Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population

2007 ◽  
Keyword(s):  
Oldest Old ◽  
Human Longevity ◽  
Individual Life ◽  
Life Duration

scholarly journals Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Yeo Jin Kim ◽  
Hyun Soo Kim ◽  
Young Rok Seo
Keyword(s):  
Dna Repair ◽  
Biological Networks ◽  
Genetic Variants ◽  
Healthy Aging ◽  
Oldest Old ◽  
Genomic Research ◽  
Human Longevity ◽  
Genomic Databases ◽  
Aged Population ◽  
Genomic Study

Aged population is increasing worldwide due to the aging process that is inevitable. Accordingly, longevity and healthy aging have been spotlighted to promote social contribution of aged population. Many studies in the past few decades have reported the process of aging and longevity, emphasizing the importance of maintaining genomic stability in exceptionally long-lived population. Underlying reason of longevity remains unclear due to its complexity involving multiple factors. With advances in sequencing technology and human genome-associated approaches, studies based on population-based genomic studies are increasing. In this review, we summarize recent longevity and healthy aging studies of human population focusing on DNA repair as a major factor in maintaining genome integrity. To keep pace with recent growth in genomic research, aging- and longevity-associated genomic databases are also briefly introduced. To suggest novel approaches to investigate longevity-associated genetic variants related to DNA repair using genomic databases, gene set analysis was conducted, focusing on DNA repair- and longevity-associated genes. Their biological networks were additionally analyzed to grasp major factors containing genetic variants of human longevity and healthy aging in DNA repair mechanisms. In summary, this review emphasizes DNA repair activity in human longevity and suggests approach to conduct DNA repair-associated genomic study on human healthy aging.

What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians

2002 ◽  
Vol 37 (10-11) ◽  
pp. 1263-1271 ◽  
Author(s):  
Massimiliano Bonafè ◽  
Cristiana Barbi ◽  
Gianluca Storci ◽  
Stefano Salvioli ◽  
Miriam Capri ◽  
...  
Keyword(s):  
Oldest Old ◽  
Human Longevity

Familial Transmission of Human Longevity Among the Oldest-Old in China

2009 ◽  
Vol 29 (3) ◽  
pp. 308-332 ◽  
Author(s):  
Danzhen You ◽  
Danan Gu ◽  
Zeng Yi
Keyword(s):  
Oldest Old ◽  
Human Longevity ◽  
Familial Transmission

scholarly journals INTERACTIONS BETWEEN GENES FROM AGING-RELATED PATHWAYS: IMPACT ON HUMAN LONGEVITY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S899-S899
Author(s):  
Svetlana Ukraintseva ◽  
Matt Duan ◽  
Deqing Wu ◽  
Konstantin Arbeev ◽  
Alexander Kulminski ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Genetic Heterogeneity ◽  
Significant Interaction ◽  
Oldest Old ◽  
Interaction Effects ◽  
Genetic Interactions ◽  
Human Longevity ◽  
Cell Responses ◽  
Nominal Significance

Abstract Role of genetic interactions (GxG) in human longevity remains poorly understood. We hypothesized that GxG between genes from biologically connected pathways involved in aging may impact longevity. To test this hypothesis, we selected 53 candidate genes from the aging-related pathways (IGF-1/AKT/FOXO3A, TP53/P21/P16, and mTOR/S6K mediated) that are known to jointly influence outcomes of cell responses to stress and damage, such as apoptosis, senescence, growth/proliferation, and autophagy. We evaluated the effects of interactions between SNPs in these genes on longevity in LLFS and CARe data. RESULTS: The IGF1R, PPARGC1A and BCL2 genes were consistently involved in top GxG effects (p<10-6) on survival in the oldest old (85+ and 95+). One SNP, rs2970870 in PPARGC1A gene, was broadly involved in significant interaction effects on survival 96+ (p<10-7) when paired with SNPs in IGF1R and NFKB1 genes. This SNP individually was associated with survival with nominal significance only; therefore, it would have not been selected in a GWAS. We conclude that interactions between genes from aging-related pathways that regulate cell responses and resilience to damage may have major impact on human longevity and contribute to its genetic heterogeneity. The research was supported by the NIA/NIH grants R01AG062623, U19AG063893, P01AG043352.

scholarly journals MIDLIFE FACTORS THAT INFLUENCE THE AGING PROCESS: AN INDIAN PERSPECTIVE

2017 ◽  
pp. 1-6
Author(s):  
S. Puri ◽  
M. Shaheen ◽  
D.H. Pai Panandiker ◽  
R. Sinha
Keyword(s):  
Physical Activity ◽  
Biological Process ◽  
Oldest Old ◽  
Human Longevity ◽  
Activity Levels ◽  
Age Related ◽  
Diet And Physical Activity ◽  
Established Fact ◽  
Refined Carbohydrates ◽  
Indian Perspective

Increasing number of oldest old worldwide has made human longevity a major area of scientific research. It is a well-established fact that the health of an individual and the population in general are the result of interactions between genetics and a number of environmental factors; nutrition and physical activity being of major importance. The Asian Indian phenotype predisposes Indians to NCDs, more so at an earlier age. Indian diets are in a state of transition with increasing amounts of refined carbohydrates and fats being consumed. Physical activity levels are markedly low. Concomitantly, a sharp rise in the prevalence of non-communicable diseases (NCDs) like diabetes, hypertension, cardiovascular diseases and cancers has been observed. Although some of the physiological changes experienced by older adults occur primarily as a result of the biological process of aging, lifestyle factors – such as diet and physical activity – are important modulators of the risk factors associated with chronic disease and even age related decline.

Perceptions of Qualities of Life: Duration Neglect and the Peak-and- End Effect

1999 ◽  
Author(s):  
Derrick Wirtz ◽  
Ed Diener ◽  
Lonnie Brewer ◽  
Shige Oishi
Keyword(s):  
End Effect ◽  
Life Duration ◽  
Duration Neglect

Caregiving in Advanced Years: The Oldest Old As Our Caregivers

2010 ◽  
Author(s):  
Maureen K. Keaveny ◽  
Vitae Felix ◽  
Terrance L. Walker ◽  
David W. Coon
Keyword(s):  
Oldest Old
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