Noninvasive Measurement of the Electrical Properties of Breast Epithelium During the Menstrual Cycle: A Potential Biomarker for Breast Cancer Risk

2008 ◽  
pp. 297-304 ◽  
Author(s):  
Richard J. Davies ◽  
Mary K. Brumfield ◽  
Maribeth Pierce
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Electrical Properties ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Noninvasive Measurement ◽  
Breast Epithelium ◽  
Potential Biomarker

scholarly journals DNA Methylation in Benign Breast Epithelium in Relation to Age and Breast Cancer Risk

2008 ◽  
Vol 17 (5) ◽  
pp. 1051-1059 ◽  
Author(s):  
David M. Euhus ◽  
Dawei Bu ◽  
Sara Milchgrub ◽  
Xian-Jin Xie ◽  
Aihua Bian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Epithelium

scholarly journals DNA Methylation and Breast Cancer Risk: An Epigenome-Wide Study of Normal Breast Tissue and Blood

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3088 ◽  
Author(s):  
Kaoutar Ennour-Idrissi ◽  
Dzevka Dragic ◽  
Elissar Issa ◽  
Annick Michaud ◽  
Sue-Ling Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Breast Epithelium ◽  
Normal Breast Epithelium ◽  
Differentially Methylated Genes

Differential DNA methylation is a potential marker of breast cancer risk. Few studies have investigated DNA methylation changes in normal breast tissue and were largely confounded by cancer field effects. To detect methylation changes in normal breast epithelium that are causally associated with breast cancer occurrence, we used a nested case–control study design based on a prospective cohort of patients diagnosed with a primary invasive hormone receptor-positive breast cancer. Twenty patients diagnosed with a contralateral breast cancer (CBC) were matched (1:1) with 20 patients who did not develop a CBC on relevant risk factors. Differentially methylated Cytosine-phosphate-Guanines (CpGs) and regions in normal breast epithelium were identified using an epigenome-wide DNA methylation assay and robust linear regressions. Analyses were replicated in two independent sets of normal breast tissue and blood. We identified 7315 CpGs (FDR < 0.05), 52 passing strict Bonferroni correction (p < 1.22 × 10−7) and 43 mapping to known genes involved in metabolic diseases with significant enrichment (p < 0.01) of pathways involving fatty acids metabolic processes. Four differentially methylated genes were detected in both site-specific and regions analyses (LHX2, TFAP2B, JAKMIP1, SEPT9), and three genes overlapped all three datasets (POM121L2, KCNQ1, CLEC4C). Once validated, the seven differentially methylated genes distinguishing women who developed and who did not develop a sporadic breast cancer could be used to enhance breast cancer risk-stratification, and allow implementation of targeted screening and preventive strategies that would ultimately improve breast cancer prognosis.

scholarly journals Epigenome-wide DNA methylation and risk of breast cancer: a systematic review

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kaoutar Ennour-Idrissi ◽  
Dzevka Dragic ◽  
Francine Durocher ◽  
Caroline Diorio
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Risk Of Bias ◽  
Global Dna Methylation ◽  
Dna Hypomethylation ◽  
Epigenetic Age ◽  
Potential Biomarker

Abstract Background DNA methylation is a potential biomarker for early detection of breast cancer. However, robust evidence of a prospective relationship between DNA methylation patterns and breast cancer risk is still lacking. The objective of this study is to provide a systematic analysis of the findings of epigenome-wide DNA methylation studies on breast cancer risk, in light of their methodological strengths and weaknesses. Methods We searched major databases (MEDLINE, EMBASE, Web of Science, CENTRAL) from inception up to 30th June 2019, for observational or intervention studies investigating the association between epigenome-wide DNA methylation (using the HM450k or EPIC BeadChip), measured in any type of human sample, and breast cancer risk. A pre-established protocol was drawn up following the Cochrane Reviews rigorous methodology. Study selection, data abstraction, and risk of bias assessment were performed by at least two investigators. A qualitative synthesis and systematic comparison of the strengths and weaknesses of studies was performed. Results Overall, 20 studies using the HM450k BeadChip were included, 17 of which had measured blood-derived DNA methylation. There was a consistent trend toward an association of global blood-derived DNA hypomethylation and higher epigenetic age with higher risk of breast cancer. The strength of associations was modest for global hypomethylation and relatively weak for most of epigenetic age algorithms. Differences in length of follow-up periods may have influenced the ability to detect associations, as studies reporting follow-up periods shorter than 10 years were more likely to observe an association with global DNA methylation. Probe-wise differential methylation analyses identified between one and 806 differentially methylated CpGs positions in 10 studies. None of the identified differentially methylated sites overlapped between studies. Three studies used breast tissue DNA and suffered major methodological issues that precludes any conclusion. Overall risk of bias was critical mainly because of incomplete control of confounding. Important issues relative to data preprocessing could have limited the consistency of results. Conclusions Global DNA methylation may be a short-term predictor of breast cancer risk. Further studies with rigorous methodology are needed to determine spatial distribution of DNA hypomethylation and identify differentially methylated sites associated with risk of breast cancer. Prospero registration number CRD42020147244

scholarly journals Estrogen Receptor Expression in Benign Breast Epithelium and Breast Cancer Risk

1998 ◽  
Vol 90 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Seema A. Khan ◽  
Mary A. M. Rogers ◽  
Kamal K. Khurana ◽  
Michael M. Meguid ◽  
Patricia J. Numann
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Breast Epithelium

scholarly journals Dissecting the Biology of Menstrual Cycle-Associated Breast Cancer Risk

2016 ◽  
Vol 6 ◽  
Author(s):  
Vahid Atashgaran ◽  
Joseph Wrin ◽  
Simon Charles Barry ◽  
Pallave Dasari ◽  
Wendy V. Ingman
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Breast Cancer Risk ◽  
Cancer Risk

scholarly journals Loss of Heterozygosity in Benign Breast Epithelium in Relation to Breast Cancer Risk

2002 ◽  
Vol 94 (11) ◽  
pp. 858-860 ◽  
Author(s):  
D. M. Euhus ◽  
L. Cler ◽  
N. Shivapurkar ◽  
S. Milchgrub ◽  
G. N. Peters ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Loss Of Heterozygosity ◽  
Breast Epithelium

scholarly journals Exercise lowers estrogen and progesterone levels in premenopausal women at high risk of breast cancer

2011 ◽  
Vol 111 (6) ◽  
pp. 1687-1693 ◽  
Author(s):  
D. A. Kossman ◽  
N. I. Williams ◽  
S. M. Domchek ◽  
M. S. Kurzer ◽  
J. E. Stopfer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Menstrual Cycle ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Luteal Phase ◽  
Premenopausal Women ◽  
High Risk Women ◽  
Estrogen Exposure ◽  
Hormone Exposure

Experimental and clinical data support a role for estrogens in the development and growth of breast cancer, and lowered estrogen exposure reduces breast cancer recurrence and new diagnoses in high-risk women. There is varied evidence that increased physical activity is associated with breast cancer risk reduction in both pre- and postmenopausal women, perhaps via lowered estrogen levels. The purpose of this study was to assess whether exercise intervention in premenopausal women at increased breast cancer risk reduces estrogen or progesterone levels. Seven healthy premenopausal women at high risk for breast cancer completed a seven-menstrual-cycle study. The study began with two preintervention cycles of baseline measurement of hormone levels via daily first-morning urine collection, allowing calculation of average area under the curve (AUC) hormone exposure across the menstrual cycle. Participants then began five cycles of exercise training to a maintenance level of 300 min per week at 80–85% of maximal aerobic capacity. During the last two exercise cycles, urinary estradiol and progesterone levels were again measured daily. Total estrogen exposure declined by 18.9% and total progesterone exposure by 23.7%. The declines were mostly due to decreased luteal phase levels, although menstrual cycle and luteal phase lengths were unchanged. The study demonstrated the feasibility of daily urine samples and AUC measurement to assess hormone exposure in experimental studies of the impact of interventions on ovarian hormones. The results suggest value in exercise interventions to reduce hormone levels in high-risk women with few side effects and the potential for incremental benefits to surgical or pharmacologic interventions.

scholarly journals Menstrual Cycle Characteristics and History of Ovulatory Infertility in Relation to Breast Cancer Risk in a Large Cohort of US Women

1998 ◽  
Vol 147 (7) ◽  
pp. 636-643 ◽  
Author(s):  
M. Garland ◽  
D. J. Hunter ◽  
G. A. Colditz ◽  
J. E. Manson ◽  
M. J. Stampfer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Large Cohort ◽  
History Of ◽  
Ovulatory Infertility
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