Conceptualizing and Assessing Everyday Functioning in the Context of HIV-Associated Neurocognitive Disorders

2019 ◽  
Author(s):  
Victoria M. Kordovski ◽  
Savanna M. Tierney ◽  
Steven Paul Woods
2011 ◽  
Vol 17 (4) ◽  
pp. 740-745 ◽  
Author(s):  
J. Cobb Scott ◽  
Steven Paul Woods ◽  
Ofilio Vigil ◽  
Robert K. Heaton ◽  
Igor Grant ◽  
...  

AbstractScript generation describes one's ability to produce complex, sequential action plans derived from mental representations of everyday activities. The aim of this study was to assess the effect of human immunodeficiency virus (HIV) infection on script generation performance. Sixty HIV+ individuals (48% of whom had HIV-associated neurocognitive disorders [HAND]) and 26 demographically comparable HIV- participants were administered a novel, standardized test of script generation, which required participants to verbally generate and organize the necessary steps for completing six daily activities. HAND participants evidenced significantly more total errors, intrusions, and script boundary errors compared to the HIV- sample, indicating difficulties inhibiting irrelevant actions and staying within the prescribed boundaries of scripts, but had adequate knowledge of the relevant actions required for each script. These findings are generally consistent with the executive dysfunction and slowing common in HAND and suggest that script generation may play a role in everyday functioning problems in HIV. (JINS, 2011, 17, 740–745)


2011 ◽  
Vol 18 (1) ◽  
pp. 79-88 ◽  
Author(s):  
K. Blackstone ◽  
D.J. Moore ◽  
R.K. Heaton ◽  
D.R. Franklin ◽  
S.P. Woods ◽  
...  

AbstractThree types of HIV-associated neurocognitive disorders (HAND) exist that are distinguished by presence and severity of impairment in cognitive and everyday functioning. Although well-validated neurocognitive measures exist, determining impairment in everyday functioning remains a challenge. We aim to determine whether Self-Report measures of everyday functioning are as effective in characterizing HAND as Performance-Based measures. We assessed 674 HIV-infected participants with a comprehensive neurocognitive battery; 233 met criteria for a HAND diagnosis by having at least mild neurocognitive impairment. Functional decline was measured via Self-Report and Performance-Based measures. HAND diagnoses were determined according to published criteria using three approaches to assess functional decline: (1) Self-Report measures only, (2) Performance-Based measures only, and (3) Dual-method combining Self-Report and Performance-Based measures. The Dual-method classified the most symptomatic HAND, compared to either singular method. Singular method classifications were 76% concordant with each other. Participants classified as Performance-Based functionally impaired were more likely to be unemployed and more immunosuppressed, whereas those classified as Self-Report functionally impaired had more depressive symptoms. Multimodal methods of assessing everyday functioning facilitate detection of symptomatic HAND. Singular Performance-Based classifications were associated with objective functional and disease-related factors; reliance on Self-Report classifications may be biased by depressive symptoms. (JINS, 2012, 18, 79–88)


2020 ◽  
Author(s):  
Jennifer L. Thompson ◽  
Ilex Beltran-Najera ◽  
Briana Johnson ◽  
Yenifer Morales ◽  
Steven Paul Woods

Objective: Black Americans are at high risk for HIV disease and associated morbidity. However, we know little about the neuropsychological impact and correlates of HIV disease among Black Americans. Methods: Participants included 40 Black persons with HIV (PWH), 83 White PWH, 28 Black HIV- and 64 White HIV- individuals. Neurocognition was measured with raw, sample-based z-scores from a clinical battery. Everyday functioning was assessed using self- and clinician-rated measures of cognitive symptoms and activities of daily living. HIV-associated neurocognitive disorders were classified using the Frascati criteria. Results: We observed a significant three-way interaction between HIV, race, and domain on neurocognitive z-scores. This omnibus effect was driven by large effect size decrements in semantic memory and processing speed in Black PWH compared to the other groups. Black PWH participants also demonstrated higher frequencies of HIV-associated neurocognitive disorders as compared to White PWH. Unexpectedly, global neurocognition was negatively related to everyday functioning for White PWH, but not for Black PWH. Conclusions: Systemic disadvantages for Black Americans may combine with HIV disease to compound some neurocognitive impairments in this vulnerable population. Prospective studies are needed to identify better ways to prevent and manage HIV-associated neurocognitive disorders among Black Americans.


2017 ◽  
Vol 21 (7) ◽  
pp. 2124-2134 ◽  
Author(s):  
Talia N. Shirazi ◽  
Angela C. Summers ◽  
Bryan R. Smith ◽  
Sally R. Steinbach ◽  
Suad Kapetanovic ◽  
...  

2017 ◽  
Vol 23 (7) ◽  
pp. 605-615 ◽  
Author(s):  
Steven Paul Woods ◽  
Jennifer E. Iudicello ◽  
Erin E. Morgan ◽  
Marizela Verduzco ◽  
Tyler V. Smith ◽  
...  

AbstractObjectives: The Internet is a fundamental tool for completing many different instrumental activities of daily living (IADL), including shopping and banking. Persons with HIV−associated Neurocognitive Disorders (HAND) are at heightened risk for IADL problems, but the extent to which HAND interferes with the performance of Internet-based household IADLs is not known. Methods: Ninety-three individuals with HIV disease, 43 of whom were diagnosed with HAND, and 42 HIV− comparison participants completed Internet-based tests of shopping and banking. Participants used mock credentials to log in to an experimenter-controlled Web site and independently performed a series of typical online shopping (e.g., purchasing household goods) and banking (e.g., transferring funds between accounts) tasks. Results: Individuals with HAND were significantly more likely to fail the online shopping task than neurocognitively normal HIV+ and HIV− participants. HAND was also associated with poorer overall performance versus HIV+ normals on the online banking task. In the HAND group, Internet-based task scores were correlated with episodic memory, executive functions, motor skills, and numeracy. In the HIV+ sample as a whole, lower Internet-based task scores were uniquely associated with poorer performance-based functional capacity and self-reported declines in shopping and financial management in daily life, but not with global manifest functional status. Conclusions: Findings indicate that HAND is associated with difficulties in using the Internet to complete important household everyday functioning tasks. The development and validation of effective Internet training and compensatory strategies may help to improve the household management of persons with HAND. (JINS, 2017, 23, 605–615)


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