Pharmacological Prevention of Arrhythmic Recurrences

2006 ◽  
pp. 99-106
Author(s):  
G. Chiaranda ◽  
M.L. Cavarra ◽  
C.L. Romeo ◽  
M. Chiaranda ◽  
T. Regolo
Keyword(s):  
Pharmacological Prevention

Osteoporose und Frakturrisiko beim älteren Sportler: Aktuelle Guidelines

2014 ◽  
Vol 62 (4) ◽  
Keyword(s):  
Fragility Fracture ◽  
Elderly Person ◽  
Vitamin D Supplementation ◽  
Risk Scores ◽  
Human Beings ◽  
Off Label Use ◽  
Risk Of Falling ◽  
Treatment Of Osteoporosis ◽  
Pharmacological Prevention ◽  
Age Related

A Fragility Fracture is nowadays looked upon to be the most important clinical symptom of osteoporosis. The sportive elderly have a limited risk to suffer from this event. Mechanical loading of the skeleton which is associated with most sporty activities prevents age related bone loss. Furthermore, if a fracture happens as a result from sporty activity, the criterion of a fragility fracture is usually not met. Elderly sportsmen who want to be reassured or who are going to restart activity after a break can be offered a fracture risk calculation by means of FRAX. Correct interpretation of the risk scores needs knowledge of the boundary conditions the algorithm is based on. In contrast a DEXA scan is rarely indicated in this situation. Vitamin D Supplementation can generally be adviced for every elderly person in our region, especially for the sportive ones. Sufficient intake of calcium and protein shall be achieved by a healthy diet. Despite of the risk of falling that is usually associated with any sportive activity it may be summarized, that there is less fractures in active people. As long as human beings stay mobile and active, pharmacological prevention or treatment of osteoporosis is rarely indicated. An exeption from this is osteoanabolic treatment of insufficiency and stress fractures. This shall be mentioned here even though it is an “off-label” use of the drugs.

scholarly journals A known unknown? Pharmacological prevention of venous thromboembolism in nursing home residents

2021 ◽  
Author(s):  
Renée A. G. Brüggemann ◽  
Teba Alnima ◽  
Steffie H. A. Brouns ◽  
Nordin M. J. Hanssen ◽  
Jos M. G. A. Schols ◽  
...  
Keyword(s):  
Nursing Home ◽  
Venous Thromboembolism ◽  
Nursing Home Residents ◽  
Pharmacological Prevention

scholarly journals The quality of guidelines in non-pharmacological prevention and management of chemotherapy-induced neuropathy: A review

2018 ◽  
Author(s):  
Shahin Salarvand ◽  
Simin Hemati ◽  
Payman Adibi ◽  
Fariba Taleghani
Keyword(s):  
Methodological Quality ◽  
Stakeholder Involvement ◽  
Common Adverse Effect ◽  
Adaptation Process ◽  
Medical Sciences ◽  
High Quality ◽  
Agree Ii ◽  
Pharmacological Prevention ◽  
Agree Ii Instrument

Chemotherapy-induced peripheral neuropathy is a common adverse effect occurring in patients undergoing neurotoxic chemotherapy. However, there is no FDA-approved treatment option for it. Given the importance of clinical practice guidelines in this area, this study aimed to determine the methodological quality of extant CIPN guidelines. The study was done as part of the adaptation process of CIPN related CPGs at Isfahan University of Medical Sciences, Iran. A systematic search of published CPGs about chemotherapy-induced CIPN in which the AGREE II instrument was applied for appraising CPGs of CIPN was performed. In general, amongst all of the AGREE II Instrument’s domains in the evaluated CPGs, the clarity of presentation and stakeholder involvement domains took favorable scores; and other domains obtained unfavorable and relatively favorable scores. The quality of cancer therapy-induced neuropathy CPGs needs to be improved and designing high-quality CPGs must be considered.

Topical transdermal chemoprevention of breast cancer: where will nanomedical approaches deliver us?

Nanomedicine ◽  
2021 ◽  
Author(s):  
Gabriela Mojeiko ◽  
Julia Sapienza Passos ◽  
Alexsandra Conceição Apolinário ◽  
Luciana Biagini Lopes
Keyword(s):  
Breast Cancer ◽  
Drug Repurposing ◽  
Preventive Therapy ◽  
Mammary Tissue ◽  
High Risk Population ◽  
Prevention Strategies ◽  
New Agents ◽  
Pharmacological Prevention ◽  
High Incidence ◽  
Transdermal Route

Despite the high incidence of breast cancer, there are few pharmacological prevention strategies for the high-risk population and those that are available have low adherence. Strategies that deliver drugs directly to the breasts may increase drug local concentrations, improving efficacy, safety and acceptance. The skin of the breast has been proposed as an administration route for local transdermal therapy, which may improve drug levels in the mammary tissue, due to both deep local penetration and percutaneous absorption. In this review, we discuss the application of nanotechnology-based strategies for the delivery of well established and new agents as well as drug repurposing using the topical transdermal route to improve the outcomes of preventive therapy for breast cancer.

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