Intracellular Trafficking of Gonadotropin Receptors in Health and Disease

2017 ◽  
pp. 1-39 ◽  
Author(s):  
Alfredo Ulloa-Aguirre ◽  
Teresa Zariñán ◽  
Rubén Gutiérrez-Sagal ◽  
James A. Dias
Keyword(s):  
Intracellular Trafficking ◽  
Gonadotropin Receptors ◽  
Health And Disease

The role of LRRK2 in cytoskeletal dynamics

2018 ◽  
Vol 46 (6) ◽  
pp. 1653-1663 ◽  
Author(s):  
Laura Civiero ◽  
Susanna Cogo ◽  
Alice Biosa ◽  
Elisa Greggio
Keyword(s):  
Intracellular Trafficking ◽  
Vesicle Transport ◽  
Brain Cells ◽  
Leucine Rich Repeat ◽  
Growth And Remodeling ◽  
Long Distance ◽  
Cytoskeletal Dynamics ◽  
Neuronal Processes ◽  
Health And Disease

Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-distance vesicle transport, synaptic plasticity, and dendrites/axons growth and remodeling. Here, we will review the available data linking LRRK2 and the cytoskeleton, and discuss how this may be functionally relevant for the well-established roles of LRRK2 in intracellular trafficking pathways and outgrowth of neuronal processes in health and disease conditions.

Drug Induced Changes in Cell Organelles

1968 ◽  
Vol 26 ◽  
pp. 110-111
Author(s):  
Sarah A. Luse
Keyword(s):  
Clinical Medicine ◽  
Cell Organelles ◽  
Riboflavin Deficiency ◽  
Drug Induced ◽  
New Era ◽  
Health And Disease ◽  
In The Beginning ◽  
Cellular Pathology ◽  
Induced Changes ◽  
The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

The Laryngeal Epithelium in Reflux

2011 ◽  
Vol 21 (3) ◽  
pp. 112-117 ◽  
Author(s):  
Elizabeth Erickson-Levendoski ◽  
Mahalakshmi Sivasankar
Keyword(s):  
Laryngopharyngeal Reflux ◽  
Critical Role ◽  
Structure And Function ◽  
Laryngeal Disease ◽  
Health And Disease ◽  
And Function ◽  
The Impact

The epithelium plays a critical role in the maintenance of laryngeal health. This is evident in that laryngeal disease may result when the integrity of the epithelium is compromised by insults such as laryngopharyngeal reflux. In this article, we will review the structure and function of the laryngeal epithelium and summarize the impact of laryngopharyngeal reflux on the epithelium. Research investigating the ramifications of reflux on the epithelium has improved our understanding of laryngeal disease associated with laryngopharyngeal reflux. It further highlights the need for continued research on the laryngeal epithelium in health and disease.

Studies on Gastric Mucus in Health and Disease

1965 ◽  
Vol 48 (6) ◽  
pp. 758-767 ◽  
Author(s):  
Lansing C. Hoskins ◽  
Norman Zamcheck
Keyword(s):  
Gastric Mucus ◽  
Health And Disease

A Method for the Colorimetric Determination of β-Glucuronidase in Urine, Serum, Tissue; Assay of Enzymatic Activity in Health and Disease

1959 ◽  
Vol 36 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Julius A. Goldbarg ◽  
Esteban P. Pineda ◽  
Benjamin M. Banks ◽  
Alexander M. Rutenburg
Keyword(s):  
Enzymatic Activity ◽  
Colorimetric Determination ◽  
Health And Disease ◽  
Urine Serum

Human sperm contains luteinizing hormone and chorionic gonadotropin receptors

1998 ◽  
Vol 5 (1) ◽  
pp. 107A-107A
Author(s):  
A EBLEN ◽  
S BAO ◽  
Z LEI ◽  
J SANFILIPPO ◽  
C RAO
Keyword(s):  
Luteinizing Hormone ◽  
Chorionic Gonadotropin ◽  
Human Sperm ◽  
Gonadotropin Receptors
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