Murine Models of Atopic Dermatitis

2006 ◽  
pp. 133-166 ◽  
Author(s):  
T. Brzoska ◽  
T. A. Luger
Keyword(s):  
Atopic Dermatitis ◽  
Murine Models

Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis

2017 ◽  
pp. 233-262
Author(s):  
Kristine Roßbach ◽  
Hanna Köchling ◽  
Tomoki Fukuyama ◽  
Jenny Wilzopolski ◽  
Manfred Kietzmann ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Histamine Receptor ◽  
Murine Models ◽  
Receptor Antagonists ◽  
Histamine Receptor Antagonists

DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models

2009 ◽  
Vol 124 (1) ◽  
pp. 90-99 ◽  
Author(s):  
Asuka Hamasaka ◽  
Riichiro Abe ◽  
Yoshikazu Koyama ◽  
Naoya Yoshioka ◽  
Yasuyuki Fujita ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Dna Vaccination ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Murine Models

Stellera chamaejasme and Its Main Compound Luteolin 7-O-Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis

Planta Medica ◽  
2018 ◽  
Vol 85 (07) ◽  
pp. 583-590 ◽  
Author(s):  
Beom-Geun Jo ◽  
No-June Park ◽  
Jonghwan Jegal ◽  
Sangho Choi ◽  
Sang Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Histopathological Examination ◽  
Skin Lesions ◽  
Transepidermal Water Loss ◽  
Murine Models ◽  
Hairless Mice ◽  
Main Compound ◽  
Etoh Extract ◽  
Aerial Parts ◽  
Stellera Chamaejasme

Abstract Stellera chamaejasme, also known as “Langdu”, has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Atopic skin symptoms, including erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening), responded to treatment with S. chamaejasme aerial parts EtOH extract for 2 or 3 weeks. Histopathological examination revealed S. chamaejasme aerial parts EtOH extract significantly reduced inflammatory cell infiltration when applied to atopic dermatitis mice. In addition, luteolin 7-O-glucoside, the major active compound of the S. chamaejasme aerial parts EtOH extract, decreased serum IgE and IL-4 levels and transepidermal water loss and increased skin hydration, therefore exhibiting strong anti-atopic dermatitis activity in 2,4-dinitrochlorobenzene-induced atopic dermatitis mice. In this study, we confirmed antipruritic and antidermatitic effects of S. chamaejasme extract and its main component luteolin 7-O-glucoside in atopic dermatitis murine models. The study shows S. chamaejasme aerial parts EtOH extract and luteolin 7-O-glucoside are most likely to be potential drug candidates for atopic dermatitis treatment.

scholarly journals Transcriptomic insight into the translational value of two murine models in human atopic dermatitis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Young-Won Kim ◽  
Eun-A Ko ◽  
Sung-Cherl Jung ◽  
Donghee Lee ◽  
Yelim Seo ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Predictive Accuracy ◽  
Gene Signature ◽  
Skin Condition ◽  
Gene Expression Omnibus ◽  
Contact Hypersensitivity ◽  
Differentially Expressed ◽  
Murine Models ◽  
Transcriptome Data ◽  
Preclinical Research

AbstractThis study sought to develop a novel diagnostic tool for atopic dermatitis (AD). Mouse transcriptome data were obtained via RNA-sequencing of dorsal skin tissues of CBA/J mice affected with contact hypersensitivity (induced by treatment with 1-chloro-2,4-dinitrobenzene) or brush stimulation-induced AD-like skin condition. Human transcriptome data were collected from German, Swedish, and American cohorts of AD patients from the Gene Expression Omnibus database. edgeR and SAM algorithms were used to analyze differentially expressed murine and human genes, respectively. The FAIME algorithm was then employed to assign pathway scores based on KEGG pathway database annotations. Numerous genes and pathways demonstrated similar dysregulation patterns in both the murine models and human AD. Upon integrating transcriptome information from both murine and human data, we identified 36 commonly dysregulated differentially expressed genes, which were designated as a 36-gene signature. A severity score (AD index) was applied to each human sample to assess the predictive power of the 36-gene AD signature. The diagnostic power and predictive accuracy of this signature were demonstrated for both AD severity and treatment outcomes in patients with AD. This genetic signature is expected to improve both AD diagnosis and targeted preclinical research.

Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis

2019 ◽  
Vol 95 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Hyeon-Cheol Lee ◽  
Mitsutoshi Tominaga ◽  
Ken Yasukawa ◽  
Mai Ohba ◽  
Nobuaki Takahashi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Fatty Acid ◽  
Eicosapentaenoic Acid ◽  
Dietary Supplementation ◽  
Murine Models ◽  
Omega 3 ◽  
Omega 3 Fatty Acid

scholarly journals A Probiotic Preparation Alleviates Atopic Dermatitis-Like Skin Lesions in Murine Models

2016 ◽  
Vol 32 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Min-Soo Kim ◽  
Jin-Eung Kim ◽  
Yeo-Sang Yoon ◽  
Jae-Gu Seo ◽  
Myung-Jun Chung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Lesions ◽  
Murine Models ◽  
Probiotic Preparation

Core-Multishell-Nanocarriers, Potential Drug Transporters, have no Impact on Atopic Dermatitis or Psoriasis in Murine Models

2016 ◽  
Vol 154 (1) ◽  
pp. 73
Author(s):  
H. Pischon ◽  
M. Radbruch ◽  
A. Ostrowski ◽  
M. Unbehauen ◽  
R. Haag ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Drug Transporters ◽  
Potential Drug ◽  
Murine Models

scholarly journals Diosmetin and Its Glycoside, Diosmin, Improve Atopic Dermatitis- Like Lesions in 2,4-Dinitrochlorobenzene-Induced Murine Models

2020 ◽  
Vol 28 (6) ◽  
pp. 542-548
Author(s):  
Sang-a Park ◽  
Sim-Kyu Bong ◽  
Jin Woo Lee ◽  
No-June Park ◽  
Yongsoo Choi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Murine Models
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