Cutaneous Barriers and Skin Immunity

Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in Vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease. This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome.

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Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity

The Journal of Cell Biology ◽

10.1083/jcb.200501071 ◽

2005 ◽

Vol 169 (4) ◽

pp. 569-576 ◽

Cited By ~ 326

Author(s):

Clare L. Bennett ◽

Erwin van Rijn ◽

Steffen Jung ◽

Kayo Inaba ◽

Ralph M. Steinman ◽

...

Keyword(s):

Dendritic Cells ◽

Steady State ◽

Diphtheria Toxin ◽

Langerhans Cells ◽

Contact Hypersensitivity ◽

Relative Importance ◽

Skin Immunity

Langerhans cells (LC) form a unique subset of dendritic cells (DC) in the epidermis but so far their in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC (dDC). Here, we exploit a novel diphtheria toxin (DT) receptor (DTR)/DT-based system to achieve inducible ablation of LC without affecting the skin environment. Within 24 h after intra-peritoneal injection of DT into Langerin-DTR mice LC are completely depleted from the epidermis and only begin to return 4 wk later. LC deletion occurs by apoptosis in the absence of inflammation and, in particular, the dDC compartment is not affected. In LC-depleted mice contact hypersensitivity (CHS) responses are significantly decreased, although ear swelling still occurs indicating that dDC can mediate CHS when necessary. Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance.

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PENGGUNAAN TABIR SURYA BAGI KESEHATAN KULIT

JURNAL PENDIDIKAN DAN KELUARGA ◽

10.24036/jpk/vol11-iss1/619 ◽

2019 ◽

Vol 11 (1) ◽

pp. 87

Author(s):

Prima Minerva

Keyword(s):

Skin Cancer ◽

Adverse Effects ◽

Uv Light ◽

Light Exposure ◽

Premature Aging ◽

Negative Effects ◽

Physical Protection ◽

Skin Immunity ◽

Long Time ◽

The Right

Most activities are done outside the home often make the skin exposed to UV light. Exposure UV light excessively or in a long time can cause the occurrence of skin disorders such as Sunburn, premature aging, lowering skin immunity to skin cancer. In preventing the negative effects of UV light on the skin, various ways can be done such as by using a protector such as clothes, hats, glasses or umbrellas. But this physical protection is not sufficient because of the UV light penetrating power. Sunscreen is a skin care cosmetic that provides physical protection against UV light. Proper use of sunscreen and routine can protect the skin from the negative effects of UV light. This paper describes the effects of UV light on the skin, the function of sunscreen and the right use and compatible types sunscreen in maintaining skin health from the adverse effects of UV light.

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Skin immunity

British Journal of Dermatology ◽

10.1046/j.0366-077x.2003.05624.x ◽

2003 ◽

Vol 149 (s66) ◽

pp. 2-4 ◽

Cited By ~ 11

Author(s):

T. Schwarz

Keyword(s):

Skin Immunity

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Mast Cells: Sentinels of Innate Skin Immunity

Clinical and Basic Immunodermatology ◽

10.1007/978-3-319-29785-9_5 ◽

2017 ◽

pp. 67-80

Author(s):

Nicholas Mascarenhas ◽

Zhenping Wang ◽

Anna Di Nardo

Keyword(s):

Mast Cells ◽

Skin Immunity

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PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

Cell Reports ◽

10.1016/j.celrep.2020.108258 ◽

2020 ◽

Vol 33 (2) ◽

pp. 108258

Author(s):

Erin D. Lucas ◽

Johnathon B. Schafer ◽

Jennifer Matsuda ◽

Madison Kraus ◽

Matthew A. Burchill ◽

...

Keyword(s):

Dendritic Cells ◽

Cell Migration ◽

Dendritic Cell ◽

Reverse Signaling ◽

Skin Immunity ◽

Dendritic Cell Migration

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Who is really in control of skin immunity underphysiologicalcircumstances - lymphocytes, dendritic cells or keratinocytes?

Experimental Dermatology ◽

10.1111/j.1600-0625.2006.00506.x ◽

2006 ◽

Vol 15 (11) ◽

pp. 913-929 ◽

Cited By ~ 20

Author(s):

Ralf Paus ◽

J. M. Schröder ◽

K. Reich ◽

K. Kabashima ◽

F. T. Liu ◽

...

Keyword(s):

Dendritic Cells ◽

Skin Immunity

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Ultraviolet Protection by Beach Shade

Volume 3: Pipeline and Riser Technology; Ocean Space Utilization ◽

10.1115/omae2008-57287 ◽

2008 ◽

Author(s):

Toshimasa Kawanishi ◽

Yuko Sueda

Keyword(s):

Skin Cancer ◽

Ultraviolet Radiation ◽

Human Body ◽

Health Problem ◽

Radiation Spectrum ◽

Know How ◽

Skin Immunity ◽

Ultraviolet Protection ◽

Radiance Distribution ◽

Uv C

Ultraviolet radiation is divided into UV-A (320–400nm), UV-B (290–320nm), UV-C (under 290nm). Of these, UV-B may be cause serious health problem, such as cataracts, loss of skin immunity, and increase of skin cancer. For this reason, it is important to know how to protect human body against the UV-B radiation. Beach shade is very effective to prevent the radiation. The radiation enters to the shade from sun and sky. The first step is to measure the sky radiance distribution of sun and sky radiation spectrum. We calculate erythema action radiation from the radiation spectrum. Sunburn chart is made using distribution of the erythema action ultraviolet radiation. Using the Sunburn chart, the shade is designed for protect against the UV radiation.

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