Immunoblotting Analysis of Intracellular PD-L1 Levels in Interferon-γ-Treated Ovarian Cancer Cells Stably Transfected with Bcl3 shRNA

2020 ◽  
pp. 211-220 ◽  
Author(s):  
Sveta Padmanabhan ◽  
Yue Zou ◽  
Ivana Vancurova
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Interferon Γ ◽  
Ovarian Cancer Cells ◽  
Immunoblotting Analysis

Interferon‐γ Induces PD‐L1 Expression in Ovarian Cancer Cells by JAK/STAT1 Signaling

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Sveta Padmanabhan ◽  
Bijaya Gaire ◽  
Daniel de Leon ◽  
Ales Vancura ◽  
Ivana Vancurova
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Interferon Γ ◽  
Ovarian Cancer Cells ◽  
Stat1 Signaling

Cytotoxic effects of disulfiram and synergism with cisplatin on ovarian cancer cells in vitro

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Cytotoxic Effects

Lupeol Inhibits Proliferation and Promotes Apoptosis of Ovarian Cancer Cells by Inactivating Phosphoinositide-3-Kinase/Protein Kinase B/ Mammalian Target of Rapamycin Pathway

2020 ◽  
Vol 19 (2) ◽  
pp. 206-210
Author(s):  
Feng Chen ◽  
Bei Zhang
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Protein Kinase ◽  
Cell Viability ◽  
Cancer Cells ◽  
Protein Kinase B ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Ovarian Cancer Cells ◽  
Phosphoinositide 3 Kinase

Lupeol exhibits multiple pharmacological activities including, anticancerous, anti-inflammatory, and antioxidant. The aim of this study was to explore the anticancerous activity of lupeol on ovarian cancer cells and examine its mechanism of action. To this end, increasing concentrations of lupeol on cell viability, cell cycle, and apoptosis in Caov-3 cells were evaluated. Lupeol inhibited cell viability, induced G1 phase arrest in cell cycle, increased cell apoptosis, and inhibited the ratio of phospho-Akt/protein kinase B and phospho-mammalian target of rapamycin/mammalian target of rapamycin. In conclusion, these data suggest that lupeol may play a therapeutic role in ovarian cancer.

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