGA)-chitosan composite scaffold for potential use in bone tissue engineering

2017 ◽  
Vol 28 (16) ◽  
pp. 1966-1983 ◽  
Author(s):  
Yamina Boukari ◽  
Omar Qutachi ◽  
David J. Scurr ◽  
Andrew P. Morris ◽  
Stephen W. Doughty ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glycolic Acid ◽  
Composite Scaffold ◽  
Chitosan Composite ◽  
Potential Use

Anionic diketopiperazine induces osteogenic differentiation and supports osteogenesis in a 3D cryogel microenvironment

2021 ◽  
Author(s):  
Apurva Panjla ◽  
Irfan Qayoom ◽  
Ashok Kumar ◽  
Sandeep Verma
Keyword(s):  
Tissue Engineering ◽  
Amino Acid ◽  
Bone Tissue Engineering ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Precursor Cells ◽  
Bioactive Molecules ◽  
Osteogenic Potential

Bioactive molecules that enhance or induce osteogenic potential of bone precursor cells have shown vital roles in bone tissue engineering. Herein, we report a novel diketopiperazine, containing taurine amino acid,...

scholarly journals The potential use of thermosensitive chitosan/silk sericin hydrogels loaded with longan seed extract for bone tissue engineering

RSC Advances ◽  
2018 ◽  
Vol 8 (70) ◽  
pp. 40219-40231 ◽  
Author(s):  
Porntipa Pankongadisak ◽  
Orawan Suwantong
Keyword(s):  
Tissue Engineering ◽  
Body Temperature ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Seed Extract ◽  
Silk Sericin ◽  
Longan Seed ◽  
Potential Use

In this study, hydrogels that were thermosensitive at body temperature were developed using chitosan (CS)/silk sericin (SS)/β-glycerophosphate (β-GP) loaded with longan seed extract (LE) for use in bone tissue engineering.

Physicomechanical properties of sintered scaffolds formed from porous and protein-loaded poly(DL-lactic-co-glycolic acid) microspheres for potential use in bone tissue engineering

2015 ◽  
Vol 26 (12) ◽  
pp. 796-811 ◽  
Author(s):  
Yamina Boukari ◽  
David J. Scurr ◽  
Omar Qutachi ◽  
Andrew P. Morris ◽  
Stephen W. Doughty ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glycolic Acid ◽  
Physicomechanical Properties ◽  
Potential Use

scholarly journals MiRNA- Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1472
Author(s):  
Davood Kharaghani ◽  
Eben Bashir Kurniwan ◽  
Muhammad Qamar Khan ◽  
Yuji Yoshiko
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Development ◽  
Bioactive Molecules ◽  
Fibrous Scaffold ◽  
Bioactive Scaffolds ◽  
Alternative Treatment Option ◽  
The Impact

Scaffold-based bone tissue engineering has been introduced as an alternative treatment option for bone grafting due to limitations in the allograft. Not only physical conditions but also biological conditions such as gene expression significantly impact bone regeneration. Scaffolds in composition with bioactive molecules such as miRNA mimics provide a platform to enhance migration, proliferation, and differentiation of osteoprogenitor cells for bone regeneration. Among scaffolds, fibrous structures showed significant advantages in promoting osteogenic differentiation and bone regeneration via delivering bioactive molecules over the past decade. Here, we reviewed the bone and bone fracture healing considerations for the impact of miRNAs on bone regeneration. We also examined the methods used to improve miRNA mimics uptake by cells, the fabrication of fibrous scaffolds, and the effective delivery of miRNA mimics using fibrous scaffold and their processes for bone development. Finally, we offer our view on the principal challenges of miRNA mimics delivery by nanofibers for bone tissue engineering.

scholarly journals Formulation of silver chloride/poly(3-hydroxybutyrate-co -3-hydroxyvalerate) (AgCl/PHBV) films for potential use in bone tissue engineering

2017 ◽  
Vol 134 (31) ◽  
pp. 45162 ◽  
Author(s):  
Rotimi Bakare ◽  
Lauren Wells ◽  
Negene McLennon ◽  
Manisha Singh ◽  
Ayele Gugssa ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silver Chloride ◽  
Potential Use

scholarly journals Biomineralization of Natural Collagenous Nanofibrous Membranes and Their Potential Use in Bone Tissue Engineering

2015 ◽  
Vol 11 (3) ◽  
pp. 447-456 ◽  
Author(s):  
Mingying Yang ◽  
Guanshan Zhou ◽  
Harold Castano-Izquierdo ◽  
Ye Zhu ◽  
Chuanbin Mao
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nanofibrous Membranes ◽  
Potential Use

An introduction to bone tissue engineering

2019 ◽  
Vol 43 (2) ◽  
pp. 69-86 ◽  
Author(s):  
Željka Perić Kačarević ◽  
Patrick Rider ◽  
Said Alkildani ◽  
Sujith Retnasingh ◽  
Marija Pejakić ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Structure ◽  
Tissue Scaffolds ◽  
Pathogen Transmission ◽  
The Body ◽  
Bioactive Molecules ◽  
Advantages And Disadvantages ◽  
Degradation Rates

Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor site morbidity or the risk of pathogen transmission. The development of bone tissue engineering has been used to create functional alternatives to regenerate bone. This can be achieved by producing bone tissue scaffolds that induce osteoconduction and integration, provide mechanical stability, and either integrate into the bone structure or degrade and are excreted by the body. A range of different biomaterials have been used to this end, each with their own advantages and disadvantages. This review will introduce the requirements of bone tissue engineering, beginning with the regeneration process of bone before exploring the requirements of bone tissue scaffolds. Aspects covered include the manufacturing process as well as the different materials used and the incorporation of bioactive molecules, growth factors and cells.

scholarly journals An update on the Application of Nanotechnology in Bone Tissue Engineering

2016 ◽  
Vol 10 (1) ◽  
pp. 836-848 ◽  
Author(s):  
MF Griffin ◽  
DM Kalaskar ◽  
A. Seifalian ◽  
PE Butler
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Structure ◽  
Bioactive Molecules ◽  
Bone Tissue Regeneration ◽  
Native Bone ◽  
Natural Bone ◽  
Nanofibrous Scaffolds

Background:Natural bone is a complex and hierarchical structure. Bone possesses an extracellular matrix that has a precise nano-sized environment to encourage osteoblasts to lay down bone by directing them through physical and chemical cues. For bone tissue regeneration, it is crucial for the scaffolds to mimic the native bone structure. Nanomaterials, with features on the nanoscale have shown the ability to provide the appropriate matrix environment to guide cell adhesion, migration and differentiation.Methods:This review summarises the new developments in bone tissue engineering using nanobiomaterials. The design and selection of fabrication methods and biomaterial types for bone tissue engineering will be reviewed. The interactions of cells with different nanostructured scaffolds will be discussed including nanocomposites, nanofibres and nanoparticles.Results:Several composite nanomaterials have been able to mimic the architecture of natural bone. Bioceramics biomaterials have shown to be very useful biomaterials for bone tissue engineering as they have osteoconductive and osteoinductive properties. Nanofibrous scaffolds have the ability to provide the appropriate matrix environment as they can mimic the extracellular matrix structure of bone. Nanoparticles have been used to deliver bioactive molecules and label and track stem cells.Conclusion:Future studies to improve the application of nanomaterials for bone tissue engineering are needed.

scholarly journals Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhuowen Hao ◽  
Zhenhua Xu ◽  
Xuan Wang ◽  
Yi Wang ◽  
Hanke Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Defects ◽  
Bioactive Molecules ◽  
Mechanical Stimuli ◽  
Future Perspectives ◽  
Biomaterial Scaffolds ◽  
Critical Bone Defects

The repair of critical bone defects remains challenging worldwide. Three canonical pillars (biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have been widely used for bone regeneration in separate or combined strategies, but the delivery of bioactive molecules has several obvious drawbacks. Biophysical stimuli have great potential to become the fourth pillar of bone tissue engineering, which can be categorized into three groups depending on their physical properties: internal structural stimuli, external mechanical stimuli, and electromagnetic stimuli. In this review, distinctive biophysical stimuli coupled with their osteoinductive windows or parameters are initially presented to induce the osteogenesis of mesenchymal stem cells (MSCs). Then, osteoinductive mechanisms of biophysical transduction (a combination of mechanotransduction and electrocoupling) are reviewed to direct the osteogenic differentiation of MSCs. These mechanisms include biophysical sensing, transmission, and regulation. Furthermore, distinctive application strategies of biophysical stimuli are presented for bone tissue engineering, including predesigned biomaterials, tissue-engineered bone grafts, and postoperative biophysical stimuli loading strategies. Finally, ongoing challenges and future perspectives are discussed.

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